公开(公告)号：US20210345996A1

公开(公告)日：2021-11-11

申请号：US17380258

申请日：2021-07-20

Applicant: RAPHAS CO., LTD.

Inventor： Keun Ho LEE ,  Eun Jin AN ,  Seong Jin KIM ,  Chang Yub SUNG ,  Jung Dong KIM ,  Do Hyeon JEONG ,  Kwang Hoon LEE

IPC: A61B10/02 ,  A61L31/04

Abstract: The present disclosure relates to a minimally-invasive skin biopsy method. The minimally-invasive skin biopsy method according to the present disclosure includes: preparing a microneedle patch; attaching the microneedle patch to a skin of an object; maintaining a state in which the microneedle patch is attached to the skin of the object for a predetermined period of time; and detaching the microneedle patch from the skin of the object after the predetermined period of time, and analyzing a protein component of the object, which adheres to a microneedle of the microneedle patch. The microneedle is made of a biocompatible polymer substance.

公开(公告)号：US20230148950A1

公开(公告)日：2023-05-18

申请号：US17995559

申请日：2020-06-11

Applicant: RAPHAS CO., LTD.

Inventor： Do Hyeon JEONG ,  Jung Dong KIM ,  Keun Ho LEE ,  Kwang Hoon LEE

IPC: A61B5/00 ,  G01N33/68 ,  G01N33/573 ,  A61B10/02

CPC classification number: A61B5/445 ,  A61B5/685 ,  A61B10/02 ,  G01N33/573 ,  G01N33/6869 ,  G01N2333/5406 ,  G01N2333/5437 ,  G01N2800/202

Abstract: A minimally-invasive atopic dermatitis test method comprises the steps of: applying, to the skin of a subject, a microneedle patch including a plurality of microneedles made of a biodegradable hyaluronic acid polymer and having a solid core structure and a bottom layer which is a base on which the plurality of microneedles are formed; maintaining the microneedle patch attached to the skin of the subject for a predetermined time; separating the microneedle patch from the skin of the subject after a predetermined time has passed to input the microneedle patch to a quantitative test; reading the amount of interleukin-4 and interleukin-13 adsorbed onto the surface of the microneedles of the microneedle patch in the quantitative test step; and evaluating atopic dermatitis activity on the basis of the reading of the amount of interleukin-4 and interleukin-13.