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    Novel probes for the detection of mycobacteria
    1.
    发明申请
    Novel probes for the detection of mycobacteria 审中-公开
    用于检测分枝杆菌的新型探针

    公开(公告)号：US20040265934A1

    公开(公告)日：2004-12-30

    申请号：US10786076

    申请日：2004-02-26

    申请人： Dako A/S

    发明人： Henrik Stender ,  Kaare Lund ,  Tina Anderson Mollerup

    IPC分类号： C12Q001/68 ,  G01N033/554 ,  G01N033/569

    CPC分类号： C07K14/003 ,  C12Q1/689

    摘要： Novel hybridisation assay probes and mixtures of such probes for detecting a target sequence of one or mycobacteria optionally present in a sample. The probes may suitable be directed to target sequences of mycobacterial rDNA, precursor rRNA, or rRNA, said probes being capable of forming detectable hybrids. The probes are in particular directed to mycobacterial rDNA, to precursor rRNA, or to 23S, 16S or 5S rRNA The probes are useful for detecting the organisms in test samples such as sputum, laryngeal swabs, gastric lavage, bronchial washings, biopsies, aspirates, expectorates, body fluids (spinal, pleural, pericardial, synovial, blood, pus, bone marrow), urine, tissue sections as well as food samples, soil, air and water samples, and cultures thereof.

    摘要翻译： 新型杂交测定探针和这种探针的混合物，用于检测任选存在于样品中的一种或分枝杆菌的靶序列。 探针可以适用于分枝杆菌rDNA，前体rRNA或rRNA的靶序列，所述探针能够形成可检测的杂交体。 探针特别针对分枝杆菌rDNA，前体rRNA或23S，16S或5S rRNA。探针可用于检测测试样品中的生物体，如痰液，喉拭子，胃灌洗液，支气管洗涤液，活检组织，抽吸液， 痰液，体液（脊髓，胸膜，心包，滑液，血液，脓液，骨髓），尿液，组织切片以及食物样品，土壤，空气和水样品及其培养物。

    Methods for detecting presence of cellular constituents
    2.
    发明申请
    Methods for detecting presence of cellular constituents 审中-公开
    检测细胞成分存在的方法

    公开(公告)号：US20040265877A1

    公开(公告)日：2004-12-30

    申请号：US10833490

    申请日：2004-04-28

    申请人： Marantech Holding, LLC

    发明人： Marvin S. Antelman ,  Perry W. Antelman

    IPC分类号： C12Q001/68 ,  G01N033/53 ,  G01N033/567 ,  G01N033/554 ,  G01N033/569

    CPC分类号： G01N33/56911 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/689 ,  G01N33/5091 ,  G01N33/567 ,  G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/57484

    摘要： The invention is directed to methods for detecting, monitoring and/or diagnosing aberrant cellular proliferation, and disorders associated therewith, such as cancer, and/or infection by microorganisms. The detection, monitoring and/or diagnosis comprises contacting a compound of the invention with a cell or fluid sample. Compound binding confirms the presence of an abnormal cell or a protein associated with an abnormal cell or infection by one or more microorganisms, and/or disorders associated with infection by one or more microorganisms.

    摘要翻译： 本发明涉及用于检测，监测和/或诊断异常细胞增殖以及与其相关的疾病如癌症和/或微生物感染的方法。 检测，监测和/或诊断包括将本发明的化合物与细胞或液体样品接触。 化合物结合证实存在与一种或多种微生物异常细胞或感染相关的异常细胞或蛋白质，和/或与一种或多种微生物感染相关的病症。

    Solid composition cantaining bacillus-type non-pathogenic bacterial spores
    3.
    发明申请
    Solid composition cantaining bacillus-type non-pathogenic bacterial spores 有权
    固体组合物可以产生杆菌型非病原菌孢子

    公开(公告)号：US20040241772A1

    公开(公告)日：2004-12-02

    申请号：US10484937

    申请日：2004-07-26

    发明人： Tiziano Prato

    IPC分类号： G01N033/554 ,  G01N033/569 ,  C12N001/20

    CPC分类号： A61K35/742 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/4866

    摘要： The invention relates to a composition of spores of nonpathogenic bacteria of the Bacillus genus, adsorbed onto a matrix made up of at least one water-insoluble adsorbent compound and a cellulose derivative, which can be obtained by the fluidized air bed technique, useful in the pharmaceutical, veterinary and nutrition fields.

    摘要翻译： 本发明涉及一种吸附在由至少一种水不溶性吸附剂化合物和纤维素衍生物构成的基质上的芽孢杆菌属非致病菌的孢子组合物，其可以通过流化床技术获得，可用于 制药，兽医和营养领域。

    Label-free evanescent-field detection of biological and chemical agents
    5.
    发明申请
    Label-free evanescent-field detection of biological and chemical agents 失效
    无标记的生物和化学试剂的渐逝场检测

    公开(公告)号：US20040191765A1

    公开(公告)日：2004-09-30

    申请号：US10794937

    申请日：2004-03-05

    发明人： Eric J. Mozdy ,  Frederic J-Y Quan ,  Po Ki Yuen

    IPC分类号： C12Q001/70 ,  G01N033/554 ,  G01N033/569 ,  C12M001/34

    CPC分类号： G01N33/54373 ,  Y10S435/808 ,  Y10S436/805

    摘要： An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate surface with at least a partial bio- or chemo-responsive layer, which forms a part of a serially renewable sensing region; 2) an optical interrogation apparatus for monitoring the bio- or chemo-responsive layer; and 3) an air-fluid delivery system. The optical interrogation apparatus has a light source, an optical delivery system, and a detection instrument or device. The air-fluid delivery system includes either macro or micro-fluidic passages designed to convey biological or chemical analytes to a sensing region.

