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公开(公告)号：US07517662B2
公开(公告)日：2009-04-14
申请号：US10633484
申请日：2003-07-31
申请人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
IPC分类号： G01N33/574
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译： 本发明提供了通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改进医学相关条件诊断的方法。 本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的 溶解试样的相关诊断。 根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较 和/或组合疾病和归一化标记的数据，以及评估医学上相关的病症的诊断。
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公开(公告)号：US20090181406A1
公开(公告)日：2009-07-16
申请号：US12400629
申请日：2009-03-09
申请人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译： 本发明提供用于通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改善医学相关条件的诊断的方法和试剂盒。 本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的 溶解试样的相关诊断。 根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较 和/或组合疾病和归一化标记的数据，以及评估医学相关病症的诊断。
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公开(公告)号：US20050272038A1
公开(公告)日：2005-12-08
申请号：US10522912
申请日：2003-07-17
CPC分类号： A61K38/1709 , A61K38/08 , A61K39/00 , C07K14/4703 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of cervical lesions based on detection of gene products encoded by the INK4a gene locus. According to the present invention an improvement in diagnosis may be achieved by assessing the presence or absence or the level of overexpression of at least two different gene products encoded by the INK4a gene locus. In another aspect the present invention relates to peptides derived from cell cycle regulatory proteins, the expression of which is altered in association with tumors in individuals. These peptides according to the present invention may be used for detection and therapy of tumors. For detection purposes the peptides may for example be used to detect antibodies directed against said peptides. In therapeutic respect the peptides may be used for immunotherapy or vaccination approaches. In therapeutic and diagnostic respect the peptides may be used in combination with one or more peptides derived from tumor associated proteins.
摘要翻译： 本发明涉及一种基于由INK4a基因座编码的基因产物的检测来改善子宫颈病变诊断的方法。 根据本发明，可以通过评估由INK4a基因座编码的至少两种不同基因产物的过表达的存在或不存在或水平来实现诊断的改善。 在另一方面，本发明涉及衍生自细胞周期调节蛋白的肽，其表达与个体中的肿瘤相关联地改变。 根据本发明的这些肽可以用于肿瘤的检测和治疗。 为了检测目的，肽可以例如用于检测针对所述肽的抗体。 在治疗方面，肽可以用于免疫治疗或疫苗接种方法。 在治疗和诊断方面，肽可以与一种或多种衍生自肿瘤相关蛋白的肽组合使用。
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公开(公告)号：US20090176204A1
公开(公告)日：2009-07-09
申请号：US12381098
申请日：2009-03-06
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译： 本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标志物来改善发育不良诊断的方法。 特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。 增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。 因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。
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公开(公告)号：US08367353B2
公开(公告)日：2013-02-05
申请号：US12381098
申请日：2009-03-06
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译： 本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标志物来改善发育不良诊断的方法。 特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。 增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。 因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。
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公开(公告)号：US08975036B2
公开(公告)日：2015-03-10
申请号：US12289487
申请日：2008-10-29
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译： 本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标志物来改善发育不良诊断的方法。 特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。 增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。 因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。
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公开(公告)号：US20090068675A1
公开(公告)日：2009-03-12
申请号：US12289487
申请日：2008-10-29
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译： 本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标志物来改善发育不良诊断的方法。 特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。 增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。 因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。
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公开(公告)号：US20070128599A1
公开(公告)日：2007-06-07
申请号：US10533384
申请日：2003-10-21
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/574 , G01N33/57411 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
摘要翻译： 本发明涉及一种基于同时检测INK4a基因产物和至少一种细胞增殖标志物来改善发育不良诊断的方法。 特别地，本发明提供了一种鉴别过表达INK4a基因产物的细胞过度表达INK4a基因产物的发育不良细胞的方法，通过检测适合于表征各细胞的增殖性质的标记物而不发育不良。 增殖特性的表征可以包括检测特征于活性细胞增殖的标志物或一组标志物和/或用于延迟或停止的细胞增殖的特征性标志物或一组标志物。 因此，本文提出的方法能够对组织学和细胞学标本中的发育不良进行特异性诊断。
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