公开(公告)号：US20240342507A1

公开(公告)日：2024-10-17

申请号：US18133962

申请日：2023-04-12

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Ammar Sarwar ,  Joseph Ring

IPC分类号： A61N5/10 ,  A61K51/12 ,  G16H10/60

CPC分类号： A61N5/1071 ,  A61K51/1251 ,  A61N5/1002 ,  A61N5/1007 ,  G16H10/60 ,  A61N2005/1021

摘要： A microsphere delivery apparatus providing real-time measuring of delivered radioactivity during medical procedures utilizing radioactive emitting microspheres wherein an administration housing includes a holder to receive a vial containing microspheres for delivery to a patient, a detector holder to receive a radiation detector and a delivery tube assembly for transporting fluid containing the microspheres.

公开(公告)号：US12005272B1

公开(公告)日：2024-06-11

申请号：US17175805

申请日：2021-02-15

申请人： James R Crowley

发明人： James R Crowley

IPC分类号： A61N5/10 ,  G01T1/18

CPC分类号： A61N5/1071 ,  A61N5/1001 ,  G01T1/18 ,  A61N2005/1021

摘要： Certain configurations are described of devices that can receive and retain a radiation measuring device during administration of a nuclear medication. In some instances, the radiation measuring device can measure radiation levels being delivered through an intravenous line positioned within the device and connected to a patient. Methods and systems using the devices are also described.

公开(公告)号：US11752254B2

公开(公告)日：2023-09-12

申请号：US16334882

申请日：2017-09-20

申请人： BRACCO DIAGNOSTICS INC.

发明人： Clif Moyers ,  Adrian Nunn ,  Andrew Schimmoeller ,  Brian Cherundolo

IPC分类号： A61M5/00 ,  G21G4/08 ,  A61N5/10 ,  A61M5/142 ,  G01T1/16 ,  A61K51/12 ,  G21F5/015 ,  G21G1/00 ,  A61M5/14 ,  A61M5/162 ,  A61M5/168 ,  G01T1/20 ,  G21H5/02 ,  G01T7/00

CPC分类号： A61M5/007 ,  A61K51/121 ,  A61K51/1282 ,  A61M5/142 ,  A61M5/1408 ,  A61M5/162 ,  A61M5/16827 ,  A61M5/16881 ,  A61N5/1007 ,  G01T1/20 ,  G01T7/005 ,  G21F5/015 ,  G21G1/0005 ,  G21G4/08 ,  G21H5/02 ,  A61K2123/00 ,  A61M2205/18 ,  A61M2205/3313 ,  A61M2205/3389 ,  A61M2205/702 ,  A61N2005/1021 ,  G01T1/1603 ,  G21G2001/0031

摘要： A nuclear medicine infusion system (10) may be used to generate and infuse radioactive liquid into a patient undergoing a diagnostic imaging procedure. In some examples, the infusion system includes a frame (30) that carries a radioisotope generator (52) that generates radioactive eluate via elution. The frame may also carry a beta detector (58) and a gamma detector (60). The beta detector can be positioned to measure beta emissions emitted from the radioactive eluate supplied by the generator. The gamma detector can be positioned to measure gamma emissions emitted from a portion of the radioactive eluate to evaluate a safety of the radioactive eluate delivered by the infusion system.

公开(公告)号：US11745028B2

公开(公告)日：2023-09-05

申请号：US16868021

申请日：2020-05-06

申请人： ADAPTIIV MEDICAL TECHNOLOGIES INC.

