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1.发明申请SYSTEMS AND METHODS FOR CARDIAC ABLATION USING LASER INDUCED OPTICAL BREAKDOWN 审中-公开使用激光诱导光学断裂进行心脏吸收的系统和方法公开(公告)号：US20090198223A1
公开(公告)日：2009-08-06
申请号：US12297012
申请日：2007-04-02
申请人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
发明人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
CPC分类号： A61B18/24 , A61B2017/00243 , A61B2018/2266
摘要： Systems and methods for achieving sub-surface, highly spatially selective cardiac ablation by means of laser induced optical breakdown (LIOB) are disclosed. Damage to non-targeted heart and artery/vein tissue is to be minimized according to the present disclosure. A catheter enters the heart, e.g., via a vein, and catheter location is determined/confirmed. Laser pulses are guided through the optical path within the catheter and, at or near the catheter end, a focusing structure is provided that focuses the laser radiation through the non-targeted vein/heart tissue into the targeted tissue. In the focusing structure, laser induced LIOB occurs and related mechanical effects affect the targeted tissue.
摘要翻译： 公开了通过激光诱导光学击穿（LIOB）实现子表面，高度空间选择性心脏消融的系统和方法。 根据本公开，要使对非靶向心脏和动脉/静脉组织的损伤最小化。 导管例如通过静脉进入心脏，并且确定/确认导管位置。 激光脉冲被引导通过导管内的光路，并且在导管末端处或附近提供聚焦结构，其将激光辐射通过非靶向静脉/心脏组织聚焦到目标组织中。 在聚焦结构中，激光诱导的LIOB发生并且相关的机械效应影响目标组织。
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公开(公告)号：US08821482B2
公开(公告)日：2014-09-02
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译： 本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。 激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。 这反过来又减少皱纹（30）。 该装置可以包括皱纹确定装置（52,54,56,58）。 聚焦光学元件（50）可以具有至少0.4的数值孔径。 本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。 优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。
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公开(公告)号：US20100063490A1
公开(公告)日：2010-03-11
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译： 本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。 激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。 这反过来又减少皱纹（30）。 该装置可以包括皱纹确定装置（52,54,56,58）。 聚焦光学元件（50）可以具有至少0.4的数值孔径。 本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。 优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。
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公开(公告)号：US06657361B1
公开(公告)日：2003-12-02
申请号：US09652934
申请日：2000-08-31
IPC分类号： H01L4108
CPC分类号： B26B19/282 , G11B7/08576 , H01L41/0913 , H02N2/008 , H02N2/026 , H02N2/103
摘要： The invention relates to a piezoelectric drive device with a bimodal piezoelectric resonator, with at least a first control electrode for triggering the resonator in a first drive direction, with at least a second control electrode for triggering the resonator in a second drive direction, and with a trigger circuit for supplying control signals to the first and the second control electrode. The invention is characterized in that a regulating circuit is provided for regulating the control signals, the second control electrode is designed for supplying a feedback signal to the regulating circuit when the resonator is being triggered in the first drive direction by means of the first control electrode, and the first control electrode is designed for supplying a feedback signal to the regulating circuit when the resonator is being triggered in the second drive direction by means of the second control electrode.
摘要翻译： 本发明涉及一种具有双峰型压电谐振器的压电驱动装置，至少具有用于在第一驱动方向上触发谐振器的第一控制电极，至少具有用于在第二驱动方向上触发谐振器的第二控制电极， 用于向第一和第二控制电极提供控制信号的触发电路。 本发明的特征在于提供一种用于调节控制信号的调节电路，第二控制电极被设计成当通过第一控制电极在第一驱动方向上触发谐振器时向调节电路提供反馈信号 并且第一控制电极被设计成当通过第二控制电极在第二驱动方向上触发谐振器时，向调节电路提供反馈信号。
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公开(公告)号：US07435966B2
公开(公告)日：2008-10-14
申请号：US10543563
申请日：2004-01-22
IPC分类号： G01T1/24
CPC分类号： G01T1/2018
摘要： The invention relates to an X-ray detector for detecting X-radiation, as used, in particular, in computer tomographic (CT) systems. The X-ray detector in accordance with the invention is composed of a photo sensor device, which comprises individual detector elements (1), above which scintillator elements (2) are disposed. These convert the incident X-ray light (6) into visible or UV light (7), which is detected by a photodiode (4) located on the detector element (1). In accordance with the invention, a micro-lens (3), which focuses the light (7) departing from the scintillator element (2) onto the photodiode (4), is disposed between the scintillator element (2) and the detector element (1). It is possible, in this manner, to use large areas of the detector element (1) for further electronic components (5) outside the photodiode (4), and, at the same time, to ensure a high DQE (Detection Quantum Efficiency) in that the light (7) departing from the scintillator element (2) is virtually fully exploited. The crosstalk from scatter radiation from adjacent detector elements is effectively prevented simultaneously.
