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公开(公告)号：US07517662B2
公开(公告)日：2009-04-14
申请号：US10633484
申请日：2003-07-31
申请人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
IPC分类号： G01N33/574
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译： 本发明提供了通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改进医学相关条件诊断的方法。 本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的 溶解试样的相关诊断。 根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较 和/或组合疾病和归一化标记的数据，以及评估医学上相关的病症的诊断。
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公开(公告)号：US20090181406A1
公开(公告)日：2009-07-16
申请号：US12400629
申请日：2009-03-09
申请人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译： 本发明提供用于通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改善医学相关条件的诊断的方法和试剂盒。 本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的 溶解试样的相关诊断。 根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较 和/或组合疾病和归一化标记的数据，以及评估医学相关病症的诊断。
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公开(公告)号：US07306926B2
公开(公告)日：2007-12-11
申请号：US10650057
申请日：2003-08-26
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N33/57407 , G01N33/57411 , G01N33/57488 , G01N2333/4739
摘要： The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a solubilized body sample. The present invention is particularly directed to a method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or cervical carcinomas in-situ from a solubilized cervical body sample of a human subject, by solubilizing the cervical body sample in a lysis buffer, and determining the overexpression of cyclin dependent kinase inhibitor p16 in the solubilized cervical sample. The invention also concerns a test kit usable for this purpose as well as an in-vitro diagnostic device.
摘要翻译： 本发明涉及一种早期诊断癌症的方法及其初步阶段，其包括确定溶解体样品中细胞周期调节蛋白的过表达。 本发明特别涉及通过将宫颈样品溶解在裂解缓冲液中，从人体受体的溶解的宫颈体样本中原位检测子宫颈癌，子宫颈上皮内瘤变或子宫颈癌的方法，并且确定过表达 的细胞周期蛋白依赖性激酶抑制剂p16在溶解的子宫颈样品中。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。
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4.发明授权公开(公告)号：US07932047B2
公开(公告)日：2011-04-26
申请号：US10569758
申请日：2004-08-20
申请人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
发明人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
IPC分类号： C12Q1/00 , G01N1/00 , G01N21/00 , G01N21/75 , G01N21/76 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574 , C12P21/08
CPC分类号： G01N33/57484 , G01N33/57411 , Y10T436/25
摘要： The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the urinary system, the reproductive tract, cancer associated with HPV infection or cancer of the anogenital tract, from solubilized body samples. The invention is also directed to test kits usable for this purpose as well as in-vitro diagnostic devices. The development of the kits and in-vitro diagnostic devices for the above purpose is also one aspect of the present invention.
摘要翻译： 本发明涉及一种用于早期诊断肿瘤性疾病如癌症及其前体阶段的方法，特别是呼吸道癌症，泌尿系统，生殖道，与HPV感染有关的癌症或肛门生殖道癌症 ，来自溶解的身体样品。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。 用于上述目的的试剂盒和体外诊断装置的开发也是本发明的一个方面。
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5.发明申请公开(公告)号：US20070190529A1
公开(公告)日：2007-08-16
申请号：US10569758
申请日：2004-08-20
申请人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
发明人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/57411 , Y10T436/25
摘要： The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the urinary system, the reproductive tract, cancer associated with HPV infection or cancer of the anogenital tract, from solubilized body samples. The invention is also directed to test kits usable for this purpose as well as in-vitro diagnostic devices. The development of the kits and in-vitro diagnostic devices for the above purpose is also one aspect of the present invention.
摘要翻译： 本发明涉及一种用于早期诊断肿瘤性疾病如癌症及其前体阶段的方法，特别是呼吸道癌症，泌尿系统，生殖道，与HPV感染有关的癌症或肛门生殖道癌症 ，来自溶解的身体样品。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。 用于上述目的的试剂盒和体外诊断装置的开发也是本发明的一个方面。
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公开(公告)号：US20050272038A1
公开(公告)日：2005-12-08
申请号：US10522912
申请日：2003-07-17
CPC分类号： A61K38/1709 , A61K38/08 , A61K39/00 , C07K14/4703 , G01N33/57484
摘要： The present invention relates to a method for improved diagnosis of cervical lesions based on detection of gene products encoded by the INK4a gene locus. According to the present invention an improvement in diagnosis may be achieved by assessing the presence or absence or the level of overexpression of at least two different gene products encoded by the INK4a gene locus. In another aspect the present invention relates to peptides derived from cell cycle regulatory proteins, the expression of which is altered in association with tumors in individuals. These peptides according to the present invention may be used for detection and therapy of tumors. For detection purposes the peptides may for example be used to detect antibodies directed against said peptides. In therapeutic respect the peptides may be used for immunotherapy or vaccination approaches. In therapeutic and diagnostic respect the peptides may be used in combination with one or more peptides derived from tumor associated proteins.
