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    Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells
    1.
    发明申请
    Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells 失效
    有机硫化合物，一种制备有机硫化合物的方法及其用于抑制肿瘤细胞生长的方法

    公开(公告)号：US20110190368A1

    公开(公告)日：2011-08-04

    申请号：US13057960

    申请日：2009-08-05

    申请人： Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    发明人： Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    IPC分类号： A61K31/40 ,  C07C317/08 ,  A61K31/105 ,  C07C327/00 ,  A61K31/21 ,  C07D209/48 ,  C07C311/00 ,  A61K31/18 ,  A61P35/00

    CPC分类号： A61K31/105 ,  A61K31/18 ,  A61K31/4035 ,  C07C323/65 ,  C07D209/48

    摘要： Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

    摘要翻译： 描述了通式（2）的有机硫化合物，其中R 1和R 2是直链或支链C 1 -C 5烷基; 直链或支链C 1 -C 5烯基，条件是R 1不是丙-1-烯基（烯丙基）; 取代的直链或支链C 1 -C 5烯基或取代的直链或支链C 1 -C 5烷基，其中取代基选自OR 3，NR 4 R 5，COOR 6，CON-R 7 R 8，其中R 3选自H，COR 9，对甲氧基苄基和三烷基甲硅烷基 其中R9是烷基或取代的烷基; R4N和R5是烷基或R4和R5一起形成苯二甲酰亚氨基; R6是烷基或取代的烷基; 并且R 7和R 8是烷基或取代的烷基; 取代或未取代的芳族化合物，其中R 1和R 2是苄基，对甲氧基苄基和/或邻甲氧基苄基和取代或未取代的杂芳族。 该化合物可用于抑制肿瘤细胞的生长和治疗癌症。 还描述了药物组合物和制备该化合物的方法。

    Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells
    4.
    发明授权
    Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells 失效
    有机硫化合物，一种制备有机硫化合物的方法及其用于抑制肿瘤细胞生长的用途

    公开(公告)号：US08524781B2

    公开(公告)日：2013-09-03

    申请号：US13057960

    申请日：2009-08-05

    申请人： Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    发明人： Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    IPC分类号： A61K31/105 ,  C07C325/02

    CPC分类号： A61K31/105 ,  A61K31/18 ,  A61K31/4035 ,  C07C323/65 ,  C07D209/48

    摘要： Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

    摘要翻译： 描述了通式（2）的有机硫化合物，其中R 1和R 2是直链或支链C 1 -C 5烷基; 直链或支链C 1 -C 5烯基，条件是R 1不是丙-1-烯基（烯丙基）; 取代的直链或支链C 1 -C 5烯基或取代的直链或支链C 1 -C 5烷基，其中取代基选自OR 3，NR 4 R 5，COOR 6，CON-R 7 R 8，其中R 3选自H，COR 9，对甲氧基苄基和三烷基甲硅烷基 其中R9是烷基或取代的烷基; R4N和R5是烷基或R4和R5一起形成苯二甲酰亚氨基; R6是烷基或取代的烷基; 并且R 7和R 8是烷基或取代的烷基; 取代或未取代的芳族化合物，其中R 1和R 2是苄基，对甲氧基苄基和/或邻甲氧基苄基和取代或未取代的杂芳族。 该化合物可用于抑制肿瘤细胞的生长和治疗癌症。 还描述了药物组合物和制备该化合物的方法。