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公开(公告)号：US20130030367A1
公开(公告)日：2013-01-31
申请号：US13607659
申请日：2012-09-07
IPC分类号： A61M5/20
CPC分类号： A61M5/30 , A61K9/0019 , A61K9/0087 , A61K31/519 , A61K31/568 , A61M5/178 , A61M5/2033 , A61M5/3202 , A61M5/326 , A61M2005/2013 , A61M2005/2073 , A61M2005/3247
摘要： A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.
摘要翻译： 一种危险剂注射系统，包括约0.02ml至约4.0ml浓度为约7.5mg / ml至约150mg / ml的甲氨蝶呤; 一种针辅助喷射喷射器，其包括容纳甲氨蝶呤的容器; 与所述容器相关联的注射出口构件; 注射辅助针，其联接到所述注射出口构件; 与容器相关联的击发机构; 与发射机构相关联的能量源; 以及与所述击发机构相关联的触发机构，其中所述针辅助喷射器被配置为从所述注射出口构件喷射所述甲氨蝶呤，使得针刺喷射的甲氨蝶呤的C max，T max和生物利用度落在约80％和 用手动注射器输送的甲氨蝶呤的Cmax，Tmax和生物利用度的约125％。
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公开(公告)号：US07776015B2
公开(公告)日：2010-08-17
申请号：US11002687
申请日：2004-12-03
申请人： Peter L. Sadowski , David M. Deboer , Claude L. Berman , Paul R. Lesch, Jr. , Margaret L. Holland
发明人： Peter L. Sadowski , David M. Deboer , Claude L. Berman , Paul R. Lesch, Jr. , Margaret L. Holland
IPC分类号： A61M37/00
CPC分类号： A61M5/326 , A61M5/002 , A61M5/20 , A61M5/24 , A61M5/2425 , A61M5/2466 , A61M5/282 , A61M5/288 , A61M5/30 , A61M5/3202 , A61M5/3232 , A61M5/3243 , A61M5/3286 , A61M5/349 , A61M2005/3247 , A61M2205/583
摘要： A jet injection device with a fluid chamber in a housing member for holding about 0.02 ml to about 3 ml of a medicament. An injection-assisting needle has an injection end that extends from the housing for inserting into a patient to a depth of up to about 5 mm. A force-generating source is configured to apply a pressure reaching about 100-1000 psi to the medicament in the chamber to expel the medicament through the injecting end of the needle.
摘要翻译： 一种喷射装置，其具有用于容纳约0.02ml至约3ml药物的壳体构件中的流体室。 注射辅助针具有从壳体延伸以插入患者到达约5mm的深度的注射端。 力产生源被配置为向腔室中的药物施加达到约100-1000psi的压力，以通过针的注射端排出药物。
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公开(公告)号：US20090292240A1
公开(公告)日：2009-11-26
申请号：US12299274
申请日：2007-05-02
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/2466 , A61M5/30 , A61M5/3202 , A61M5/3204 , A61M5/326 , A61M2005/2013 , A61M2005/2073 , A61M2005/2474 , A61M2005/3125
摘要： An injector for injecting a medicament into a patient. The injector includes a container defining a first chamber, which contains a fluid therein, and a second chamber. The injector also includes an injection conduit configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.
摘要翻译： 一种用于将药物注射到患者体内的注射器。 喷射器包括限定在其中包含流体的第一室的容器和第二室。 注射器还包括注射管道，其被配置用于将从容器中喷出的流体引导到患者体内。 传送机构可由用户操作以在第一操作阶段将流体从第一腔室传送到第二腔室，并且击发机构可由使用者操作，用于通过喷射导管从第二腔室喷射流体 第二阶段运作。 一个能量源与击发机构相关联，以驱动第一和第二阶段的击发机构。
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公开(公告)号：US08579865B2
公开(公告)日：2013-11-12
申请号：US13257555
申请日：2010-03-19
CPC分类号： A61M5/30 , A61K9/0019 , A61K9/0087 , A61K31/519 , A61K31/568 , A61M5/178 , A61M5/2033 , A61M5/3202 , A61M5/326 , A61M2005/2013 , A61M2005/2073 , A61M2005/3247
摘要： Injection systems comprising a powered injector and one or more hazardous agents are disclosed.
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公开(公告)号：US08419686B2
公开(公告)日：2013-04-16
申请号：US13427969
申请日：2012-03-23
IPC分类号： A61M37/00
CPC分类号： A61M5/3204 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/2459 , A61M5/3134 , A61M5/3202 , A61M5/326 , A61M5/425 , A61M2005/206 , A61M2005/2073 , A61M2005/3118
摘要： An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.
摘要翻译： 一种注射装置，其包括被配置为容纳要注射的物质的腔室和与腔室可操作地相关联并且具有足以将物质输送到皮内注射部位的长度的针。 衣领围绕针，限定一个衣领腔。 套环还具有外围的向前皮肤接触表面，该表面围绕并且与针和注射部位径向间隔开足够大的区域，以允许患者的皮肤移动到套环空腔中以适当地定位针以便皮内递送 该物质到注射部位以允许将注射物质扩散到皮肤下，同时抑制或防止皮肤内的背压，从而迫使物质通过注射部位。
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公开(公告)号：US20130018313A1
公开(公告)日：2013-01-17
申请号：US13184229
申请日：2011-07-15
申请人： Thomas Kramer , Matthew Howard Rust , Paul Michael Goudreau , Peter Anthony Hoeft , Julius Craig Sund , Peter L. Sadowski
发明人： Thomas Kramer , Matthew Howard Rust , Paul Michael Goudreau , Peter Anthony Hoeft , Julius Craig Sund , Peter L. Sadowski
IPC分类号： A61M5/20
CPC分类号： A61M5/5086 , A61M5/2033 , A61M5/30 , A61M5/3007 , A61M5/3204 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/3247 , A61M2205/584
摘要： An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.
