公开(公告)号：US20040002440A1

公开(公告)日：2004-01-01

申请号：US10369435

申请日：2003-02-19

Applicant: Queensland University of Technology

Inventor： Peter Timms ,  Sarah Anne Mathews

IPC: A61K038/16 ,  A61K048/00 ,  G01N033/554 ,  G01N033/569 ,  C12Q001/68

CPC classification number: C07K14/295 ,  A61K39/00 ,  G01N33/56927

Abstract: The present invention discloses compositions and methods for detecting organisms of the Chlamydiaceae family, including species of Chlamydia and Chlamyclophila, in the persistent phase of their developmental cycle and for the diagnosis of chronic or persistent infections caused by such organisms. The present invention also discloses methods for screening agents that are useful inter alia for modulating a gene whose expression is altered in the persistent phase of the chiamydial developmental cycle or for modulating the level and/or functional activity of an expression product of that gene. Also disclosed are methods and compositions for the treatment and/or prophylaxis of infections, including chronic infections, caused by chamydial organisms using the aforesaid modulatory agents and optionally agents that are effective in modulating the expression of a gene associated with the lytic phase of said developmental cycle or in modulating the level and/or functional activity of an expression product of that gene. The invention also discloses methods and compositions for the treatment and/or prophylaxis of such infections using a first immunopotentiating agent that elicits the production of elements that are immuno-interactive with an antigen associated with the persistent phase of the chlamydial developmental cycle and a second immunopotentiating agent that elicits the production of elements that are immuno-interactive with an antigen associated with the lytic phase of said developmental cycle.

Abstract translation: 本发明公开了用于检测衣原体科（Chlamydiaceae）家族的生物体的组合物和方法，包括衣原体和沙眼衣原体的种类，其发育周期的持续期以及用于诊断由这些生物引起的慢性或持续性感染。 本发明还公开了用于筛选试剂的方法，所述筛选试剂特别用于调节其在chiamydial发育周期的持续期中表达改变的基因或用于调节该基因的表达产物的水平和/或功能活性。 还公开了用于使用上述调节剂和任选的有效调节与所述发育的溶解期相关基因表达的治疗和/或预防感染的方法和组合物，包括慢性感染 循环或调节该基因的表达产物的水平和/或功能活性。 本发明还公开了使用第一免疫增强剂治疗和/或预防这种感染的方法和组合物，所述第一免疫增强剂引发与与衣原体发育周期的持续期相关的抗原免疫相互作用的元件，以及第二免疫增强剂 引发与与所述发育周期的溶解期相关的抗原免疫相互作用的元件的产生。