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公开(公告)号:US11932906B2
公开(公告)日:2024-03-19
申请号:US17350509
申请日:2021-06-17
发明人: Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC分类号: C12Q1/6869 , B01L3/00 , C08L1/02 , C12Q1/6806 , G01N21/64 , G01N27/447 , G01N30/86 , G01N30/88
CPC分类号: C12Q1/6869 , B01L3/502761 , B01L3/50857 , C08L1/02 , C12Q1/6806 , G01N21/6428 , G01N21/6454 , G01N27/44743 , G01N27/44782 , G01N30/86 , B01L2200/0647 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0415 , B01L2400/0421 , G01N27/447 , G01N30/88
摘要: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号:US11719639B2
公开(公告)日:2023-08-08
申请号:US17190331
申请日:2021-03-02
发明人: Gerard Schmid , Dajiang Yang , Eric A. G. Webster , Xin Wang , Todd Rearick , Changhoon Choi , Ali Kabiri , Kyle Preston , Brian Reed
IPC分类号: G01N21/64 , H01L27/146
CPC分类号: G01N21/6454 , G01N21/6408 , G01N21/6428 , H01L27/14603 , G01N2021/6463
摘要: Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information. In some embodiments, the information comprises at least three, four, and/or five members selected from the group comprising wavelength information, luminescence lifetime information, intensity information, pulse duration information, and interpulse duration information. In some embodiments, the information obtained may be used to identify the sample.
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公开(公告)号:US20230221253A1
公开(公告)日:2023-07-13
申请号:US18095767
申请日:2023-01-11
发明人: Brian Reed , Todd Rearick , Gerard Schmid , Haidong Huang
CPC分类号: G01N21/6428 , G01N33/6821 , G01N33/6824 , G01N33/582 , G01N1/28 , G01N2021/6439 , G01N2458/00 , G16B30/00
摘要: Techniques for multi-dimensional signal analysis are described herein. The techniques may be used in one or more sequencing applications. For example, according to some aspects, there is provided a method comprising: determining information about a sample that emits emission light in response to excitation light based on at least one of pulse duration and interpulse duration and at least two of wavelength, intensity, and lifetime of the emission light, wherein the sample comprises a reagent configured to be coupled to a luminescent label, and wherein a shielding element is disposed between the reagent and the luminescent label.
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公开(公告)号:US11299778B2
公开(公告)日:2022-04-12
申请号:US16277113
申请日:2019-02-15
发明人: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC分类号: C12Q1/6869 , G01N21/64 , H01L27/146 , H01S3/101 , H01S3/13 , H01S3/105 , H01S3/081 , H01S3/11 , H01S3/0941 , H01S3/10 , H01S3/00 , H01S3/16 , G01S7/481 , H01S3/04
摘要: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号:US20180175582A1
公开(公告)日:2018-06-21
申请号:US15844469
申请日:2017-12-15
发明人: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
CPC分类号: H01S3/1115 , G02F1/37 , H01S3/0092 , H01S3/042 , H01S3/08072 , H01S3/0941 , H01S3/10046 , H01S3/1611 , H01S3/1673
摘要: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号:US20240353326A1
公开(公告)日:2024-10-24
申请号:US18539068
申请日:2023-12-13
发明人: Gerard Schmid , Dajiang Yang , Eric A.G. Webster , Xin Wang , Todd Rearick , Changhoon Choi , Ali Kabiri , Kyle Preston
IPC分类号: G01N21/64
CPC分类号: G01N21/6428 , G01N2021/6417 , G01N2021/6439
摘要: Some aspects relate to integrated devices for obtaining timing and/or spectral information from incident light. In some embodiments, a pixel may include one or more charge storage regions configured to receive charge carriers generated responsive to incident photons from a light source, with charge carriers stored in the charge storage region(s) indicative of spectral and timing information. In some embodiments, a pixel may include regions having different depths, each configured to generate charge carriers responsive to incident photons. In some embodiments, a pixel may include multiple charge storage regions having different depths, and one or more of the charge storage regions may be configured to receive the incident photons and generate charge carriers therein. In some embodiments, a pixel may include an optical sorting element configured to direct at least some incident photons to one charge storage region and other incident photons to another charge storage region.
