利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.049 秒)

    METERED GEL DISPENSER
    1.
    发明申请
    METERED GEL DISPENSER 审中-公开
    计量凝胶分配器

    公开(公告)号：US20100217176A1

    公开(公告)日：2010-08-26

    申请号：US12775053

    申请日：2010-05-06

    申请人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Holger Kraus ,  Peter L. Sadowski ,  Paul Greenhalgh ,  Matthew Young ,  Dominic Reber ,  Martin Murphy

    发明人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Holger Kraus ,  Peter L. Sadowski ,  Paul Greenhalgh ,  Matthew Young ,  Dominic Reber ,  Martin Murphy

    IPC分类号： A61M35/00 ,  A61N1/30

    CPC分类号： A45D40/26 ,  A45D34/04 ,  A45D40/04 ,  G01F11/025

    摘要： The invention relates to a dermal flowable-composition dispenser that includes a body for retaining a supply of the composition, an application portion having an application surface, and a conduit connecting the supply chamber with the application surface for facilitating the reproducible delivery of a predetermined dose of the composition to the application surface. The application surface includes a concave application surface and a front side having an upper rim enclosing the application surface and forming a depression that has a volume that is greater than or equal to the volume of the predetermine dose. Also, the application surface is configured and dimensioned such it can receive the patient's skin to allow for removal of the predetermined dose of the composition, and wherein the concave application surface is shaped such that the entire application surface contacts the patient's skin when the application surface is pressed thereagainst.

    摘要翻译： 本发明涉及一种真皮可流动组合物分配器，其包括用于保持组合物供应的本体，具有施用表面的施用部分和将供应室与施用表面连接的导管，以便于可再现地递送预定剂量 的组合物到应用表面。 施加表面包括凹入的施加表面和前侧，其具有封闭施加表面的上边缘并形成具有大于或等于预定剂量的体积的凹陷的凹陷。 此外，施用表面被构造和定尺寸使得其可以接收患者的皮肤以允许去除组合物的预定剂量，并且其中凹形施用表面成形为使得整个施用表面在使用表面接触患者的皮肤时 被压在那里

    Pharmaceutical compositions of nicotine and methods of use thereof
    2.
    发明授权
    Pharmaceutical compositions of nicotine and methods of use thereof 有权
    尼古丁的药物组合物及其使用方法

    公开(公告)号：US07387788B1

    公开(公告)日：2008-06-17

    申请号：US11492568

    申请日：2006-07-24

    申请人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Celine Besse

    发明人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Celine Besse

    IPC分类号： A61K13/00 ,  A61K31/465

    CPC分类号： A61K31/465 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61K47/186 ,  A61K47/24 ,  A61K47/38

    摘要： The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between a pH of 5.5 and 7. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.

    摘要翻译： 本发明包括用于经皮递送尼古丁的非闭塞组合物，更具体地是其药学上可接受的盐，以及制备它们的方法。 组合物可以例如是适合于透皮或经粘膜应用的凝胶。 本发明的组合物通常包含水和醇的混合物，以及具有二甘醇单体烷基醚和二醇以特定比例和特定量存在的溶剂体系，其中凝胶的pH通常在pH 组合物可以包括另外的组分，例如，水醇载体可以进一步包含另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂（s） ）。 本发明还涉及一种用于持续递送尼古丁药学上可接受的盐以治疗多种病症和病症的方法。

    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS
    6.
    发明申请
    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS 审中-公开
    活性物质的超导传递系统

    公开(公告)号：US20110245215A1

    公开(公告)日：2011-10-06

    申请号：US13106715

    申请日：2011-05-12

    申请人： Dario Norberto R. Carrara ,  Arnaud Grenier ,  Celine Besse ,  Stephen M. Simes ,  Leah M. Lehman

    发明人： Dario Norberto R. Carrara ,  Arnaud Grenier ,  Celine Besse ,  Stephen M. Simes ,  Leah M. Lehman

    IPC分类号： A61K31/568 ,  A61P5/26 ,  A61P15/00

    CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/216 ,  A61K31/56 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

    摘要： A formulation for transdermal or transmucosal administration of an active agent. The formulation includes an active agent and a delivery vehicle comprising a C2 to C4 alkanol, a polyalcohol, and a permeation enhancer of monoalkyl ether of diethylene glycol present in an amount sufficient to provide permeation enhancement of the active agent through dermal or mucosal surfaces. The formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters in order to avoid undesirable odor and irritation effects caused by such compounds during use of the formulation. Also, the active agent is testosterone that is present in an amount of about 1%, the alkanol is ethanol that is present in an amount of about 46.28% to about 47.5% of the formulation; the polyalcohol is propylene glycol that is present in an amount of about 6% of the formulation; and the permeation enhancer is diethylene glycol monoethyl ether that is present in an amount of about 5% of the formulation.