摘要翻译： 本发明涉及用于检测X射线的X射线检测器，特别是在计算机断层摄影（CT）系统中使用。 根据本发明的X射线检测器由光传感器装置组成，该光传感器装置包括单独的检测器元件（1），其上设置有闪烁体元件（2）。 这些将入射的X射线光（6）转换成由位于检测器元件（1）上的光电二极管（4）检测到的可见光或紫外光（7）。 根据本发明，将从闪烁体元件（2）离开的光（7）聚焦到光电二极管（4）上的微透镜（3）设置在闪烁体元件（2）和检测器元件（ 1）。 以这种方式，可以将大面积的检测器元件（1）用于在光电二极管（4）外部的另外的电子部件（5），同时，为了确保高的DQE（检测量子效率） 因为从闪烁体元件（2）出发的光（7）实际上被充分利用。 来自相邻检测器元件的散射辐射的串扰被有效地同时防止。
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公开(公告)号：US20080001736A1
公开(公告)日：2008-01-03
申请号：US11570103
申请日：2005-06-01
IPC分类号： G08B21/00
CPC分类号： H04N5/37455 , H04N5/32
摘要： The present invention relates to an electronic circuit for reading out a plurality of sensor elements while disadvantages like degradation of analog signal transfer is avoided. The electronic circuit comprises a plurality of sensor elements (1, 11, 1-2, . . . ), each having at least a first and a second state and an output that conveys a trigger signal when the sensor element (1, 1-1, 1-2, . . . ) switches from the first state to the second state, a plurality of registers (R-1, R-2, . . . ) that are coupled to the outputs of the sensor elements (1, 1-1, 1-2, . . . ), a counter (CNT) that in an active state conveys a counter signal that is changing with a given clock rate, means for storing the counter signal into one of the registers (R1) when the trigger signal of one of the sensor elements (1-1 Y is received, and means for uniquely assigning the stored counter signal to the triggering sensor element (1-1).
摘要翻译： 本发明涉及一种用于读出多个传感器元件的电子电路，同时避免了模拟信号传输劣化的缺点。 电子电路包括多个传感器元件（1,11-1-2），每个具有至少第一和第二状态的传感器元件和输出，当传感器元件（1,1-1） 多个寄存器（R 1，R 2，...，...）从第一状态切换到第二状态，多个寄存器（R 1，R 2，...）耦合到传感器元件（1， 1，1〜2，...），处于活动状态的计数器（CNT）传送以给定时钟速率变化的计数器信号，用于将计数器信号存储到寄存器（R 1 ）当接收到传感器元件（1-1Y）中的一个的触发信号时，以及用于将存储的计数器信号唯一地分配给触发传感器元件（1-1）的装置）。
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公开(公告)号：US20070206725A1
公开(公告)日：2007-09-06
申请号：US10573743
申请日：2004-09-24
IPC分类号： H05G1/30
摘要： An X-ray unit according to the invention has a first arrangement (2) that is intended for the contactless and X-ray free measurement of first data of an object (1). A control unit (3) controls, on the basis of the first data of the object, a second arrangement (4) that measures X-ray data of the object by means of X-rays. With such an X-ray unit, first data 5 of the object can be obtained without using X-rays and control of the measurement of the Xray data is made possible, with the result that, data, only a minimum X-ray dose is applied to the object.
摘要翻译： 根据本发明的X射线单元具有用于对物体（1）的第一数据进行非接触式和无X射线测量的第一布置（2）。 控制单元（3）基于物体的第一数据来控制通过X射线测量物体的X射线数据的第二装置（4）。 利用这样的X射线单元，可以在不使用X射线的情况下获得物体的第一数据5，并且可以控制X射线数据的测量，结果是仅将最小X射线剂量 应用于对象。
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公开(公告)号：US20060138335A1
公开(公告)日：2006-06-29
申请号：US10543563
申请日：2004-01-22
IPC分类号： G01T1/20
CPC分类号： G01T1/2018
摘要： The invention relates to an X-ray detector for detecting X-radiation, as used, in particular, in computer tomographic (CT) systems. The X-ray detector in accordance with the invention is composed of a photo sensor device, which comprises individual detector elements (1), above which scintillator elements (2) are disposed. These convert the incident X-ray light (6) into visible or UV light (7), which is detected by a photodiode (4) located on the detector element (1). In accordance with the invention, a micro-lens (3), which focuses the light (7) departing from the scintillator element (2) onto the photodiode (4), is disposed between the scintillator element (2) and the detector element (1). It is possible, in this manner, to use large areas of the detector element (1) for further electronic components (5) outside the photodiode (4), and, at the same time, to ensure a high DQE (Detection Quantum Efficiency) in that the light (7) departing from the scintillator element (2) is virtually fully exploited. The crosstalk from scatter radiation from adjacent detector elements is effectively prevented simultaneously.