发明人： Christopher Majcher ,  Borko Basaric ,  James L. Robar

IPC分类号： A61N5/10 ,  G06F30/10 ,  B33Y80/00 ,  B33Y50/00 ,  B29C64/386 ,  B29L31/00 ,  G06Q50/04

CPC分类号： A61N5/1028 ,  B29C64/386 ,  B33Y50/00 ,  G06F30/10 ,  A61N2005/1021 ,  B29L2031/753 ,  B33Y80/00 ,  G06Q50/04

摘要： Systems and methods are provided for generating surface brachytherapy applicators in which catheter channel trajectories are generated laterally from both sides of a cut plane bisecting an initial model of the surface brachytherapy applicator model, thereby mitigating the effects of patient-surface-induced curvature. The catheter channels may be defined based on catheter channel trajectories that are spatially distributed, relative to the cut plane, on both sides of the cut plane, and spatially offset relative to a patient-facing surface of the surface brachytherapy applicator model. In some example embodiments, catheter channel trajectories are spaced relative to the cut plane such that neighbouring catheter channel trajectories are evenly spaced along a set of contours. Prior to fabrication, the local radius of curvature of catheter channels may be adjusted in a manual or automated manner to exceed a threshold.

公开(公告)号：US20190018149A1

公开(公告)日：2019-01-17

申请号：US16070698

申请日：2017-01-18

申请人： SURGICEYE GMBH

发明人： Joerg TRAUB ,  Philipp MATTHIES ,  Matthias KEICHER

IPC分类号： G01T1/161 ,  G01T1/02 ,  A61N5/10

CPC分类号： G01T1/161 ,  A61N5/1048 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1076 ,  G01T1/02 ,  G01T1/1603

摘要： An image generating apparatus for image generation and dose calculation is provided. The image generating apparatus includes a movable detector for detecting nuclear radiation during a detection period and an evaluation system. The evaluation system includes an interface system for transmitting detector data to the evaluation system. The detector data include information about the detected radiation for image generation. The evaluation system further includes a data memory portion for storing the detector data. The evaluation system further includes a program memory portion with a program for repeatedly determining at least one quality value with respect to image generation during the detection period. The image generating apparatus includes an output system including at least one output unit. The at least one output unit includes one output unit for outputting an instruction to a user for further moving the detector in dependence of the detector data. The instruction relates to at least a part of the remaining detection period.

公开(公告)号：US10016620B2

公开(公告)日：2018-07-10

申请号：US15388449

申请日：2016-12-22

申请人： PROCEPT BioRobotics Corporation

发明人： Nikolai Aljuri ,  Rodney Perkins ,  Surag Mantri

IPC分类号： A61N5/10 ,  A61B18/14 ,  A61B10/02 ,  A61B90/00 ,  A61B5/00 ,  A61B17/3203 ,  A61M25/10 ,  A61B5/06 ,  A61B18/12 ,  A61B18/22 ,  A61M1/00 ,  A61M25/00 ,  A61B8/12 ,  G01N33/574 ,  A61B18/16 ,  A61B18/00 ,  A61B18/04

CPC分类号： A61N5/1015 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/061 ,  A61B8/085 ,  A61B8/12 ,  A61B10/02 ,  A61B10/0241 ,  A61B17/3203 ,  A61B17/32037 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/16 ,  A61B18/22 ,  A61B90/06 ,  A61B90/37 ,  A61B2010/0225 ,  A61B2017/32032 ,  A61B2018/0022 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61B2018/00863 ,  A61B2018/046 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/067 ,  A61B2090/378 ,  A61B2090/508 ,  A61B2217/005 ,  A61B2217/007 ,  A61B2218/002 ,  A61B2218/007 ,  A61B2505/05 ,  A61B2562/0219 ,  A61M1/008 ,  A61M25/0017 ,  A61M25/10182 ,  A61M25/10185 ,  A61M2205/0216 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2210/166 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1011 ,  A61N2005/1021 ,  A61N2005/1024 ,  A61N2005/1094 ,  G01N33/57434

摘要： A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.

