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公开(公告)号：US20060189806A1
公开(公告)日：2006-08-24
申请号：US11351193
申请日：2006-02-09
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
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公开(公告)号：US08546608B2
公开(公告)日：2013-10-01
申请号：US13249738
申请日：2011-09-30
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
IPC分类号： C07F5/02
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
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公开(公告)号：US20090075936A1
公开(公告)日：2009-03-19
申请号：US12265998
申请日：2008-11-06
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和治疗诸如癌症和其它与蛋白酶体活性直接或间接相关的疾病的疾病的方法。
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公开(公告)号：US08283367B2
公开(公告)日：2012-10-09
申请号：US12265998
申请日：2008-11-06
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
IPC分类号： A01N43/40 , A01N43/46 , A61K31/44 , A61K31/40 , C07D211/70 , C07D213/55 , C07D207/46
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和治疗诸如癌症和其它与蛋白酶体活性直接或间接相关的疾病的疾病的方法。
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公开(公告)号：US07915236B2
公开(公告)日：2011-03-29
申请号：US12496359
申请日：2009-07-01
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。
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公开(公告)号：US20090291918A1
公开(公告)日：2009-11-26
申请号：US12496359
申请日：2009-07-01
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。
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公开(公告)号：US20120041196A1
公开(公告)日：2012-02-16
申请号：US13249738
申请日：2011-09-30
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassará , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassará , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
IPC分类号： C07F5/02
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。
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公开(公告)号：US08058262B2
公开(公告)日：2011-11-15
申请号：US13020425
申请日：2011-02-03
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
IPC分类号： A61K31/69
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
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公开(公告)号：US20110144033A1
公开(公告)日：2011-06-16
申请号：US13020425
申请日：2011-02-03
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Sankar Chatterjee , Germano D'Arasmo , Sergio De Munari , Edmondo Ferretti , Mohamed Iqbal , Ernesto Menta , Patricia A. Messina McLaughlin , Ambrogio Oliva
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。
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公开(公告)号：US07468383B2
公开(公告)日：2008-12-23
申请号：US11351193
申请日：2006-02-09
申请人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
发明人： Raffaella Bernardini , Alberto Bernareggi , Paolo G. Cassara , Germano D'Arasmo , Ernesto Menta , Ambrogio Oliva
IPC分类号： A01N43/40 , A01N43/36 , A61K31/44 , A61K31/40 , C07D211/70 , C07D211/82 , C07D213/55 , C07D207/04 , C07D207/46 , C07D295/00
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和治疗诸如癌症和其它与蛋白酶体活性直接或间接相关的疾病的疾病的方法。
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