公开(公告)号：US20240358279A1

公开(公告)日：2024-10-31

申请号：US18771659

申请日：2024-07-12

Applicant: BLINK DEVICE LLC

Inventor： Justin HULVERSHORN ,  Karl SCHMIDT ,  Tyler HART

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/24 ,  A61B5/294 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61N1/04 ,  G16H10/60 ,  G16H50/20

CPC classification number: A61B5/1106 ,  A61B5/24 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7217 ,  A61B5/294 ,  A61B2560/0238 ,  A61B2562/0219 ,  A61N1/0456 ,  G16H10/60 ,  G16H50/20

Abstract: Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four ratio.

公开(公告)号：US12109019B2

公开(公告)日：2024-10-08

申请号：US18542386

申请日：2023-12-15

Applicant: Adaptyx Biosciences, Inc.

Inventor： Alexander Yoshikawa ,  Vijit Sabnis ,  Pawan Kapur ,  Vladimir Kesler ,  Donald A. Ice ,  George M. Mihalakis

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1459

CPC classification number: A61B5/14546 ,  A61B5/1459 ,  A61B5/685 ,  A61B5/725

Abstract: The present disclosure provides systems and methods to monitor analytes present in a biological sample of a subject using a piercing element coupled to a support configured to pierce a body surface of the subject, an analyte binding probe on or within the piercing to provide a change in an optical signal when contacting an analyte in the biological sample of the subject, and a detector configured to detect the optical signal.

公开(公告)号：US20240285236A1

公开(公告)日：2024-08-29

申请号：US18586283

申请日：2024-02-23

Applicant: AQUILX INCORPORATED

Inventor： Farshad Tehrani ,  Hazhir Teymourian ,  Brian Wuerstle

IPC: A61B5/00 ,  A61B5/1486

CPC classification number: A61B5/685 ,  A61B5/0004 ,  A61B5/14865 ,  A61B5/6833 ,  A61B5/6885

Abstract: An improved wearable biosensor device having emergent properties such as extended wear life, elimination or significant reduction of warm-up time, a user-friendly insertion process that ensures secure skin-locking immediately post-insertion, enhanced durability of microneedles against breakage, superior user experience and comfort during wear, and improved scalable manufacturability. Together, these innovations not only elevate the sensor's overall performance but also its accuracy, functionality, and reliability. This novel design and functionality guarantees that the wearable biosensor device is more efficient, provides a better experience for users and establishes a new benchmark in the industry.

公开(公告)号：US12064266B2

公开(公告)日：2024-08-20

申请号：US17265438

申请日：2019-08-02

Applicant: PKvitality

Inventor： Luc Pierart ,  Anh-Minh Lê

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/15

CPC classification number: A61B5/685 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/6824 ,  A61B5/6831 ,  A61B5/6833 ,  A61B5/6839 ,  A61B5/6886 ,  A61B2560/0412 ,  A61B2562/0295

Abstract: A sensor (220) for a body monitoring system (1), having analyte-measuring microneedles (210) that extend parallel to a main direction (Z) from a substrate (242) and define a working plane (Pt), wherein the sensor (220) has at least one conductivity electrode (600) with a metallic track (602), the end of the metallic track extending along the main direction (Z) to a position strictly between the substrate (242) and the working plane (Pt).

公开(公告)号：US11857343B2

公开(公告)日：2024-01-02

申请号：US16463323

申请日：2017-11-28

Applicant: The Regents of the University of California

Inventor： Timothy L. Hanson ,  Philip N. Sabes

IPC: B21F45/00 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1473 ,  A61K41/00 ,  A61N1/05 ,  A61N5/06 ,  B23K101/32 ,  B23K1/00

CPC classification number: A61B5/685 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6868 ,  A61K41/0028 ,  A61N1/0502 ,  A61N1/0529 ,  A61N1/0551 ,  A61N5/0601 ,  B21F45/008 ,  A61B2562/12 ,  A61N2005/0612 ,  A61N2005/0651 ,  B23K1/0008 ,  B23K2101/32

Abstract: Methods are provided for the fabrication of microneedles. Microneedles fabricated according to the herein described methods will generally be constructed of multiple lengths of wire winded together, brazed and further manipulated to include a reversible engagement feature. The subject microneedles may find use in a variety of applications and, among other purposes, the reversible engagement feature of such a microneedle may by employed in implanting an implantable device into a biological tissue. Also provided are methods of inserting an implantable device into a biological tissue having an outer membrane. The subject methods may include ablating a section of the outer membrane and inserting the implantable device through the ablated section of outer membrane, including e.g., where the implantable device is inserted using a microneedle including e.g., those microneedles for which methods of fabrication are provided herein.