    摘要翻译： 用于经皮或经粘膜施用活性剂的制剂。 该制剂包括活性剂和包含C2至C4链烷醇，多元醇和二甘醇单烷基醚的渗透促进剂的活性剂和递送载体，其量足以通过皮肤或粘膜表面提供活性剂的渗透增强。 制剂基本上不含长链脂肪醇，长链脂肪酸和长链脂肪酯，以避免在使用制剂期间由这些化合物引起的不希望的气味和刺激作用。 此外，活性剂是以约1％的量存在的睾酮，链烷醇是乙醇，其量为制剂的约46.28％至约47.5％; 多元醇是丙二醇，其存在量为制剂的约6％; 并且渗透增强剂是以制剂的约5％的量存在的二甘醇单乙醚。

    PHARMACEUTICAL COMPOSITIONS OF 5-ALPHA-REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
    7.
    发明申请
    PHARMACEUTICAL COMPOSITIONS OF 5-ALPHA-REDUCTASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
    5-ALPHA还原酶抑制剂的药物组合物及其使用方法

    公开(公告)号：US20090069364A1

    公开(公告)日：2009-03-12

    申请号：US12268301

    申请日：2008-11-10

    申请人： Dario Norberto R. Carrara ,  Arnaud Grenier

    发明人： Dario Norberto R. Carrara ,  Arnaud Grenier

    IPC分类号： A61K31/435

    CPC分类号： A61K9/7007 ,  A61K9/0014 ,  A61K9/006 ,  A61K9/06 ,  A61K31/025 ,  A61K31/435 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/946 ,  Y10S514/947

    摘要： Non-occlusive compositions for transdermal delivery of 5-alpha-reductase inhibitors, and more particularly finasteride or dutasteride or pharmaceutically acceptable salts or derivatives thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically include a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between about pH 4.5 and about pH 8. The compositions may include further components, for example, the hydroalcoholic vehicle may further include additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). Also, a method for the sustained delivery of 5-alpha-reductase inhibitors to treat a variety of conditions and disorders.

    摘要翻译： 用于透皮递送5-α-还原酶抑制剂的非闭塞组合物，更特别是非那雄胺或度他雄胺或其药学上可接受的盐或衍生物及其制备方法。 组合物可以例如是适合于透皮或经粘膜应用的凝胶。 本发明的组合物通常包括水和醇的混合物，以及具有二甘醇单体烷基醚和二醇以特定比例和特定量存在的溶剂体系，其中凝胶的pH通常在约pH 4.5和约pH 8.组合物可以包括其它组分，例如，水醇载体可以进一步包括另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂（ s）。 另外，用于持续递送5-α-还原酶抑制剂以治疗各种病症和障碍的方法。

    TRANSDERMAL COMPOSITIONS OF PRAMIPEXOLE HAVING ENHANCED PERMEATION PROPERTIES
    8.
    发明申请
    TRANSDERMAL COMPOSITIONS OF PRAMIPEXOLE HAVING ENHANCED PERMEATION PROPERTIES 审中-公开
    具有增强渗透性能的透明质酸酯组合物

    公开(公告)号：US20080176913A1

    公开(公告)日：2008-07-24

    申请号：US11770194

    申请日：2007-06-28

    申请人： Arnaud Grenier ,  Dario Norberto R. Carrara

    发明人： Arnaud Grenier ,  Dario Norberto R. Carrara

    IPC分类号： A61K31/4425 ,  A61P25/14

    CPC分类号： A61K31/428 ,  A61K9/0014

    摘要： A pharmaceutical composition for transdermal or transmucosal delivery of an active agent to treat a movement disorder such as Parkinson's disease. The composition provides enhanced transdermal or transmucosal delivery of the active agent by including an alkanolamine as a permeation enhancer with a carrier of water and at least one short-chain alcohol and with the composition having a neutral pH. The composition provides controlled and sustained release of the active agent suitable for daily administration.

    摘要翻译： 用于透皮或经粘膜递送活性剂以治疗运动障碍如帕金森病的药物组合物。 该组合物通过将含有水和至少一种短链醇的载体作为渗透促进剂的链烷醇胺和具有中性pH的组合物来提供增强的透皮或经粘膜递送活性剂。 组合物提供适于日常给药的活性剂的受控和持续释放。

    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS
    10.
    发明申请
    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS 审中-公开
    活性物质的超导传递系统

    公开(公告)号：US20110195114A1

    公开(公告)日：2011-08-11

    申请号：US13044447

    申请日：2011-03-09

    申请人： Dario Norberto R. Carrara ,  Arnaud Grenier

    发明人： Dario Norberto R. Carrara ,  Arnaud Grenier

    IPC分类号： A61K9/127 ,  A61K47/10 ,  A61K31/568 ,  A61K31/565 ,  A61P5/26 ,  A61P5/30 ,  A61P15/00 ,  A61P19/10

    CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/216 ,  A61K31/56 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

    摘要： A delivery vehicle for topical pharmaceutical formulations that include a C2 to C4 alkanol, a polyalcohol, and a monoalkyl ether of diethylene glycol present in relative amounts sufficient to provide permeation enhancement of an active agent through mammalian dermal or mucosal surfaces. Preferably, the delivery vehicle as well as the formulations that contain it are substantially free of long-chain fatty alcohols, long-chain fatty acids and long-chain fatty esters in order to avoid potential undesirable odor and irritation effects caused by such compounds during use of the formulation. Without these additives, use of the formulations is facilitated and patient compliance is greater

    摘要翻译： 用于局部药物制剂的递送载体，其包含C2至C4链烷醇，多元醇和二甘醇的单烷基醚，其量相当于通过哺乳动物皮肤或粘膜表面提供活性剂的渗透增强。 优选地，输送载体以及含有它的制剂基本上不含长链脂肪醇，长链脂肪酸和长链脂肪酸酯，以避免在使用期间由这些化合物引起的潜在的不良气味和刺激作用 的配方。 没有这些添加剂，便于使用制剂，并且患者依从性更大