专利检索 ap:("REGENTS OF THE UNIVERSITY OF MINNESOTA") AND inv:"Huarui Cui" 第 1 页

1.

发明公开
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20240294503A1

公开(公告)日：2024-09-05

申请号：US18639608

申请日：2024-04-18

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Joseph J. Topczewski , William C.K. Pomerantz , Angela S. Carlson , Huarui Cui , Anand Divakaran

IPC分类号： C07D401/14 , C07D403/14

CPC分类号： C07D401/14 , C07D403/14

摘要： The invention provides a compound of formula I:

or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.

2.

发明授权
Therapeutic compounds and methods of use thereof 有权

公开(公告)号：US11987572B2

公开(公告)日：2024-05-21

申请号：US16892072

申请日：2020-06-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Joseph J. Topczewski , William C. K. Pomerantz , Angela S. Carlson , Huarui Cui , Anand Divakaran

IPC分类号： C07D401/14 , C07D403/14

CPC分类号： C07D401/14 , C07D403/14

摘要： The invention provides a compound of formula I:

or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.

3.

发明公开
SELECTIVE BRD4-DEGRADER MOLECULES 审中-公开

公开(公告)号：US20240051938A1

公开(公告)日：2024-02-15

申请号：US18228422

申请日：2023-07-31

申请人： Regents of the University of Minnesota

发明人： Huarui Cui , Anand Divakaran , Daniel A. Harki , William C. K. Pomerantz

IPC分类号： C07D401/14 , A61P35/00

CPC分类号： C07D401/14 , A61P35/00

摘要： The invention provides a compound of formula (I):

or a salt thereof wherein B, L, and X have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) or a salt thereof. The compounds selectively degrade BRD4, and are useful as to treat cancer and inflammatory conditions.

4.

发明申请
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20200377474A1

公开(公告)日：2020-12-03

申请号：US16892072

申请日：2020-06-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Joseph J. Topczewski , William C.K. Pomerantz , Angela S. Carlson , Huarui Cui , Anand Divakaran

IPC分类号： C07D401/14

摘要： The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.