公开(公告)号：US20240269267A1

公开(公告)日：2024-08-15

申请号：US18566859

申请日：2022-06-03

申请人： The Wistar Institute of Anatomy and Biology

发明人： David Weiner ,  Pratik Bhojnagarwala ,  Ebony Gary

IPC分类号： A61K39/295 ,  A61K39/00 ,  A61P31/16 ,  A61P31/22

CPC分类号： A61K39/295 ,  A61P31/16 ,  A61P31/22 ,  A61K2039/53 ,  A61K2039/572 ,  C12N2710/16134 ,  C12N2710/16634 ,  C12N2730/10134 ,  C12N2740/13034 ,  C12N2760/16134 ,  C12N2760/18534 ,  C12N2760/20234 ,  C12N2770/24234

摘要： Disclosed herein is a composition comprising one or more viral antigen or a recombinant nucleic acid sequence that encodes one or more viral antigen with enhanced immunogenicity in vivo. Also disclosed herein is a method of generating an immune response in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a viral infection in a subject using said composition and methods.

公开(公告)号：US20240226283A9

公开(公告)日：2024-07-11

申请号：US18032052

申请日：2021-10-15

申请人： CITY OF HOPE

发明人： Don J. DIAMOND ,  Corinna LA ROSA

IPC分类号： A61K39/245 ,  A61K39/295 ,  C12N15/86

CPC分类号： A61K39/245 ,  A61K39/295 ,  C12N15/86 ,  A61K2039/5256

摘要： Disclosed is a method of treating or preventing a CMV infection in a recipient of a hematopoietic cell transplant (HCT). The method entails administering an effective amount of a CMV Triplex vaccine composition to a donor and/or recipient of the hematopoietic cells.

公开(公告)号：US20240197865A1

公开(公告)日：2024-06-20

申请号：US18556668

申请日：2022-04-22

申请人： University of Saskatchewan

发明人： Sylvia Van Den Hurk ,  Volker Gerdts ,  Robert Brownlie ,  Ravendra Garg

IPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/005

CPC分类号： A61K39/295 ,  A61K39/39 ,  A61P37/04 ,  C07K14/005 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6018 ,  A61K2039/70 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18622 ,  C12N2760/18634

摘要： The present invention provides immunogenic chimeric respiratory syncytial virus (RSV)-parainfluenza virus type 3 (PIV3) compounds and associated compositions, along with methods of treating, preventing and/or diagnosing RSV- and PIV3-related disorders.

公开(公告)号：US20240197864A1

公开(公告)日：2024-06-20

申请号：US18278682

申请日：2022-02-24

申请人： MIGVAX LTD.

发明人： Sigal KREMER-TAL ,  Morris LASTER ,  Jacob PITCOVSKI

IPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/108 ,  A61K39/215 ,  A61P31/14

CPC分类号： A61K39/295 ,  A61K39/0258 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/645 ,  C12N2770/20034

摘要： The present invention is directed to a method for increasing immunization efficiency of a subject to a pathogen, including administering a therapeutically effective amount of a pharmaceutical composition including: (a) a heat labile toxin subunit B (LTB) polypeptide or a functional analog thereof, and (b) an immunogenic polypeptide derived from the pathogen.

公开(公告)号：US20240130973A1

公开(公告)日：2024-04-25

申请号：US18372556

申请日：2023-09-24

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Theodore Randolph ,  Robert Garcea

IPC分类号： A61K9/19 ,  A61K9/16 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00

CPC分类号： A61K9/19 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00 ,  A61K2039/5258

摘要： Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US11945842B2

公开(公告)日：2024-04-02

申请号：US17077206

申请日：2020-10-22

申请人： International Centre for Genetic Engineering and Biotechnology

发明人： Navin Khanna ,  Viswanathan Ramasamy

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/295 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/295 ,  C12N7/00 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/70 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2730/10151 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/30

摘要： The invention provides a recombinant polypeptide comprising the EDIII domain of each of Dengue virus serotype DENV-1, DENV-2, DENV-3, and DENV-4 linked to the N-terminal of HBsAg.

公开(公告)号：US11938181B2

公开(公告)日：2024-03-26

申请号：US17371555

申请日：2021-07-09

申请人： nference, Inc.

发明人： Colin Pawlowski ,  Venkataramanan Soundararajan ,  Arjun Puranik ,  Murali Aravamudan

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/09 ,  A61K39/116 ,  A61K39/145 ,  A61K39/25 ,  A61K39/29 ,  A61K39/295 ,  A61P31/14 ,  A61P37/04

CPC分类号： A61K39/215 ,  A61K39/092 ,  A61K39/116 ,  A61K39/145 ,  A61K39/25 ,  A61K39/29 ,  A61K39/292 ,  A61K39/295 ,  A61P31/14 ,  A61P37/04 ,  A61K2039/55

摘要： This application relates to methods for assessing patient populations and determining subpopulations vulnerable to viral infection, methods of reducing the risk of infection and/or inducing heterologous immunity to said viral infection.

公开(公告)号：US11858964B2

公开(公告)日：2024-01-02

申请号：US17505466

申请日：2021-10-19

申请人： VerImmune Inc.

发明人： Joshua Weiyuan Wang ,  Ken Matsui ,  Philip Alan Storm ,  Kristin Marie Peters

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/295 ,  A61K39/155 ,  C07K14/005 ,  C12N7/00 ,  A61P35/00

CPC分类号： C07K14/005 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/295 ,  A61P35/00 ,  C12N7/00 ,  A61K2039/585 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/70 ,  C07K2319/50 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/20052

摘要： Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

公开(公告)号：US20230293662A1

公开(公告)日：2023-09-21

申请号：US18069058

申请日：2022-12-20

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC分类号： A61K39/12 ,  A61K39/295 ,  A61K45/06

CPC分类号： A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252

摘要： Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US11738077B2

公开(公告)日：2023-08-29

申请号：US17068173

申请日：2020-10-12

申请人： Boehringer Ingelheim Animal Health USA Inc.

发明人： Jeremy Kroll ,  Mike Roof

IPC分类号： A61K39/02 ,  A61K39/112 ,  A61K39/12 ,  C12N7/00 ,  A61K39/39 ,  A61K35/74 ,  A61K39/295 ,  A61K39/00

CPC分类号： A61K39/105 ,  A61K39/0241 ,  A61K39/0275 ,  A61K39/12 ,  C12N7/00 ,  A61K35/74 ,  A61K39/295 ,  A61K39/39 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/525 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2750/10034 ,  Y02A50/30 ,  Y10S424/825

摘要： The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.