公开(公告)号：US20080221635A1

公开(公告)日：2008-09-11

申请号：US12048144

申请日：2008-03-13

申请人： Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

发明人： Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/365

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

摘要翻译： 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US06937901B2

公开(公告)日：2005-08-30

申请号：US09999255

申请日：2001-10-31

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37 ,  A61N1/18

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

公开(公告)号：US06768924B2

公开(公告)日：2004-07-27

申请号：US10038225

申请日：2002-01-03

申请人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Qingsheng Zhu

发明人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1362

CPC分类号： A61N1/3712 ,  A61N1/3684 ,  A61N1/3714

摘要： An implantable cardiac rhythm/function management device that automatically determines whether or not a pacing stimulus to the ventricles results in capture by detecting propagated depolarizations at stimulating and non-stimulating electrodes. The device of the present invention is suitable for use in either a single or multiple electrode pacing/sensing configuration and may be utilized to verify either atrial or ventricular capture of a heart having either normal or abnormal intrinsic AV conduction.

摘要翻译： 一种植入式心律/功能管理装置，其自动确定对心室的起搏刺激是否通过检测刺激和非刺激电极处的传播去极化而导致捕获。 本发明的装置适用于单电极或多电极起搏/感测配置，并且可用于验证具有正常或异常固有AV传导的心脏的心房或心室捕获。

公开(公告)号：US07970471B2

公开(公告)日：2011-06-28

申请号：US11776699

申请日：2007-07-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/18

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US07245970B2

公开(公告)日：2007-07-17

申请号：US11168099

申请日：2005-06-28

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US08295927B2

公开(公告)日：2012-10-23

申请号：US12254631

申请日：2008-10-20

申请人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US08214026B2

公开(公告)日：2012-07-03

申请号：US12976397

申请日：2010-12-22

申请人： Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

发明人： Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B34/20 ,  A61B2034/2072 ,  A61N1/3627 ,  A61N1/3682

摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.

摘要翻译： 公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。 系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。 电极位置的确定可用于自动调整VRT器件的工作参数。 此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

公开(公告)号：US07440803B2

公开(公告)日：2008-10-21

申请号：US11264941

申请日：2005-11-02

申请人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US06622040B2

公开(公告)日：2003-09-16

申请号：US09738407

申请日：2000-12-15

申请人： Jiang Ding ,  Julio C. Spinelli ,  Yinghong Yu ,  Andrew P. Kramer

发明人： Jiang Ding ,  Julio C. Spinelli ,  Yinghong Yu ,  Andrew P. Kramer

IPC分类号： A61N1362

CPC分类号： A61N1/36592 ,  A61B5/0472 ,  A61N1/3627 ,  A61N1/3684

摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

公开(公告)号：US08103345B2

公开(公告)日：2012-01-24

申请号：US12955218

申请日：2010-11-29

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N1/365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。