公开(公告)号：US20170260124A1

公开(公告)日：2017-09-14

申请号：US15605195

申请日：2017-05-25

申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

发明人： Khosrow Kashfi ,  Ravinder Kodela

IPC分类号： C07C203/04 ,  C07F9/6558 ,  C07D413/12 ,  C07D339/04 ,  C07D271/08 ,  C07C331/28 ,  C07C327/48 ,  A61K31/655 ,  C07F9/6578

CPC分类号： C07C203/04 ,  A61K31/655 ,  C07C327/48 ,  C07C331/28 ,  C07D271/08 ,  C07D339/04 ,  C07D413/12 ,  C07F9/65583 ,  C07F9/6578

摘要： This disclosure relates to compounds containing both an NO-releasing moiety and an H2S-releasing moiety and the use of such compounds in treating inflammatory diseases, including cancers.

公开(公告)号：US10023555B2

公开(公告)日：2018-07-17

申请号：US14766258

申请日：2014-02-07

申请人： Research Foundation of The City University of New York

发明人： Khosrow Kashfi ,  Mitali Chattopadhyay ,  Ravinder Kodela

IPC分类号： C07F9/09 ,  C07F9/6574 ,  C07D339/04 ,  C07F9/6553

摘要： The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof.

公开(公告)号：US20150376162A1

公开(公告)日：2015-12-31

申请号：US14766258

申请日：2014-02-07

申请人： THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

发明人： Khosrow Kashfi ,  Mitali Chattopadhyay ,  Ravinder Kodela

IPC分类号： C07D339/04 ,  C07F9/09

CPC分类号： C07D339/04 ,  C07F9/09 ,  C07F9/091 ,  C07F9/655345 ,  C07F9/65742

摘要： The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof.

摘要翻译： 本发明公开了衍生自NSAIDs的新化合物及其药学上可接受的盐。 本发明的其它方面涉及NSAID衍生物在治疗炎性疾病中的应用及其药物组合物。

公开(公告)号：US10450260B2

公开(公告)日：2019-10-22

申请号：US15605195

申请日：2017-05-25

申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

发明人： Khosrow Kashfi ,  Ravinder Kodela

IPC分类号： A61K31/60 ,  C07C203/04 ,  A61K31/655 ,  C07C327/48 ,  C07C331/28 ,  C07D271/08 ,  C07D339/04 ,  C07D413/12 ,  C07F9/6558 ,  C07F9/6578

摘要： This disclosure relates to compounds containing both an NO-releasing moiety and an H2S-releasing moiety and the use of such compounds in treating inflammatory diseases, including cancers.

公开(公告)号：US10071981B2

公开(公告)日：2018-09-11

申请号：US15115959

申请日：2015-02-11

申请人： Research Foundation of The City University of New York ,  Cyprus University of Technology

发明人： Khosrow Kashfi ,  Vasileios Fotopoulos

IPC分类号： C07D339/04 ,  A01N43/26

CPC分类号： C07D339/04 ,  A01N33/20 ,  A01N43/26 ,  A01N59/00 ,  A61K31/24 ,  A61K31/385 ,  A61K31/621 ,  A61K31/625 ,  A01N59/02

摘要： A method of reducing cellular damage to a plant by treating the plant with a compound containing an NO-releasing moiety and an H2S-releasing moiety covalently bonded to an aspirin derived core or a NOSH compound is claimed. The compounds may also be used in a method of priming a plant against abiotic stress factors and a method of promoting plant growth.

公开(公告)号：US20170174651A1

公开(公告)日：2017-06-22

申请号：US15115959

申请日：2015-02-11

申请人： Research Foundation of the City University of New York ,  Cyprus University of Technology

发明人： Khosrow Kashfi ,  Vasileios Fotopoulos

IPC分类号： C07D339/04 ,  A01N43/26

CPC分类号： C07D339/04 ,  A01N33/20 ,  A01N43/26 ,  A01N59/00 ,  A61K31/24 ,  A61K31/385 ,  A61K31/621 ,  A61K31/625 ,  A01N59/02

摘要： A method of reducing cellular damage to a plant by treating the plant with a compound containing an NO-releasing moiety and an H2S-releasing moiety covalently bonded to an aspirin derived core or a NOSH compound is claimed. The compounds may also be used in a method of priming a plant against abiotic stress factors and a method of promoting plant growth.