摘要翻译： 本发明涉及用于检测X射线的X射线检测器，特别是在计算机断层摄影（CT）系统中使用。 根据本发明的X射线检测器由光传感器装置组成，该光传感器装置包括单独的检测器元件（1），其上设置有闪烁体元件（2）。 这些将入射的X射线光（6）转换成由位于检测器元件（1）上的光电二极管（4）检测到的可见光或紫外光（7）。 根据本发明，将从闪烁体元件（2）离开的光（7）聚焦到光电二极管（4）上的微透镜（3）设置在闪烁体元件（2）和检测器元件（ 1）。 以这种方式，可以将大面积的检测器元件（1）用于在光电二极管（4）外部的另外的电子部件（5），同时，为了确保高的DQE（检测量子效率） 因为从闪烁体元件（2）出发的光（7）实际上被充分利用。 来自相邻检测器元件的散射辐射的串扰被有效地同时防止。
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公开(公告)号：US07058547B2
公开(公告)日：2006-06-06
申请号：US10515882
申请日：2003-05-19
IPC分类号： G06T15/00
CPC分类号： A61B6/032
摘要： A data acquisition system which includes data generating and processing units (1a, 1b, 1c), each of which includes a respective data source (3a1, 3a2, 3b1, 3c1) which serves to generate data. The data each time generated is processed by means of associated data processing means (2a, 2b, 2c 11a1, 11a2, 12a1, 12a2, 13a1, 13a2) in such a manner that each time a digital data word which comprises at least two bits is presented for output. The output of the digital data words takes place in synchronous-parallel fashion in dependence on first control signals (4, 5). Shift registers (6a, 6b, 6c) which are coupled to one another so as to form a chain propagate the digital data words in synchronous-parallel fashion in dependence on second control signals (7, 8) and are coupled to a respective associated data generating and processing unit (1a, 1b, 1c).
摘要翻译： 一种数据采集系统，包括数据产生和处理单元（1a，1b，1c），每个数据生成和处理单元包括相应的数据源（3a，1,3a，2,3b，1,3c1） 生成数据。 每次产生的数据通过相关联的数据处理装置（2a，2b，2c11a，11a，2da，1,2a，2,3a，a1a，1,2,3a）处理， 每次提供包括至少两个比特的数字数据字用于输出的方式。 根据第一控制信号（4,5），数字数据字的输出以同步并行的方式发生。 彼此耦合以形成链的移位寄存器（6a，6b，6c）根据第二控制信号（7,8）以同步并行的方式传播数字数据字，并且耦合到 各个相关联的数据产生和处理单元（1a，1b，1c）。
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公开(公告)号：US20050216236A1
公开(公告)日：2005-09-29
申请号：US10515882
申请日：2003-05-19
CPC分类号： A61B6/032
摘要： A data acquisition system which includes data generating and processing units (1a, 1b, 1c), each of which includes a respective data source (3a1, 3a2, 3b1, 3c1) which serves to generate data. The data each time generated is processed by means of associated data processing means (2a, 2b, 2c 11a1, 11a2, 12a1, 12a2, 13a1, 13a2) in such a manner that each time a digital data word which comprises at least two bits is presented for output. The output of the digital data words takes place in synchronous-parallel fashion in dependence on first control signals (4, 5). Shift registers (6a, 6b, 6c) which are coupled to one another so as to form a chain propagate the digital data words in synchronous-parallel fashion in dependence on second control signals (7, 8) and are coupled to a respective associated data generating and processing unit (1a, 1b, 1c).
摘要翻译： 一种数据采集系统，包括数据产生和处理单元（1a，1b，1c），每个数据生成和处理单元包括相应的数据源（3a，1,3a，2,3b，1,3c1） 生成数据。 每次产生的数据通过相关联的数据处理装置（2a，2b，2c11a1,11a，2a，12a，1,2a，2,3a，1,3a，a2a）进行处理 每次提供包括至少两个比特的数字数据字用于输出的方式。 根据第一控制信号（4,5），数字数据字的输出以同步并行的方式发生。 彼此耦合以形成链的移位寄存器（6a，6b，6c）根据第二控制信号（7,8）以同步并行方式传播数字数据字，并且耦合到 各个相关联的数据产生和处理单元（1a，1b，1c）。
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