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43 条记录 (耗时 0.013 秒)

    Optically active N-substituted phenylalaninols and use thereof
    1.
    发明授权
    Optically active N-substituted phenylalaninols and use thereof 失效
    光学活性N-取代苯丙氨醇及其用途

    公开(公告)号：US4536601A

    公开(公告)日：1985-08-20

    申请号：US535284

    申请日：1983-09-23

    申请人： Masatoshi Tukamoto ,  Tadahiro Sawayama

    发明人： Masatoshi Tukamoto ,  Tadahiro Sawayama

    IPC分类号： C07B57/00 ,  C07C327/22 ,  C07D317/58 ,  C07C91/02 ,  C07D317/44

    CPC分类号： C07D317/58 ,  C07C327/00

    摘要： Optically active N-substituted phenylalaninols of the formula (I): ##STR1## wherein R is isopropyl, 1-ethylpropyl, cyclopentyl, cyclohexyl, cycloheptyl, 4-methylbenzyl, 4-methoxybenzyl, or 3,4-methylenedioxybenzyl; and acid addition salts thereof which are useful as a resolving agent, and a process for preparing D-3-acetylthio-2-methylpropionic acid which comprises reacting DL-3-acetylthio-2-methylpropionic acid with an optically active N-substituted phenylalaninol of the formula (I) to form diastereomeric salts, subjecting the formed diastereomeric salts to a fractional crystallization from a solvent to separate the D-acid salt from the L-acid salt, and then decomposing the D-acid salt with a mineral acid to give D-3-acetylthio-2-methylpropionic acid.

    摘要翻译： 式（I）的光学活性N-取代苯丙氨醇：其中R是异丙基，1-乙基丙基，环戊基，环己基，环庚基，4-甲基苄基，4-甲氧基苄基或3,4-亚甲二氧基苄基; 可用作拆分剂的其酸加成盐，以及制备D-3-乙酰硫基-2-甲基丙酸的方法，其包括将DL-3-乙酰硫基-2-甲基丙酸与光学活性N-取代苯丙氨醇 式（I）形成非对映异构盐，使形成的非对映体盐从溶剂中分级结晶，从D-酸盐与L-酸盐分离，然后用无机酸分解D-酸盐，得到 D-3-乙酰硫基-2-甲基丙酸。

    Amines via the amination of olefins
    2.
    发明授权
    Amines via the amination of olefins 失效
    胺通过烯烃的胺化

    公开(公告)号：US4375002A

    公开(公告)日：1983-02-22

    申请号：US248403

    申请日：1981-04-08

    申请人： John O. H. Peterson ,  Howard S. Fales

    发明人： John O. H. Peterson ,  Howard S. Fales

    IPC分类号： C07C209/00 ,  C07C209/60 ,  C07C211/21 ,  C07C91/02

    CPC分类号： C07C209/60

    摘要： This invention relates to an improvement in the vapor phase catalytic production of an amine by the reaction of a mixture comprising an olefin having from 2 to 8 carbon atoms and ammonia or ammonia type compound. The improvement which provides for high selectivity to the amine resides in the use of an alumino silicate as the catalyst.

    摘要翻译： 本发明涉及通过包含2至8个碳原子的烯烃与氨或氨型化合物的混合物的反应来改进胺的气相催化反应。 提供对胺的高选择性的改进在于使用铝硅酸盐作为催化剂。

    N-2,3-Dihydroxypropyl-N-2-hydroxyalkyl-amine and its salts
    4.
    发明授权
    N-2,3-Dihydroxypropyl-N-2-hydroxyalkyl-amine and its salts 失效
    N-2,3-二羟基丙基-N-2-羟烷基 - 胺及其盐

    公开(公告)号：US4083872A

    公开(公告)日：1978-04-11

    申请号：US653835

    申请日：1976-01-30

    申请人： Werner Schwarze ,  Wolfgang Merk ,  Volker Binder

    发明人： Werner Schwarze ,  Wolfgang Merk ,  Volker Binder

    IPC分类号： C08K5/00 ,  C07C67/00 ,  C07C213/00 ,  C07C215/12 ,  C07C215/28 ,  C07C215/40 ,  C08K5/17 ,  C08K5/19 ,  C08L1/00 ,  C08L23/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/02 ,  C08L101/00 ,  C09K3/16 ,  C07C91/02 ,  C07C87/29 ,  C07C87/30 ,  C07C91/06

