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    HUMANIZED UNIVERSAL LIGHT CHAIN MICE
    4.
    发明申请
    HUMANIZED UNIVERSAL LIGHT CHAIN MICE 有权

    公开(公告)号：US20220394959A1

    公开(公告)日：2022-12-15

    申请号：US17734392

    申请日：2022-05-02

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： John McWhirter ,  Lynn Macdonald ,  Sean Stevens ,  Andrew J. Murphy ,  Margaret Karow

    IPC分类号： A01K67/027 ,  C07K16/00 ,  C12N9/64 ,  C12N15/85

    摘要： Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V/J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided.

    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI
    5.
    发明申请
    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI 审中-公开

    公开(公告)号：US20200281175A1

    公开(公告)日：2020-09-10

    申请号：US16849782

    申请日：2020-04-15

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： Lynn Macdonald ,  Sean Stevens ,  Andrew J. Murphy ,  Margaret Karow ,  John McWhirter

    IPC分类号： A01K67/027 ,  C12P21/02 ,  C07K16/46

    摘要： Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

    ADAM6 mice
    6.
    发明授权
    ADAM6 mice 有权

    公开(公告)号：US10577430B2

    公开(公告)日：2020-03-03

    申请号：US16059871

    申请日：2018-08-09

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： Lynn Macdonald ,  Sean Stevens ,  Andrew J. Murphy ,  Margaret Karow

    IPC分类号： C12N5/10 ,  C07K16/40 ,  C07K16/28 ,  C07K16/46 ,  C12N9/64 ,  C12N15/85 ,  B60H1/32 ,  A01K67/027 ,  C07K16/22

    摘要： Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.