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公开(公告)号：US06565553B2
公开(公告)日：2003-05-20
申请号：US10062652
申请日：2002-01-31
IPC分类号： A61M3100
CPC分类号： A61M5/326 , A61M5/002 , A61M5/20 , A61M5/24 , A61M5/2425 , A61M5/2466 , A61M5/282 , A61M5/288 , A61M5/30 , A61M5/3202 , A61M5/3232 , A61M5/3243 , A61M5/3286 , A61M5/349 , A61M2005/3247 , A61M2205/583
摘要： The invention relates to methods and devices for delivering medicament by jet injection to an injection site in a patient. The method includes inserting a needle into an insertion point, wherein the needle has a length of less than 5 mm and is operatively associated with an orifice in a nozzle assembly in fluid communication with an ampule chamber containing the medicament. The needle extends less than about 5 mm from the nozzle assembly orifice when the medicament is expelled. Next, a force generating mechanism is activated, and a pressure wall member that is operatively associated with the force generating member moves in response to the activation of the force generating mechanism at a speed sufficient to jet inject the medicament from the ampule chamber through the orifice and needle under a pressure of less than about 4000 psi to deliver a substantial portion of the medicament through the needle and past the insertion point to the injection site. The needle tip maybe part of a retractable needle of a jet injection device, or is part of a fixed needle of a jet injection device.
摘要翻译： 本发明涉及通过射流注射将药物输送到患者的注射部位的方法和装置。 该方法包括将针插入插入点，其中针具有小于5mm的长度并且与喷嘴组件中的孔口可操作地相关联，该喷嘴组件与容纳药物的安瓿室流体连通。 当药物被排出时，针从喷嘴组件孔口延伸小于约5mm。 接下来，启动力产生机构，并且与力产生构件可操作地相关联的压力壁构件响应于力产生机构的激活而移动，其速度足以喷射从安瓿室喷射药物通过孔 和针在小于约4000psi的压力下，以将大部分药物通过针输送并穿过插入点至注射部位。 针尖可以是喷射装置的可缩回针的一部分，或者是喷射装置的固定针的一部分。
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公开(公告)号：US20130303985A1
公开(公告)日：2013-11-14
申请号：US13857859
申请日：2013-04-05
申请人： Paul K. Wotton , Kaushik J. Dave , John W. Hayes , Peter L. Sadowski , Hermanus L. Jooste , Jonathan Jaffe
发明人： Paul K. Wotton , Kaushik J. Dave , John W. Hayes , Peter L. Sadowski , Hermanus L. Jooste , Jonathan Jaffe
CPC分类号： A61M5/425 , A61K9/0019 , A61K31/56 , A61K31/568 , A61M5/002 , A61M5/2033 , A61M5/30 , A61M5/3153 , A61M5/3202 , A61M5/326 , A61M5/44 , A61M37/00 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2205/3613 , A61M2205/364 , A61M2205/3673
摘要： The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.
摘要翻译： 本发明提供用于治疗需要用睾丸酮治疗的受试者的组合物和方法，包括从针刺辅助喷射装置皮下，皮内或肌内引入睾酮。
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公开(公告)号：US08496619B2
公开(公告)日：2013-07-30
申请号：US13184229
申请日：2011-07-15
申请人： Thomas Kramer , Matthew Howard Rust , Paul Michael Goudreau , Peter Anthony Hoeft , Julius Craig Sund , Peter L. Sadowski
发明人： Thomas Kramer , Matthew Howard Rust , Paul Michael Goudreau , Peter Anthony Hoeft , Julius Craig Sund , Peter L. Sadowski
IPC分类号： A61M5/20
CPC分类号： A61M5/5086 , A61M5/2033 , A61M5/30 , A61M5/3007 , A61M5/3204 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/3247 , A61M2205/584
摘要： An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.
摘要翻译： 本公开的示例性实施例可以提供包括触发机构，能量源和用户可操作的起火构件的喷射器。 触发器构件可以包括具有保持器部分的触发器构件，以及具有构造成对药物容器进行加压以从其中排出药物的冲头的冲头组件，以及触发器接合构件，其构造成以预定位置接合触发构件的保持器部分， 点火条件。 能量源可以与冲头相关联，以驱动冲头以排出药物，并且用户可操作的起火构件可操作用于在触发器接合构件和保持器部分之间从预燃烧状态引起轴向旋转 到触发接合构件从保持器部分释放以允许能量源对冲头起动的点火状态。
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公开(公告)号：US20120179100A1
公开(公告)日：2012-07-12
申请号：US13427969
申请日：2012-03-23
CPC分类号： A61M5/3204 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/2459 , A61M5/3134 , A61M5/3202 , A61M5/326 , A61M5/425 , A61M2005/206 , A61M2005/2073 , A61M2005/3118
摘要： An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.
摘要翻译： 一种注射装置，其包括被配置为容纳要注射的物质的腔室和与腔室可操作地相关联并且具有足以将物质输送到皮内注射部位的长度的针。 衣领围绕针，限定一个衣领腔。 套环还具有外围的向前皮肤接触表面，该表面围绕并且与针和注射部位径向间隔开足够大的区域，以允许患者的皮肤移动到套环空腔中以适当地定位针以便皮内递送 该物质到注射部位以允许将注射物质扩散到皮肤下，同时抑制或防止皮肤内的背压，从而迫使物质通过注射部位。
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