    CPC分类号： C08K5/17 ,  C08K5/19 ,  Y10S524/912 ,  Y10S524/913

    摘要： There are prepared compounds of the formulae ##STR1## where R and R.sup.1 are saturated alkyl groups in which the sum of the carbon atoms in the two alkyl groups is 4 to 30 carbon atoms and wherein one of R and R.sup.1 can be hydrogen,R.sup.2 is hydrogen, lower alkyl with one to five carbon atoms, 2-hydroxyethyl, 2-hydroxypropyl, 2,3-dihydroxypropyl, benzyl,o-,m- or p-methylbenzyl, o-,m- or p-chlorobenzyl, o-,m- or p-bromobenzyl, aminoalkyl (C.sub.2 to C.sub.6), preferably aminoalkyl (C.sub.2 and C.sub.3), alkyl (C.sub.1 to C.sub.5)-aminoalkyl (C.sub.2 to C.sub.6), 2-hydroxyethyl-aminoalkyl (C.sub.2 to C.sub.6), 2-hydroxypropyl-aminoalkyl (C.sub.2 to C.sub.6) or 2,3-dihydroxy-propyl-aminoalkyl (C.sub.2 to C.sub.6),R.sup.3 in case the compound is present as the ammonium salt is hydrogen or a lower alkyl group with 1 to 5 carbon atoms, andX- is a monovalent, inorganic or organic acid group or one equivalent of a polybasic inorganic or organic group.The compounds are useful as antistatic finishing agents for thermoplastic synthetic resins.

    摘要翻译： 制备式Ⅰ和Ⅱ的化合物，其中R和R 1为饱和烷基，其中两个烷基中的碳原子总数为4至30个碳原子，其中R和R 1中的一个 可以是氢，R2是氢，具有1-5个碳原子的低级烷基，2-羟乙基，2-羟丙基，2,3-二羟丙基，苄基，邻 - ，对 - 甲基苄基，邻 - ，间 - 或对 - （C2至C6），优选氨基烷基（C2和C3），烷基（C1至C5） - 氨基烷基（C2至C6），2-羟基乙基 - 氨基烷基（C2至C6烷基） C6），2-羟丙基 - 氨基烷基（C2-C6）或2,3-二羟基 - 丙基 - 氨基烷基（C2-C6），当化合物作为铵盐存在时，R3是氢或低级烷基， 5个碳原子，X-是一价无机或有机酸基团或一当量的多元无机或有机基团。

    Phosphate salts of amine based polyols
    5.
    发明授权
    Phosphate salts of amine based polyols 失效
    胺基多元醇的磷酸盐

    公开(公告)号：US3890389A

    公开(公告)日：1975-06-17

    申请号：US33536973

    申请日：1973-02-23

    申请人： ICI AMERICA INC

    发明人： FOWLER RAYMOND H

    IPC分类号： C08G18/08 ,  C08G18/38 ,  C08G18/50 ,  C07C91/02

    CPC分类号： C08G18/5075 ,  C08G18/0814 ,  C08G18/3878 ,  C08G2101/0025 ,  C08G2101/005

    摘要： Disclosed is the phosphate salt of amine based polyols which are useful in preparing low density polyurethane foams. The phosphate salt of amine based polyols includes those compositions prepared by reacting alkoxylated mono- and/or polyamines with phosphoric acid. Rigid low density polyurethane foams are prepared from a polyol blend of a phosphate salt of an amine based polyol and one or more other polyhydroxy compounds.

    摘要翻译： 公开了可用于制备低密度聚氨酯泡沫的胺基多元醇的磷酸盐。 胺基多元醇的磷酸盐包括通过烷氧基化单 - 和/或多胺与磷酸反应制备的那些组合物。 刚性低密度聚氨酯泡沫由胺基多元醇的磷酸盐和一种或多种其它多羟基化合物的多元醇共混物制备。

    N-(1-hydroxy-1-phenyl-ethyl amino)-propiophenones
    6.
    发明授权
    N-(1-hydroxy-1-phenyl-ethyl amino)-propiophenones 失效
    N-（1-羟基-1-苯基 - 乙基氨基） - 丙烯酸

    公开(公告)号：US3646145A

    公开(公告)日：1972-02-29

    申请号：US3646145D

    申请日：1968-07-01

    申请人： DEGUSSA

    发明人： THIELE KURT

    IPC分类号： A61K31/135 ,  A61K31/137 ,  C07C67/00 ,  C07C213/00 ,  C07C225/16 ,  C07C229/38 ,  C07C91/02

    CPC分类号： C07C229/38

    摘要： COMPOUNDS OF THE FORMULA

    R1,R2,R3,((R8,R9-PHENYL)-CH(-R7)-CH(-R6)-N(-R5)-CH2-

    CH(-R4)-CO-)BENZENE

    IN WHICH:

