公开(公告)号：US3923800A

公开(公告)日：1975-12-02

申请号：US53963975

申请日：1975-01-09

Applicant: ROUSSEL UCLAF

Inventor： DERIBLE PIERRE HENRI ,  LAVAUX JEAN-PAUL ,  LAURENT JACQUES

IPC: A61K31/54 ,  C07D401/04 ,  C07D417/14 ,  C07D209/14

CPC classification number: C07D417/14 ,  A61K31/54

Abstract: Novel phenothiazines of the formula

WHEREIN X is selected from the group consisting of hydrogen, chlorine, trifluoromethyl, methylthio and methoxy, B is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, p is 0 or 1, R is selected from the group consisting of hydrogen and alkoxy of 1 to 3 carbon atoms and R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic activity and frequently antihistaminic activity and their preparation.

Abstract translation: 式WHEREIN X的新型吩噻嗪由氢，氯，三氟甲基，甲硫基和甲氧基组成的组中选择，B选自氢和1至3个碳原子的烷基，p为0或1，R为 选自氢和1至3个碳原子的烷氧基，R 1和R 2分别选自氢和1至3个碳原子的烷基及其无毒的药学上可接受的具有精神抑制活性的酸加成盐 并经常抗组胺活性及其制备。