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公开(公告)号:US12123772B2
公开(公告)日:2024-10-22
申请号:US17839698
申请日:2022-06-14
CPC分类号: G01J1/44 , G01N21/6408 , G01N21/6458 , H04N25/77 , G01J2001/446 , G01J2001/448 , G01N21/6428 , G01N2021/6439 , G06T7/0012 , G06T2207/10028 , G06T2207/10064 , G06T2207/30204 , H04N25/76
摘要: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
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公开(公告)号:US12092579B2
公开(公告)日:2024-09-17
申请号:US18093213
申请日:2023-01-04
发明人: Eric A. G. Webster , Dajiang Yang , Xin Wang , Zhaoyu He , Changhoon Choi , Peter J. Lim , Todd Rearick
IPC分类号: G01N21/64 , G05F1/46 , H01L27/146
CPC分类号: G01N21/6456 , G01N21/6408 , G01N21/6454 , G05F1/46 , H01L27/14603 , H01L27/14614 , H01L27/14616 , H01L27/14636 , H01L27/14643 , G01N2021/6439
摘要: Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device. In some aspects, multiple pixels of an integrated circuit may be configured to receive a same control signal and conduct charge carriers responsive to the control signal substantially at the same time. In some aspects, an integrated circuit may have modulated charge transfer channel voltage thresholds, such as by having different charge transfer channel lengths, and/or a doped portion configured to set a voltage threshold for charge transfer. In some aspects, an integrated circuit may have a via structure having a plurality of vias extending between continuous portions of at least two metal layers. In some aspects, an integrated circuit may include a row of pixels and a voltage source configured to provide a voltage to bias a semiconductor substrate of the integrated circuit along the row of pixels.
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公开(公告)号:US11869917B2
公开(公告)日:2024-01-09
申请号:US17149574
申请日:2021-01-14
发明人: Eric A. G. Webster , Changhoon Choi , Dajiang Yang , Xin Wang , Todd Rearick , Kyle Preston , Ali Kabiri , Gerard Schmid
IPC分类号: H01L27/146
CPC分类号: H01L27/14643 , H01L27/14683
摘要: Aspects of the technology described herein relate to improved semiconductor-based image sensor designs. In some embodiments, an integrated circuit may comprise a photodetection region and a drain region electrically coupled to the photodetection region, and the photodetection region may be configured to induce an intrinsic electric field in a direction from the photodetection region to the drain region(s). In some embodiments, a charge storage region and the drain region may be positioned on a same side of the photodetection region. In some embodiments, at least one drain layer may be configured to receive incident photons and/or charge carriers via the photodetection region. In some embodiments, an integrated circuit may comprise a plurality of pixels and a control circuit configured to control a transfer of charge carriers in the plurality of pixels.
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公开(公告)号:US11804499B2
公开(公告)日:2023-10-31
申请号:US16913688
申请日:2020-06-26
发明人: Dajiang Yang , Farshid Ghasemi , Keith G. Fife , Todd Rearick , Ali Kabiri , Gerard Schmid , Eric A. G. Webster
IPC分类号: H01L27/146 , H04N25/771
CPC分类号: H01L27/14609 , H01L27/14623 , H01L27/14625 , H01L27/14636 , H04N25/771
摘要: Described herein are techniques to reduce or remove the impact of secondary path photons and/or charge carriers on storage bins of an integrated device to improve noise performance, and thus, sample analysis. Some embodiments relate to optical rejection techniques such as including an optical barrier positioned to block at least some photons from reaching the storage bins. Some embodiments relate to electrical rejection techniques such as including an electrical barrier configured to block at least some charge carriers from reaching the storage bins along at least one secondary path. Some embodiments relate to an integrated device in which at least one storage bin is shaped and/or positioned relative to the photodetector to facilitate receipt of some charge carriers (e.g., fluorescent emission charge carriers) and/or photons and to impede receipt of other charge carriers (e.g., noise charge carriers) and/or photons.
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