公开(公告)号：US3818056A

公开(公告)日：1974-06-18

申请号：US25921872

申请日：1972-06-02

Applicant: ROUSSEL UCLAF

Inventor： PIERDET A ,  BONNE C

IPC: A61K31/565 ,  C07C20060101 ,  C07J1/00 ,  C07C169/08

CPC classification number: C07J1/007 ,  C07J1/0096

Abstract: WHEREIN R is alkyl having one to three carbon atoms, X represents a member selected from the group consisting of hydrogen, aliphatic hydrocarbon having one to six carbon atoms, halogenated aliphatic hydrocarbon having one to six carbon atoms, and cycloalkyl having three to six carbon atoms, Y is alkyl having one to six carbon atoms, Z represents a member selected from the group consisting of hydrogen, alkyl having one to six carbon atoms and phenyl alkyl having seven to nine carbon atoms, and R'' represents a member selected from the group consisting of hydrogen and the acyl of an organic carboxylic acid having from one to 18 carbon atoms; as well as a process for preparing the compounds, therapeutic compositions and methods. The 11 Alpha alkoxylated steroids possess anti-estrogenic, anti-gonadotrophic and exogenic anti-androgenic activity.

11 Alpha -ALKOXYLATED STEROIDS HAVING THE FORMULA

Abstract translation: 11具有式的α-羟基化甾族化合物R是具有1至3个碳原子的烷基，X表示选自氢，具有1-6个碳原子的脂族烃，具有1-6个碳原子的卤代脂族烃， 和具有3至6个碳原子的环烷基，Y是具有1至6个碳原子的烷基，Z表示选自氢，具有1至6个碳原子的烷基和具有7至9个碳原子的苯基烷基的成员，R “表示选自氢和具有1至18个碳原子的有机羧酸的酰基的成员; 以及制备化合物的方法，治疗组合物和方法。 11种α-烷氧基化甾族化合物具有抗雌激素，抗促性腺激素和外源性抗雄激素活性。