公开(公告)号：US20250069684A1

公开(公告)日：2025-02-27

申请号：US18815472

申请日：2024-08-26

Applicant: REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Visweswaran Ravikumar ,  Salar Fattahi ,  Arvind Rao ,  Tong Xu

IPC: G16B5/00 ,  G16B40/30 ,  G16H20/10

Abstract: Systems for inferring spatially-varying regulatory networks, such as gene regulatory networks, are provided. Optimization processes are performed and include regularization minimization processes that rely on one or both of a smoothly-changing minimization process and a sparsely-changing minimization process, for example to learn sparsely- or smoothly-changing Gaussian Markov random fields (GMRF). The systems are further able to convert spatially-varying data, such as spatial transcriptomic data, into spatio-temporal regulatory networks.