公开(公告)号：US11648260B2

公开(公告)日：2023-05-16

申请号：US17042441

申请日：2019-03-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Shulamit Levenberg ,  Shaowei Guo ,  Daniel Offen ,  Nisim Perets

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113 ,  A61K9/50 ,  C12N15/11 ,  A61K9/127

CPC classification number: A61K31/713 ,  A61K9/5068 ,  A61K35/28 ,  A61K38/51 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  A61K9/127 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2310/531 ,  C12N2320/32

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

公开(公告)号：US11129852B2

公开(公告)日：2021-09-28

申请号：US16325445

申请日：2017-08-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel Offen ,  Nisim Perets

IPC: A61K35/28 ,  A61P25/28 ,  A61P25/18 ,  A61K9/00 ,  A61K9/127

Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.

公开(公告)号：US20230330130A1

公开(公告)日：2023-10-19

申请号：US18194163

申请日：2023-03-31

Applicant: Technion Research and Development Foundation Limited ,  Ramot At Tel-Aviv University Ltd.

Inventor： Shulamit Levenberg ,  Shaowei Guo ,  Daniel Offen ,  Nisim Perets

IPC: A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113 ,  A61K9/50 ,  C12N15/11

CPC classification number: A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/1137 ,  A61K9/5068 ,  C12N15/111 ,  C12N15/113 ,  A61K9/127

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.