公开(公告)号：US3910922A

公开(公告)日：1975-10-07

申请号：US83014869

申请日：1969-06-03

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: A61K31/47 ,  C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  F24F3/04 ,  C07D215/14

CPC classification number: A61K31/47 ,  C07D215/18 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: 7- OR 8-TRIFLUOROMETHYL-QUINOLINES OF THE FORMULA

WHEREIN N IS 1 OR 2 AND R is selected from the group consisting of saturated and unsaturated heterocyclic having an oxygen atom, a nitrogen atom or both a nitrogen and oxygen atom and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract translation: 7-或8-三氟甲基喹啉，其中N为1或2，R选自具有氧原子，氮原子或氮原子和氧原子的饱和和不饱和杂环及其无毒性 ，具有镇痛和抗炎活性的药学上可接受的酸加成盐及其制备。

公开(公告)号：US3910898A

公开(公告)日：1975-10-07

申请号：US45760474

申请日：1974-04-03

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: A61K31/47 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  F24F3/04 ,  C07D295/04

CPC classification number: A61K31/47 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: 7- OR 8-TRIFLUOROMETHYL-QUINOLINES OF THE FORMULA

WHEREIN N IS 1 OR 2 AND R is morpholino and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract translation: 7-或8-三氟甲基喹啉，其中N为1或2，R为吗啉代及其无毒，药学上可接受的具有镇痛和抗炎活性的酸加成盐及其制备方法。

公开(公告)号：US3892773A

公开(公告)日：1975-07-01

申请号：US36217273

申请日：1973-05-21

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN ,  DUBE JACQUES

IPC: C07D335/02 ,  C07D309/06 ,  C07D65/04 ,  C07D7/04

CPC classification number: C07D309/06

Abstract: Novel 2-phenyl ethanol derivatives of the formula

WHEREIN X is selected from the group consisting of oxygen and sulfur, Hal is halogen, R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and Y is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and when R is alkyl, they exist in the form of racemates or optically active isomers having analgesic and anti-inflammatory activity.

Abstract translation: 式WHEREIN X的新型2-苯基乙醇衍生物选自氧和硫，Hal是卤素，R选自氢和1至4个碳原子的烷基，Y选自 由氢和1至18个碳原子的有机羧酸的酰基组成，当R是烷基时，它们以具有止痛和消炎活性的外消旋物或旋光异构体的形式存在。

公开(公告)号：US3644368A

公开(公告)日：1972-02-22

申请号：US78639868

申请日：1968-12-23

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/44 ,  C07D33/52

CPC classification number: C07D215/233 ,  C07D215/18 ,  C07D215/44

Abstract: NOVLE 4 - (ORTHOR-(2'',3''-DIHYDROXYPROPYLOXYCARBONYL)PHENYL)-AMINO-QUINOLINES OF THE FORMULA

4-((2-(R''-O-CH2-CH(-O-R)-CH2-OOC-)PHENYL)-NH-),CF3-

QUINOLINE

WHEREIN THE CF3 RADICAL IS IN THE 7 OR 8-POSITION, R AND R'' ARE HYDROGEN AND TAKEN TOGETHER FORM A KETONIDE OF THE FORMULA

-C(-P)(-Q)-

P AND O BEING SELECTED FROM THE GROUP COSISTING OF ALKYL ARALKYL AND ARYL AND THE NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS WHEN R AND R'' ARE HYDROGEN'', WHICH POSSESS NOTABLE ANTI-INFLAMMATORY ACTIVITY AND INTENSE ANALGESIC ACTIVITY.

Abstract translation: 下式的新型4- [邻 - （2'，3'-二羟基丙氧基羰基） - 苯基] - 氨基 - 喹啉CF 3基团在七或八位，R和R'是氢并且一起形成酮 当R和R'是氢时，式P和Q选自烷基芳烷基和芳基以及无毒的药学上可接受的加成盐，其具有显着的抗炎活性和强烈的镇痛活性。

公开(公告)号：US3502681A

公开(公告)日：1970-03-24

申请号：US3502681D

申请日：1968-04-10

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRO ,  MEIER JEAN

IPC: C07D215/44 ,  C07D33/52

CPC classification number: C07D215/44