摘要翻译： 本发明涉及一种基于由INK4a基因座编码的基因产物的检测来改善子宫颈病变诊断的方法。 根据本发明，可以通过评估由INK4a基因座编码的至少两种不同基因产物的过表达的存在或不存在或水平来实现诊断的改善。 在另一方面，本发明涉及衍生自细胞周期调节蛋白的肽，其表达与个体中的肿瘤相关联地改变。 根据本发明的这些肽可以用于肿瘤的检测和治疗。 为了检测目的，肽可以例如用于检测针对所述肽的抗体。 在治疗方面，肽可以用于免疫治疗或疫苗接种方法。 在治疗和诊断方面，肽可以与一种或多种衍生自肿瘤相关蛋白的肽组合使用。
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7.发明申请公开(公告)号：US20060216771A1
公开(公告)日：2006-09-28
申请号：US11445888
申请日：2006-06-01
IPC分类号： G01N33/53
CPC分类号： G01N33/57423 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N33/57407 , G01N33/57411 , G01N33/57488 , G01N2333/4739
摘要： The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a solubilized body sample. The present invention is particularly directed to a method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or cervical carcinomas in-situ from a solubilized cervical body sample of a human subject, by solubilizing the cervical body sample in a lysis buffer, and determining the overexpression of cyclin dependent kinase inhibitor p16 in the solubilized cervical sample. The invention also concerns a test kit usable for this purpose as well as an in-vitro diagnostic device.
摘要翻译： 本发明涉及一种早期诊断癌症的方法及其初步阶段，其包括确定溶解体样品中细胞周期调节蛋白的过表达。 本发明特别涉及通过将宫颈样品溶解在裂解缓冲液中，从人体受体的溶解的宫颈体样本中原位检测子宫颈癌，子宫颈上皮内瘤变或子宫颈癌的方法，并且确定过表达 的细胞周期蛋白依赖性激酶抑制剂p16在溶解的子宫颈样品中。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。
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公开(公告)号：US07745145B2
公开(公告)日：2010-06-29
申请号：US11701522
申请日：2007-01-31
申请人： Jacky Schmitt , Matthias Herkert , Michael Oed
发明人： Jacky Schmitt , Matthias Herkert , Michael Oed
IPC分类号： G01N33/53
CPC分类号： G01N1/30
摘要： The present invention relates to a method for stabilization of analytes in solutions of solubilized body samples. The method comprises the steps of solubilizing the body samples obtained from a subject in a suitable sample medium and stabilizing said body sample contained within the sample medium by heating said sample medium for a certain period of time. A further aspect of the invention is a method of a denaturing immunoassay of proteins in solution. The method comprises the steps of bringing a sample containing proteins into contact with a denaturing agent and heating said sample in the presence of the denaturing agent to allow the protein to be denatured.
摘要翻译： 本发明涉及在溶解的身体样品溶液中稳定分析物的方法。 该方法包括以下步骤：将从受试者获得的身体样品溶解在合适的样品介质中，并通过加热所述样品介质一定时间来稳定包含在样品介质中的所述身体样品。 本发明的另一方面是在溶液中蛋白质的变性免疫测定的方法。 该方法包括使含有蛋白质的样品与变性剂接触并在变性剂存在下加热所述样品以使蛋白质变性的步骤。
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公开(公告)号：US20100167323A1
公开(公告)日：2010-07-01
申请号：US12710997
申请日：2010-02-23
申请人： Jacky Schmitt , Matthias Herkert , Michael Oed
发明人： Jacky Schmitt , Matthias Herkert , Michael Oed
IPC分类号： G01N33/53
CPC分类号： G01N1/30
摘要： The present invention relates to a method for stabilization of analytes in solutions of solubilized body samples. The method comprises the steps of solubilizing the body samples obtained from a subject in a suitable sample medium and stabilizing said body sample contained within the sample medium by heating said sample medium for a certain period of time. A further aspect of the invention is a method of a denaturing immunoassay of proteins in solution. The method comprises the steps of bringing a sample containing proteins into contact with a denaturing agent and heating said sample in the presence of the denaturing agent to allow the protein to be denatured.
摘要翻译： 本发明涉及在溶解的身体样品溶液中稳定分析物的方法。 该方法包括以下步骤：将从受试者获得的身体样品溶解在合适的样品介质中，并通过加热所述样品介质一定时间来稳定包含在样品介质中的所述身体样品。 本发明的另一方面是在溶液中蛋白质的变性免疫测定的方法。 该方法包括使含有蛋白质的样品与变性剂接触并在变性剂存在下加热所述样品以使蛋白质变性的步骤。
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公开(公告)号：US07927819B2
公开(公告)日：2011-04-19
申请号：US12710997
申请日：2010-02-23
申请人： Jacky Schmitt , Matthias Herkert , Michael Oed
发明人： Jacky Schmitt , Matthias Herkert , Michael Oed
IPC分类号： G01N33/53
CPC分类号： G01N1/30
摘要： The present invention relates to a method for stabilization of analytes in solutions of solubilized body samples. The method comprises the steps of solubilizing the body samples obtained from a subject in a suitable sample medium and stabilizing said body sample contained within the sample medium by heating said sample medium for a certain period of time. A further aspect of the invention is a method of a denaturing immunoassay of proteins in solution. The method comprises the steps of bringing a sample containing proteins into contact with a denaturing agent and heating said sample in the presence of the denaturing agent to allow the protein to be denatured.
摘要翻译： 本发明涉及在溶解的身体样品溶液中稳定分析物的方法。 该方法包括以下步骤：将从受试者获得的身体样品溶解在合适的样品介质中，并通过加热所述样品介质一定时间来稳定包含在样品介质中的所述身体样品。 本发明的另一方面是在溶液中蛋白质的变性免疫测定的方法。 该方法包括使含有蛋白质的样品与变性剂接触并在变性剂存在下加热所述样品以使蛋白质变性的步骤。
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