    摘要翻译： 提供了一种消逝场传感器系统和使用该系统来检测液体或空气传播的生物病原体，化学试剂和其他有害或有毒物质的方法。 传感器系统包括1）具有至少部分生物或化学响应层的衬底表面的消逝场传感器，其形成串联可再生感测区域的一部分; 2）用于监测生物或化学响应层的光学询问装置; 和3）空气流体输送系统。 光学询问装置具有光源，光学传送系统和检测仪器或装置。 空气流体输送系统包括设计成将生物或化学分析物传送到感测区域的宏观流路或微流体通道。

    Anti-bacterial methods and materials
    6.
    发明申请
    Anti-bacterial methods and materials 审中-公开
    抗菌方法和材料

    公开(公告)号：US20040185496A1

    公开(公告)日：2004-09-23

    申请号：US10818509

    申请日：2004-04-05

    发明人： David W. Holden ,  Ji Min Mei

    IPC分类号： C12Q001/68 ,  G01N033/554 ,  G01N033/569

    CPC分类号： C07K14/31

    摘要： Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel S. aureus mutants useful in vaccines.

    摘要翻译： 识别金黄色葡萄球菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供用于疫苗的新型金黄色葡萄球菌突变体。

    Method of monitoring membrane separation processes
    7.
    发明申请
    Method of monitoring membrane separation processes 审中-公开
    监测膜分离过程的方法

    公开(公告)号：US20040185472A1

    公开(公告)日：2004-09-23

    申请号：US10737475

    申请日：2003-12-16

    发明人： E. H. Kelle Zeiher ,  Bosco P. Ho ,  John E. Hoots ,  Binaifer S. Bedford ,  Martin R. Godfrey

    IPC分类号： C12Q001/68 ,  G01N033/554 ,  G01N033/569

    CPC分类号： B01D65/102 ,  B01D61/12 ,  B01D61/22 ,  B01D61/54 ,  C02F1/441

    摘要： Methods and systems for monitoring and controlling membrane separation systems are provided. The present invention uses measurable amounts of one or more inert fluorescent tracers added to a feed stream to evaluate and/or control the unit operation of processing such feed stream during membrane separation. The methods and systems of the present invention can be used in a variety of different industrial applications including raw water processing and waste water processing.

    摘要翻译： 提供了用于监测和控制膜分离系统的方法和系统。 本发明使用可测量的一种或多种添加到进料流中的惰性荧光示踪剂来评价和/或控制在膜分离期间处理这种进料流的单元操作。 本发明的方法和系统可用于各种不同的工业应用，包括原水处理和废水处理。

    Bacteriotoxin adsorbents and method of screening the same
    9.
    发明申请
    Bacteriotoxin adsorbents and method of screening the same 审中-公开
    细菌毒素吸附剂和筛选方法相同

    公开(公告)号：US20040137543A1

    公开(公告)日：2004-07-15

    申请号：US10475133

    申请日：2003-10-17

    发明人： Koichi Fukase ,  Hans Peter Nestler

    IPC分类号： C12Q001/68 ,  G01N033/554 ,  G01N033/569

    CPC分类号： C40B30/04 ,  C07K1/047 ,  G01N33/534 ,  G01N33/56911 ,  G01N33/68 ,  G01N33/6845 ,  G01N33/92

    摘要： It is intended to provide novel lipopolysaccharide adsorbents (bacteriotoxin adsorbents) which can be easily synthesized and modified into various analogous structures and are usable in adsorbing various lipopolysaccharides and a method of screening the same. A method of screening a bacteriotoxin adsorbent characterized by performing a binding assay with a peptide library with the use of a lipid A radioisotope-labeled preparation wherein a radioisotope has been introduced into a phosphonoxyethyl derivative of biosynthetic precursor type lipid A or Escherichia coli type lipid A; and bacteriotoxin adsorbents comprising a specific peptide library which are found out by the above screening method.

    摘要翻译： 旨在提供新颖的脂多糖吸附剂（细菌毒素吸附剂），其可以容易地合成和改性成各种类似结构，并且可用于吸附各种脂多糖及其筛选方法。 一种筛选细菌毒素吸附剂的方法，其特征在于使用脂质A放射性同位素标记的制剂进行与肽文库的结合测定，其中将放射性同位素引入生物合成前体型脂质A或大肠杆菌型脂质A的膦氧基乙基衍生物 ; 和包含通过上述筛选方法发现的特异性肽文库的细菌毒素吸附剂。