公开(公告)号：US20170190098A1

公开(公告)日：2017-07-06

申请号：US15248354

申请日：2016-08-26

Applicant: RAPHAS Co., Ltd.

Inventor： Hong Kee KIM ,  Jung Dong KIM ,  Jung Hyun BAE ,  Yang Gi LEE ,  So Hyun PARK ,  Do Hyeon JEONG

IPC: B29C55/00 ,  B29C37/00 ,  B29C33/30 ,  A61M37/00

Abstract: A manufacturing device for a microneedle includes an upper plate stage, a lower plate stage disposed in horizontally parallel with the upper plate stage, a rotating device configured to rotate and move the upper plate stage over the lower plate stage, and a first cylindrical type actuator configured to vertically move the lower plate stage in a state in which the upper plate stage has been rotated and moved over the lower plate stage by the rotating device. The first cylindrical type actuator may upwardly and downwardly move so as to be able to stretch a viscous composition in a vertical direction in a state in which a contacting to the viscous composition is performed, wherein the viscous composition is applied on both of a patch sheet seated on the upper plate stage and a patch sheet seated on the lower plate stage, or is applied on one of them.

公开(公告)号：US20220104748A1

公开(公告)日：2022-04-07

申请号：US17552954

申请日：2021-12-16

Applicant: RAPHAS CO., LTD.

Inventor： Keun Ho LEE ,  Eun Jin AN ,  Jung Hyun BAE ,  Jung Dong KIM ,  Do Hyeon JEONG

IPC: A61B5/262 ,  C08G65/26

Abstract: The present disclosure relates to a microneedle array for bio-sensing or a biosensor using the microneedle array. The microneedle array for bio-sensing does not include an additional electrode or an additional conductive coating, have a solid structure, and is homogeneous throughout the solid structure. The microneedle array for bio-sensing is composed of a material including poly (3,4-ethylendeddioxythiophene):poly (styrenesulfonate) (PEDOT:PSS).

公开(公告)号：US20210345996A1

公开(公告)日：2021-11-11

申请号：US17380258

申请日：2021-07-20

Applicant: RAPHAS CO., LTD.

Inventor： Keun Ho LEE ,  Eun Jin AN ,  Seong Jin KIM ,  Chang Yub SUNG ,  Jung Dong KIM ,  Do Hyeon JEONG ,  Kwang Hoon LEE

IPC: A61B10/02 ,  A61L31/04

Abstract: The present disclosure relates to a minimally-invasive skin biopsy method. The minimally-invasive skin biopsy method according to the present disclosure includes: preparing a microneedle patch; attaching the microneedle patch to a skin of an object; maintaining a state in which the microneedle patch is attached to the skin of the object for a predetermined period of time; and detaching the microneedle patch from the skin of the object after the predetermined period of time, and analyzing a protein component of the object, which adheres to a microneedle of the microneedle patch. The microneedle is made of a biocompatible polymer substance.

公开(公告)号：US20210290922A1

公开(公告)日：2021-09-23

申请号：US17343061

申请日：2021-06-09

Applicant: RAPHAS CO., LTD.

Inventor： Ju Young JIN ,  Moon Su LEE ,  Tae Hyung KIM ,  Jung Dong KIM ,  Do Hyeon JEONG

IPC: A61M37/00 ,  B29D99/00 ,  G01N11/02

Abstract: A method of manufacturing a microneedle includes selecting and providing a microneedle material whose viscosity/elastic modulus measured for each shear rate using a viscoelasticity measuring equipment falls in a range between a predetermined upper limit and a predetermined lower limit, and manufacturing the microneedle using the microneedle material by an extension process.

公开(公告)号：US20230148950A1

公开(公告)日：2023-05-18

申请号：US17995559

申请日：2020-06-11

Applicant: RAPHAS CO., LTD.

Inventor： Do Hyeon JEONG ,  Jung Dong KIM ,  Keun Ho LEE ,  Kwang Hoon LEE

IPC: A61B5/00 ,  G01N33/68 ,  G01N33/573 ,  A61B10/02

CPC classification number: A61B5/445 ,  A61B5/685 ,  A61B10/02 ,  G01N33/573 ,  G01N33/6869 ,  G01N2333/5406 ,  G01N2333/5437 ,  G01N2800/202

Abstract: A minimally-invasive atopic dermatitis test method comprises the steps of: applying, to the skin of a subject, a microneedle patch including a plurality of microneedles made of a biodegradable hyaluronic acid polymer and having a solid core structure and a bottom layer which is a base on which the plurality of microneedles are formed; maintaining the microneedle patch attached to the skin of the subject for a predetermined time; separating the microneedle patch from the skin of the subject after a predetermined time has passed to input the microneedle patch to a quantitative test; reading the amount of interleukin-4 and interleukin-13 adsorbed onto the surface of the microneedles of the microneedle patch in the quantitative test step; and evaluating atopic dermatitis activity on the basis of the reading of the amount of interleukin-4 and interleukin-13.

公开(公告)号：US20170156935A1

公开(公告)日：2017-06-08

申请号：US15248339

申请日：2016-08-26

Applicant: RAPHAS Co., Ltd.

Inventor： Hong Kee KIM ,  Jung Dong KIM ,  Jung Hyun BAE ,  Yang Gi LEE ,  So Hyun PARK ,  Do Hyeon JEONG

IPC: A61F13/02 ,  B32B37/12 ,  A61K9/00 ,  B32B38/10

CPC classification number: A61F13/0276 ,  A61F2013/0296 ,  A61K9/0021 ,  B32B37/12 ,  B32B38/10 ,  B32B2535/00

Abstract: A manufacturing method of a microstructure includes providing a patch manufacturing sheet formed in a state in which a bottom layer is exposed on an upper part thereof; providing the patch manufacturing sheet on a first process substrate and a second process substrate; spotting a viscous composition at a plurality of positions spaced apart from each other on the bottom layer of the patch manufacturing sheet provided on only the first process substrate, or provided on both of the first process substrate and the second process substrate; contacting the patch manufacturing sheet provided on the second process substrate or the viscous composition to the viscous composition spotted on the patch manufacturing sheet provided on the first process substrate; moving relatively the second process substrate with respect to the first process substrate to stretch the viscous composition and to coagulate the stretched viscous composition; and cutting the coagulated viscous composition.