公开(公告)号：US20230363713A1

公开(公告)日：2023-11-16

申请号：US17962055

申请日：2022-10-07

Applicant: MAHLA POUDINEH ,  AMIN GHAVAMI NEJAD ,  HANJIA ZHENG ,  FATEMEH KEYVANI

Inventor： MAHLA POUDINEH ,  AMIN GHAVAMI NEJAD ,  HANJIA ZHENG ,  FATEMEH KEYVANI

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/685 ,  A61B5/14514

Abstract: Microneedles for detecting targets are described. The microneedles may be made of a hydrogel and a probe coupled to the hydrogel for generating a measurable signal in the presence of the target. The hydrogel microneedles may be used for in-situ detection of targets, such as biomolecules found in interstitial fluid. Also described are methods or producing hydrogel microneedles, articles and apparatus comprising hydrogel microneedles, and methods and uses of the same. The hydrogel microneedles may be used for biosensing, such as in transdermal patches for detecting biomarkers in a subject. The biosensors may be used for continuous, real-time tracking of targets in-situ, without requiring further reagents or processing steps.

公开(公告)号：US11793437B2

公开(公告)日：2023-10-24

申请号：US16531528

申请日：2019-08-05

Applicant: Modular Bionics Inc.

Inventor： Ian Loren Halpern ,  Mark William Merlo

IPC: A61N1/05 ,  A61B5/24 ,  A61B5/00 ,  A61B5/291

CPC classification number: A61B5/24 ,  A61B5/291 ,  A61B5/685 ,  A61N1/0558 ,  A61B2560/0219 ,  A61B2562/046 ,  A61N1/0502 ,  A61N1/0529 ,  A61N1/0531

Abstract: An implanted neural micro interface device comprises microfilaments of various materials and forms embedded within a body. The microfilaments form interaction sites with surrounding neural tissue at their exit points from the implantable body. The body and filaments are configurable in a multitude of positions to provide increased engagement of a given neural tissue section as well as interaction and closed loop feedback between the microfilament sites. Such configurations allow for a range of recording, stimulating, and treatment modalities for the device within research and clinical settings.

公开(公告)号：US20230172549A1

公开(公告)日：2023-06-08

申请号：US18104460

申请日：2023-02-01

Applicant: Autonomix Medical, Inc.

Inventor： Landy Toth ,  Robert Schwartz

IPC: A61B5/00 ,  A61B18/14 ,  A61N1/05 ,  A61B5/24 ,  A61B5/389 ,  A61B5/11 ,  A61N1/36

CPC classification number: A61B5/6851 ,  A61B18/1492 ,  A61N1/05 ,  A61B5/6852 ,  A61B5/4041 ,  A61B5/24 ,  A61B5/389 ,  A61B5/11 ,  A61B5/4875 ,  A61B5/685 ,  A61N1/36139 ,  A61B2018/0016

Abstract: Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

公开(公告)号：US11668698B2

公开(公告)日：2023-06-06

申请号：US16603092

申请日：2018-04-04

Applicant: Neuraura Biotech Inc.

Inventor： Pierre Jean Jacques Wijdenes ,  Colin Dalton

IPC: G01N33/483 ,  G01N27/00 ,  A61B5/00 ,  A61B5/291

CPC classification number: G01N33/4836 ,  A61B5/685 ,  G01N27/00 ,  A61B5/291 ,  A61B2562/028 ,  A61B2562/046

Abstract: The present disclosure provides a three-dimensional micro-electrode that comprises an electrically conductive, elongate body with: a base that is electrically connectible to a recording system; a tip that is opposite the base and that is configured to establish electrical communication with an excitable cellular-network or a cell therein; and an elongate portion between the base and the tip. The elongate portion is covered with at least one layer of an electrical-insulator coating that extends from the base to proximal the tip. The present disclosure also provides a micro-electrode array comprising at least two three-dimensional micro-electrodes that are electrically connective to at least one recording system. The present disclosure also provides a method of making and using a three-dimensional micro-electrode and an array that comprises three-dimensional micro-electrodes.

公开(公告)号：US20230148914A1

公开(公告)日：2023-05-18

申请号：US17917123

申请日：2021-04-06

Applicant: PKvitality

Inventor： Luc PIERART ,  Anh-Minh LE ,  Kevin Ly HAK

IPC: A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14514 ,  A61B5/685 ,  A61B5/68335 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2562/162

Abstract: The present invention relates to a body monitoring system comprising a patch, the patch comprising a main body, the main body comprising a second face suitable for facing the skin of a user, the patch comprising an adhesive layer at least partially covering the second face, and a peelable cover covering the adhesive layer, the peelable cover comprising at least two separate portions, the portions being adjacent to each other, the main body and the adhesive layer comprise a central portion forming an opening suitable for receiving the capsule, the opening having a maximum diameter greater than 2 mm, preferably greater than 5 mm.