    R1 IS FLUORINE, -CN, -COOH, -COOALK, WHEREIN ALK IS LOWER ALKYL, LOWER ALKYL MERCAPTO OR LOWER ALKYL SULFONYL; R2 AND R3 ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, CHLORINE, BROMINE, LOWER ALKYL, LOWER ALKOXY AND HYDROXY; R4 IS HYDROGEN, METHYL OR ETHYL; R5 IS HYDROGEN OR LOWER ALKYL; R6 IS HYDROGEN OR LOWER ALKYL; R7 IS HYDROGEN OR HYDROXY AND R8 AND R9 ARE HYDROGEN, HALOGEN, LOWER ALKYL, LOWER ALKOXY OR HYDROXY AND THEIR PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION AND QUATERNARY AMMONIUM SALTS WHICH HAVE HEART ACTIVITY, PARTICULARLY IN INCREASING CORONARY BLOOD FLOW AND CONTRACTION AMPLITUDE.

    Process for manufacturing 2-aminobutanol
    8.
    发明授权
    Process for manufacturing 2-aminobutanol 失效
    2-氨基丁醇的制备方法

    公开(公告)号：US3953512A

    公开(公告)日：1976-04-27

    申请号：US452372

    申请日：1974-03-18

    申请人： Czeslaw Belzecki ,  Witold Tomasik ,  Jerzy Trojnar

    发明人： Czeslaw Belzecki ,  Witold Tomasik ,  Jerzy Trojnar

    IPC分类号： C07C67/00 ,  C07C213/00 ,  C07C213/04 ,  C07C215/08 ,  C07D203/08 ,  C07C91/02 ,  C07C93/02 ,  C07C93/10 ,  C07C95/02

    CPC分类号： C07D203/08

    摘要： The invention relates to a method of preparation of 2-aminobutanol from readily available raw materials. The method of this invention is based on the reaction between 1.2-epoxybutane or isomeric butylene halogenehydrines with ammonia. The product, isomeric aminobutanols, are, subsequently transformed into 2-ethylaziridine by means of esterification with sulphuric acid followed by treatment with alkali. 2-Ethylaziridine is then submitted to a reaction with aromatic carboxylic acid or with aromatic orthobicarboxylic acid anhydride which produces the corresponding monomeric or polymeric amide, which is transformed into 2-aminobutanol by hydrolysis.The method of this invention is a multistage one but is quite simple and employs aqueous solutions and organic solvents, such as chloroform or benzene, which may be easily recovered.

    摘要翻译： 本发明涉及从容易获得的原料制备2-氨基丁醇的方法。 本发明的方法是基于1,2-环氧丁烷或异构丁烯卤化氢与氨的反应。 产物异构氨基丁醇随后通过用硫酸酯化转化成2-乙基氮丙啶，然后用碱处理。 然后将2-乙基氮丙啶与芳族羧酸或芳族邻苯二甲酸酐反应，产生相应的单体或聚合酰胺，其通过水解转化为2-氨基丁醇。

    N,N{40 -bridged-bis{8 2-alkyl-2-hydroxyethylamine{9 salts
    9.
    发明授权
    N,N{40 -bridged-bis{8 2-alkyl-2-hydroxyethylamine{9 salts 失效
    N，N {40-双 - 双{8 2-烷基-2-羟乙胺{9盐

    公开(公告)号：US3928427A

    公开(公告)日：1975-12-23

    申请号：US33226773

    申请日：1973-02-14

    申请人： STERLING DRUG INC

    发明人： DIANA GUY D ,  CUTLER ROYAL A

    IPC分类号： C07C291/04 ,  C07C91/02

    CPC分类号： C07C291/04

    摘要： N,N''-Bridged-Bis(2-alkyl-2-Hydroxyethylamine)salts of the formula

    are prepared by condensing an epoxide of the formula

    and a diamine of the formula R''NH-X-NHR''. The products and dicarbanilates, acid-addition salts, N,N''-dioxides and N,N''diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.

    摘要翻译： 通过将式HOR'R'OH |||R-CH-CH2-NXN-CH2-CH-R的N，N'-桥连双 - [2-烷基-2-羟基乙胺]盐通过将 式O || R-CH-CH 2和式R'NH-X-NHR'的二胺。 由其衍生的产物和二羧酸酯，酸加成盐，N，N'-二氧化物和N，N'-二铵季盐在体外具有抗菌活性，可用作抗菌剂。