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公开(公告)号：US20050119181A1
公开(公告)日：2005-06-02
申请号：US10956724
申请日：2004-10-01
申请人： R. Pepinsky , Alphonse Galdes , Ellen Garber , Darren Baker , Jeffery Porter , Frederick Taylor , Kevin Williams , Russell Petter , Kathryn Strauch , Paul Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Pepinsky , Alphonse Galdes , Ellen Garber , Darren Baker , Jeffery Porter , Frederick Taylor , Kevin Williams , Russell Petter , Kathryn Strauch , Paul Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
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公开(公告)号：US08129425B2
公开(公告)日：2012-03-06
申请号：US11412424
申请日：2006-04-27
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： A61K31/381 , C07D333/52
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。
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3.发明申请Inhibitors of hedgehog signaling pathways, compositions and uses related thereto 审中-公开刺猬蛋白信号通路抑制剂，组合物和与之相关的用途公开(公告)号：US20060142245A1
公开(公告)日：2006-06-29
申请号：US11270984
申请日：2005-11-11
申请人： Philip Beachy , Michael Cooper , Jeffery Porter
发明人： Philip Beachy , Michael Cooper , Jeffery Porter
IPC分类号： A61K31/695 , A61K31/66 , A61K31/56
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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公开(公告)号：US20060287385A1
公开(公告)日：2006-12-21
申请号：US11412424
申请日：2006-04-27
申请人： Anthony Baxter , Edward Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Stibbard
发明人： Anthony Baxter , Edward Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Stibbard
IPC分类号： A61K31/381 , C07D333/56 , C07D333/72 , C07D409/02
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
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公开(公告)号：US20050070578A1
公开(公告)日：2005-03-31
申请号：US10491225
申请日：2002-09-18
申请人： Anthony Baxter , Edward Boyd , Maria Frank-Kamenetsky , Jeffery Porter , Stephen Price , Lee Rubin , John Stibbard
发明人： Anthony Baxter , Edward Boyd , Maria Frank-Kamenetsky , Jeffery Porter , Stephen Price , Lee Rubin , John Stibbard
IPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14 , A61K31/4025 , C07D333/56 , C07D49/02
CPC分类号： C07D409/12 , A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。
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公开(公告)号：US08852937B2
公开(公告)日：2014-10-07
申请号：US11894557
申请日：2007-08-20
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： C12N5/00 , A01N43/12 , A01N43/06 , A01N43/64 , C07D409/14 , C07D333/70 , A61K31/4436 , A61K31/44 , A61K31/517 , A61K31/50 , A61K31/422 , A61K31/381 , C07D409/12
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。
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公开(公告)号：US20080207740A1
公开(公告)日：2008-08-28
申请号：US11894557
申请日：2007-08-20
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： A61K31/381 , C12N5/06
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 32和33。 在某些实施方案中，可以使用所述方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。
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公开(公告)号：US07115653B2
公开(公告)日：2006-10-03
申请号：US10245844
申请日：2002-09-17
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee L. Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee L. Rubin , John Harry Alexander Stibbard
IPC分类号： A61K31/381 , C07D333/52
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 32和33。 在某些实施方案中，可以使用所述方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。
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