公开(公告)号：US20180126012A1

公开(公告)日：2018-05-10

申请号：US15809427

申请日：2017-11-10

申请人： Wisconsin Alumni Research Foundation

发明人： Jamey Weichert ,  Paul Sondel ,  Ravi Patel ,  Zachary Morris ,  Peter Carlson ,  Reinier Hernandez ,  Joseph Grudzinski

IPC分类号： A61K51/04 ,  A61P35/00 ,  A61K41/00 ,  A61K51/10 ,  A61K9/00 ,  A61P35/04 ,  A61K38/20 ,  A61K39/395

CPC分类号： A61K51/0485 ,  A61K9/0019 ,  A61K38/2013 ,  A61K39/39541 ,  A61K39/39558 ,  A61K41/0038 ,  A61K51/0408 ,  A61K51/0489 ,  A61K51/0497 ,  A61K51/1045 ,  A61K2039/505 ,  A61N5/00 ,  A61N5/1001 ,  A61N2005/1021 ,  A61P35/00 ,  A61P35/04 ,  A61P37/04 ,  C07K14/52 ,  C07K16/2818 ,  C07K16/3084 ,  C07K2319/35 ,  A61K2300/00

摘要： The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid ether metal chelate, a radiohalogenated phospholipid ether, or other targeted radiotherapy (TRT) agent that is differentially retained within malignant solid tumor tissue, and either (a) performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or (b) performing immunotherapy in the subject by systemically administering to the subject an immunostimulatory agent, such as an immune checkpoint inhibitor. In a non-limiting example, the radioactive phospholipid ether metal chelate or radiohalogenated phospholipid ether has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half-life of greater than 6 hours and less than 30 days, or wherein R1 comprises a radioactive halogen isotope. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

公开(公告)号：US09839705B2

公开(公告)日：2017-12-12

申请号：US15402791

申请日：2017-01-10

申请人： MO-SCI CORPORATION

发明人： Delbert E. Day ,  Yiyong He

IPC分类号： A61K51/12 ,  A61K9/00 ,  A61B6/03 ,  A61B6/00 ,  A61N5/10

CPC分类号： A61K51/1255 ,  A61B6/037 ,  A61B6/4057 ,  A61K9/0019 ,  A61K51/025 ,  A61K51/1244 ,  A61N5/1001 ,  A61N2005/1021

摘要： This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging.

公开(公告)号：US09808543B2

公开(公告)日：2017-11-07

申请号：US14600738

申请日：2015-01-20

申请人： UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Anthony J. Di Pasqua ,  Kenneth J. Balkus, Jr. ,  Imalka S. Munaweera ,  Yi Shi

IPC分类号： A61K51/12 ,  A61K33/24 ,  A61K31/555 ,  A61K45/06 ,  A61K33/00 ,  A61K33/22 ,  A61K33/26 ,  A61K33/38 ,  A61K38/18 ,  A61K38/19 ,  A61K38/27 ,  A61K38/30 ,  A61N5/10

CPC分类号： A61K51/1244 ,  A61K31/555 ,  A61K33/00 ,  A61K33/22 ,  A61K33/24 ,  A61K33/26 ,  A61K33/38 ,  A61K38/18 ,  A61K38/193 ,  A61K38/27 ,  A61K38/30 ,  A61K45/06 ,  A61K51/1275 ,  A61K2300/00 ,  A61N5/1007 ,  A61N5/1029 ,  A61N2005/1021

摘要： Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

公开(公告)号：US20170296839A1

公开(公告)日：2017-10-19

申请号：US15635258

申请日：2017-06-28

申请人： Covidien LP

发明人： Brian M. Strauss ,  Jeffrey J. Valko

IPC分类号： A61N5/10 ,  A61B18/00

CPC分类号： A61N5/1002 ,  A61B17/00491 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B18/00 ,  A61B2017/00898 ,  A61B2017/00942 ,  A61B2018/00577 ,  A61N5/1007 ,  A61N2005/1021 ,  A61N2005/1098

摘要： A method of radio-ablation in conjunction with embolic implants used for pre-embolization of branch arteries in radio-ablation of the liver or other diseased tissue.