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公开(公告)号：US09040234B2
公开(公告)日：2015-05-26
申请号：US13218259
申请日：2011-08-25
IPC分类号： A61K31/713 , A61K31/7084 , A61P31/00 , A61P31/12 , C07H21/04 , C12Q1/68 , C12Q1/70 , C25B7/00 , G01N27/447 , G01N33/559
CPC分类号： C12N15/1131 , A61K31/7084 , A61K31/713 , C07H21/04 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2320/30
摘要： The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention.It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.
摘要翻译： 本发明涉及可用于各种治疗应用的短寡核苷酸及其类似物（例如，二核苷酸和三核苷酸化合物）的设计。 据信本发明的化合物可以用作抗病毒剂，抗癌剂等。 在某些实施方案中，本发明的化合物可以调节免疫刺激途径和非TLR途径。 本发明还涉及用于治疗应用的设计修饰的寡核苷酸，通过从经修饰的寡核苷酸排除具有脱靶效应的核苷酸区段。 另一方面，本发明提供包含一种或多种本发明化合物的药物组合物。 据信本文所述的化合物和组合物具有针对各种疾病（包括病毒性疾病，自身免疫性疾病（例如过敏，哮喘和炎性疾病））和癌症的治疗效用。
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公开(公告)号：US20120053226A1
公开(公告)日：2012-03-01
申请号：US13218259
申请日：2011-08-25
IPC分类号： A61K31/713 , A61K31/7084 , C12Q1/70 , C12Q1/68 , G01N33/559 , A61P31/12 , A61P31/00 , G01N27/447 , C25B7/00 , C07H21/04 , A61P35/00
CPC分类号： C12N15/1131 , A61K31/7084 , A61K31/713 , C07H21/04 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2320/30
摘要： The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention.It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.
摘要翻译： 本发明涉及可用于各种治疗应用的短寡核苷酸及其类似物（例如，二核苷酸和三核苷酸化合物）的设计。 据信本发明的化合物可以用作抗病毒剂，抗癌剂等。 在某些实施方案中，本发明的化合物可以调节免疫刺激途径和非TLR途径。 本发明还涉及用于治疗应用的设计修饰的寡核苷酸，通过从经修饰的寡核苷酸排除具有脱靶效应的核苷酸区段。 另一方面，本发明提供包含一种或多种本发明化合物的药物组合物。 据信本文所述的化合物和组合物具有针对各种疾病（包括病毒性疾病，自身免疫性疾病（例如过敏，哮喘和炎性疾病））和癌症的治疗效用。
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公开(公告)号：US4135702A
公开(公告)日：1979-01-23
申请号：US737039
申请日：1976-10-29
CPC分类号： F27D13/002 , Y10S266/901
摘要： A metal batch preheating method comprises positioning an elongate mass of metal scrap on a conveyor in a tunnel furnace for heating such furnace having longitudinally spaced transversely extending zones of greater and lesser heat, the conveyor being loaded with metal for the length of the tunnel furnace except for the last heat zones therein. The metal is thereafter moved through a plurality of "advance and heat" movements in the furnace during the batch heating cycle so that the metal is exposed to both greater intensity and lesser intensity heat zones as it is preheated after which the metal is discharged for use or further processing.
摘要翻译： 金属批量预热方法包括将细长的金属废料块定位在隧道炉中的输送机上，用于加热这种具有较大和较小热量的纵向间隔的横向延伸区域的炉子，输送机装载有隧道炉长度的金属， 其中最后一个热区。 此后，金属在批量加热循环中在炉中移动多次“进行和加热”运动，使得金属在预热时暴露于较大强度和较小强度的热区，之后将金属排出使用 或进一步处理。
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