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公开(公告)号：US12123772B2
公开(公告)日：2024-10-22
申请号：US17839698
申请日：2022-06-14
CPC分类号： G01J1/44 , G01N21/6408 , G01N21/6458 , H04N25/77 , G01J2001/446 , G01J2001/448 , G01N21/6428 , G01N2021/6439 , G06T7/0012 , G06T2207/10028 , G06T2207/10064 , G06T2207/30204 , H04N25/76
摘要： An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
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公开(公告)号：US20230375475A1
公开(公告)日：2023-11-23
申请号：US18356150
申请日：2023-07-20
发明人： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC分类号： G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/77 , G01N33/543
CPC分类号： G01N21/6428 , G01N21/648 , C12Q1/6869 , C12Q1/6874 , G01N21/6408 , G01N21/6454 , G01N21/6486 , G01N21/7743 , G01N33/54373 , G01N2021/6421 , G01N2021/6419
摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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公开(公告)号：US20230258862A1
公开(公告)日：2023-08-17
申请号：US18138700
申请日：2023-04-24
发明人： Jonathan M. Rothberg , Ali Kabir , Gerard Schmid , Jason w. Sickler , Paul E. Glenn , Lawrence C. West , Kyle Preston , Alexander Gondarenko , Benjamin Cipriany , James Beach , Keith G. Fife , Farshid Ghasemi
CPC分类号： G02B6/12016 , G01N21/253 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01M11/35 , G02B6/1228 , G02B6/29319 , G02B6/29344 , G02B6/305 , G02B2006/12147 , G02B2006/12195
摘要： System and methods for optical power distribution to a large numbers of sample wells within an integrated device that can analyze single molecules and perform nucleic acid sequencing are described. The integrated device may include a grating coupler configured to receive an optical beam from an optical source and optical splitters configured to divide optical power of the grating coupler to waveguides of the integrated device positioned to couple with the sample wells. Outputs of the grating coupler may vary in one or more dimensions to account for an optical intensity profile of the optical source.
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公开(公告)号：US20220349823A1
公开(公告)日：2022-11-03
申请号：US17862297
申请日：2022-07-11
发明人： Jonathan M. Rothberg , Ali Kabiri , Gerard Schmid , Keith G. Fife , James Beach , Jason W. Sickler , Lawrence C. West , Paul E. Glenn , Kyle Preston , Farshid Ghasemi , Benjamin Cipriany , Jeremy Lackey
IPC分类号： G01N21/64 , C12Q1/6869 , C12Q1/6874 , G01N21/77 , G01N33/543
摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
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5.发明授权公开(公告)号：US11428635B2
公开(公告)日：2022-08-30
申请号：US16028159
申请日：2018-07-05
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
IPC分类号： G01N21/64 , G01N21/77 , C12Q1/6869 , C12Q1/6874 , B01L3/00
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
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6.发明申请公开(公告)号：US20220099575A1
公开(公告)日：2022-03-31
申请号：US17497835
申请日：2021-10-08
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
IPC分类号： G01N21/64 , C12Q1/6874 , C12Q1/6869
摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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公开(公告)号：US11287382B2
公开(公告)日：2022-03-29
申请号：US16689004
申请日：2019-11-19
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC分类号： G01N21/64 , C12Q1/6874 , G01N21/77 , B01L3/00 , C12Q1/6869
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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8.发明授权公开(公告)号：US10288566B2
公开(公告)日：2019-05-14
申请号：US15845996
申请日：2017-12-18
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
IPC分类号： G01N21/64 , C12Q1/6874 , C12Q1/6869
摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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公开(公告)号：US20180173000A1
公开(公告)日：2018-06-21
申请号：US15842720
申请日：2017-12-14
摘要： Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
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10.发明授权公开(公告)号：US09885657B2
公开(公告)日：2018-02-06
申请号：US14821688
申请日：2015-08-07
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
CPC分类号： G01N21/6408 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6454 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6463 , G01N2201/0696 , G01N2201/08 , G01N2201/12
摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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