公开(公告)号：US20230330205A1

公开(公告)日：2023-10-19

申请号：US18163855

申请日：2023-02-02

申请人： RESILIENCE GOVERNMENT SERVICES, INC.

发明人： Ron COBB ,  Michael SPRINGER ,  Yawei NI

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/295 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19

CPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/295 ,  A61K9/0095 ,  A61K9/1694 ,  A61K9/19 ,  A61K2039/5258 ,  A61K2039/55583 ,  C12N2770/16034 ,  A61K2039/541 ,  A61K2039/70 ,  C12N2770/16023 ,  C12N2770/16071

摘要： A dry powder Norovirus vaccine is provided, which comprises at least two Norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against Norovirus infections.