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公开(公告)号：US10711299B2
公开(公告)日：2020-07-14
申请号：US15611573
申请日：2017-06-01
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Craig Wenger , Mel Davey , Keith G. Fife , Jimmy Jia , Brian Reed , Brett J. Gyarfas
IPC: C12Q1/6869 , G16B30/00 , G01N21/64
Abstract: System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.
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公开(公告)号：US20220065785A1
公开(公告)日：2022-03-03
申请号：US17381139
申请日：2021-07-20
Applicant: Quantum-Si Incorporated
Inventor： Minh Duc Cao , Mel Davey
Abstract: Techniques for evaluating change points in sequencing data during a sequencing reaction is described. The techniques may include obtaining data regarding light detected over time from luminescent labels associated with at least one molecule undergoing a sequencing reaction, evaluating candidate change points of the data within a time window of the data that varies over time, and outputting information identifying a set of change points based on evaluating the candidate change points. The set of change points may be used to determine pulse segments and individual nucleotides corresponding to at least some of the pulse segments.
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Patent Agency Ranking
公开(公告)号：US20200291467A1
公开(公告)日：2020-09-17
申请号：US16889917
申请日：2020-06-02
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Craig Wenger , Mel Davey , Keith G. Flfe , Jimmy Jia , Brian Reed , Brett J. Gyarfas
IPC: C12Q1/6869 , G16B30/00 , G01N21/64
Abstract: System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.
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4.发明申请公开(公告)号：US20190383737A1
公开(公告)日：2019-12-19
申请号：US16442206
申请日：2019-06-14
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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公开(公告)号：US20170349944A1
公开(公告)日：2017-12-07
申请号：US15611573
申请日：2017-06-01
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Craig Wenger , Mel Davey , Keith G. Fife , Jimmy Jia , Brian Reed , Brett J. Gyarfas
Abstract: System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.
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6.发明公开公开(公告)号：US20240068943A1
公开(公告)日：2024-02-29
申请号：US18500999
申请日：2023-11-02
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Thomas Raymond Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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公开(公告)号：US11808700B2
公开(公告)日：2023-11-07
申请号：US16442206
申请日：2019-06-14
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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