公开(公告)号：US3923800A

公开(公告)日：1975-12-02

申请号：US53963975

申请日：1975-01-09

Applicant: ROUSSEL UCLAF

Inventor： DERIBLE PIERRE HENRI ,  LAVAUX JEAN-PAUL ,  LAURENT JACQUES

IPC: A61K31/54 ,  C07D401/04 ,  C07D417/14 ,  C07D209/14

CPC classification number: C07D417/14 ,  A61K31/54

Abstract: Novel phenothiazines of the formula

WHEREIN X is selected from the group consisting of hydrogen, chlorine, trifluoromethyl, methylthio and methoxy, B is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, p is 0 or 1, R is selected from the group consisting of hydrogen and alkoxy of 1 to 3 carbon atoms and R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic activity and frequently antihistaminic activity and their preparation.

Abstract translation: 式WHEREIN X的新型吩噻嗪由氢，氯，三氟甲基，甲硫基和甲氧基组成的组中选择，B选自氢和1至3个碳原子的烷基，p为0或1，R为 选自氢和1至3个碳原子的烷氧基，R 1和R 2分别选自氢和1至3个碳原子的烷基及其无毒的药学上可接受的具有精神抑制活性的酸加成盐 并经常抗组胺活性及其制备。

公开(公告)号：US3891636A

公开(公告)日：1975-06-24

申请号：US40799573

申请日：1973-10-19

Applicant: ROUSSEL UCLAF

Inventor： DERIBLE PIERRE HENRI ,  LAVAUX JEAN-PAUL

IPC: C07D417/06 ,  C07D279/26 ,  C07D279/28

CPC classification number: C07D417/06

Abstract: WHEREIN X is selected from the group consisting of hydrogen, chlorine, -CF3, -OCH3 and SCH3, B and R are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z'' is selected from the group consisting of hydrogen and alkyl of 1 to 10 carbon atoms, p is 0 or 1, n is 0, 1 or 2 and A is selected from the group consisting of hydrogen, -COOR2 and COR1, R2 is linear alkyl of 1 to 15 carbon atoms and R1 is selected from the group consisting of alkyl of 1 to 18 carbon atoms optionally containing a double bond or -0- and a polymethoxyphenyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, analgesic, spasmolytic and antihistaminic activity and their preparation and novel intermediates.
Novel 10-(piperidino-alkyl)-phenothiazines of the formula

Abstract translation: 式WHEREIN X的新颖的10-（哌啶子基 - 烷基） - 吩噻嗪选自氢，氯，-CF 3，-OCH 3和SCH 3，B和R各自独立地选自氢和烷基的1 至4个碳原子，Z'选自氢和1至10个碳原子的烷基，p为0或1，n为0,1或2，A选自氢，-COOR 2 和-COR 1，R 2是1至15个碳原子的直链烷基，并且R 1选自任选含有双键的碳原子数1〜18的烷基或-O-和多甲氧基苯基及其无毒的药学上可接受的 具有止痛，止痛，解痉和抗组胺活性的酸加成盐及其制备和新型中间体。