公开(公告)号：US3679802A

公开(公告)日：1972-07-25

申请号：US3679802D

申请日：1970-10-07

Applicant: ROUSSEL UCLAF

Inventor： RATOUIS ROGER ,  BOISSIER JACQUES ROBERT

IPC: C07D307/87 ,  A61K27/00

CPC classification number: C07D307/87

Abstract: Novel anticonvulsant composition containing as the active ingredient, 3,3-dimethyl-1-phenyl-1-acetamidophthalanne of the formula

AND TO A NOVEL METHOD OF PREVENTING CONVULSIONS IN WARM-BLOODED ANIMALS.

Abstract translation: 含有下式的3,3-二甲基-1-苯基-1-乙酰氨基邻苯二甲酸盐作为活性成分的新型抗惊厥药组合物，以及一种防止温血动物炎症反应的新方法。

公开(公告)号：US3635983A

公开(公告)日：1972-01-18

申请号：US3635983D

申请日：1967-12-07

Applicant: ROUSSEL UCLAF

Inventor： BOISSIER JACQUES R ,  RATOUIS ROGER

IPC: A61K31/00 ,  C07D55/54

CPC classification number: A61K31/00 ,  Y10S514/91 ,  Y10S514/96

Abstract: THE COMPOUNDS ARE DERIVATIVES OF 11H-DIBENZO(1,2,5) TRIAZEPINE AND THEIR ACID ADDITION AND QUATERNARY AMMONIUM SALTS; THEY CORRESPOND TO THE FORMULA:

11-(R1-N(-R2)-A-)-11H-DIBENZO(1,2,5)TRIAZEPINE

A: AN ALKYLENE RADICAL CONTAINING FROM 2 TO 4 CARBON ATOMS. R1-R2: LOWER ALKYL OR HYDROXYALKYL RADICALS, OR FORM WITH THE NITROGEN ATOM N TO WHICH THEY ARE BOUND A HETEROCYCLIC EVENTUALLY SUBSTITUTED BY ONE OR SEVERAL LOWER ALKYL OR HYDROXYALKYL RADICALS. THEY ARE VERY USEFUL SUBSTANCES AS THERAPEUTICS, NAMELY, AS THYMOANALEPTICS, ANTIPARKINSONIANS, ANORECTICS, LOCAL ANESTHETICS AND ANTIHISTAMINICS. THE COMPOUNDS OF FORMULA 1 ARE PREPARED BY REACTING, IN THE PRESENCE OF AN ALKALINE AGENT, 11H-DIBENZO(1,2,5) TRIAZEPINE OF FORMULA:

11H-DIBENZO(1,2,5)TRIAZEPINE

WITH A COMPOUND OF FORMULA:

X-A-N(-R1)-R2

(X: HALOGEN ATOM).

公开(公告)号：US3697590A

公开(公告)日：1972-10-10

申请号：US3697590D

申请日：1969-07-28

Applicant: ROUSSEL UCLAF

Inventor： BOISSIER JACQUES R ,  RATOUIS ROGER

IPC: A61K31/19 ,  C07C101/44

CPC classification number: A61K31/19 ,  Y10S514/916

Abstract: WHERE R represents an hydrogen or a methyl radical. Compounds of formula (1) and their metallic and amine salts are very useful substances in human therapeutics, namely as analgesic, antipyretic and antiinflamatory medicines. Compounds of formula (1) are prepared by reacting a 2phenothiazinylacetic acid of formula:

Phenylacetic acid derivatives having the formula:
WITH A DESULFURIZING REDUCING AGENT.

D R A W I N G

公开(公告)号：US3651049A

公开(公告)日：1972-03-21

申请号：US3651049D

申请日：1970-03-12

Applicant: ROUSSEL UCLAF

Inventor： BOISSIER JACQUES R ,  RATOUIS ROGER

IPC: A61K31/573 ,  A61K31/58 ,  C07D319/08 ,  C07J21/00 ,  C07C173/00

CPC classification number: A61K31/573 ,  A61K31/58 ,  C07D319/08 ,  C07J21/00

Abstract: CYCLIC ACETAL DERIVATIVES OF PREGNANE OF GENERAL FORMULA:

3,5''-DI(O=),6-Z,9-Y,16-P,2''-(R1-CH=C(-R)-(CH2)N-)SPIRO

(ANDROSTA-1,4-DIENE-17,4''-(1,3)DIOXANE) WITH X IN

POSITION 11

WHEREIN X:CO OR CH2 OR CHOH-Y:H OR F-Z:H OR CH3-P:H OR ALKYL OR ALKYIDENE-N: O OR 1-R:H OR HALOGEN OR ALKYL-R1:H OR ALKYL OR CARBOXYL OR ALKOXYCARBONYL-BROKEN LINE IN THE RING A: OPTIONAL PRESENCE OF A DOUBLE BOND. THESE PRODUCTS ARE VERY USEFUL SUBSTANCES IN HUMAN AND ANIMAL THERAPY, ESPECIALLY OWING TO THEIR REMARKABLE ANTI-INFLAMMATORY ACTION. THE PRODUCTS ARE PREPARED BY ACTION OF A DIALKYL ACETAL ON A PREGNANE DERIVATIVE HAVING HYDROXYL RADICALS IN ITS 17 AND 21 POSITIONS, IN THE PRESENCE OF AN ACID CATALYST.

公开(公告)号：US3674841A

公开(公告)日：1972-07-04

申请号：US3674841D

申请日：1969-03-03

Applicant: ROUSSEL UCLAF

Inventor： BOISSIER JACQUES ROBERT ,  RATOUIS ROGER

IPC: C07C91/02 ,  C07C97/10

CPC classification number: C07C215/30

Abstract: The products are new tricyclic amino compounds and acid addition salts thereof, said tricyclic amino compounds corresponding to the general formula : WHERE X represents one of the following divalent hydrocarbon radicals : A represents a carbonyl (CO) or a hydroxymethylene (CHOH) group and R represents a monoalkylamino or a dialkylamino radical. They are very useful substances for human therapeutics, namely as antidepressants and antianxiety agents. The process for preparing compounds of formula (1) and their salts is disclosed.

Abstract translation: 产物是新的三环氨基化合物及其酸加成盐，所述三环氨基化合物对应于通式：