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公开(公告)号：US20240009332A1
公开(公告)日：2024-01-11
申请号：US18228818
申请日：2023-08-01
发明人： Bashir Akhavan TAFTI
CPC分类号： A61K51/1251 , A61K9/51 , A61K49/1887 , A61N5/10 , A61N2005/109
摘要： The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.
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公开(公告)号：US20240350684A1
公开(公告)日：2024-10-24
申请号：US18609663
申请日：2024-03-19
发明人： Bashir Akhavan TAFTI
CPC分类号： A61K51/1251 , A61K51/0497 , A61K51/088 , A61N5/1002 , A61P35/00 , A61N2005/1021 , A61N2005/1087
摘要： The present disclosure features radiopharmaceutical compositions including a radionuclide and an imaging agent encapsulated within, embedded in, or conjugated to a nanoparticle (e.g., via a complexing moiety, such as a chelator), and methods of their use. The radiopharmaceuticals may be formulated for direct administration to the diseased tissue, with minimal or no washout of the radiopharmaceutical to non-target sites within a subject. The radiopharmaceuticals of the present disclosure allow for efficient treatment of diseased tissue proximal to the site of administration with minimal to no damage to the surrounding tissue.
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