公开(公告)号：US08563305B2

公开(公告)日：2013-10-22

申请号：US12433832

申请日：2009-04-30

申请人： Rafi Ahmed ,  Joseph Miller ,  Patrick C. Wilson ,  J. Donald Capra ,  Jens Wrammert

发明人： Rafi Ahmed ,  Joseph Miller ,  Patrick C. Wilson ,  J. Donald Capra ,  Jens Wrammert

IPC分类号： C12N5/06 ,  C12N5/02

CPC分类号： C07K16/1018 ,  C07K16/00

摘要： High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to negCD38highCD27high cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained at a time that the fraction of PBMC expressing antibody reactive to the antigen is at a high level. Sequences encoding heavy and light chain variable domains are prepared in a manner that allow production of molecules with natural heavy and light chain pairing.

摘要翻译： 描述了用于产生结合抗原的抗体分子的高效方法。 所述方法包括从富集PBMC的细胞样品中获得富含CD19highCD3negCD20的PBMC群体，从暴露于抗原的哺乳动物中将CD38highCD27高细胞从抗原中除去。 从在与抗原反应的表达抗体的PBMC的分数处于高水平的时刻获得的样品中分离细胞。 编码重链和轻链可变结构域的序列以允许生成具有天然重链和轻链配对的分子的方式制备。

公开(公告)号：US20100279352A1

公开(公告)日：2010-11-04

申请号：US12433832

申请日：2009-04-30

申请人： Rafi Ahmed ,  Joseph Miller ,  Patrick Wilson ,  Jens Wrammert

发明人： Rafi Ahmed ,  Joseph Miller ,  Patrick Wilson ,  Jens Wrammert

IPC分类号： C12P21/00

CPC分类号： C07K16/1018 ,  C07K16/00

摘要： High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to negCD38highCD27high cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained at a time that the fraction of PBMC expressing antibody reactive to the antigen is at a high level. Sequences encoding heavy and light chain variable domains are prepared in a manner that allow production of molecules with natural heavy and light chain pairing.

摘要翻译： 描述了用于产生结合抗原的抗体分子的高效方法。 所述方法包括从富集PBMC的细胞样品中获得富含CD19highCD3negCD20的PBMC群体，从暴露于抗原的哺乳动物中将CD38highCD27高细胞从抗原中除去。 从在与抗原反应的表达抗体的PBMC的分数处于高水平的时刻获得的样品中分离细胞。 编码重链和轻链可变结构域的序列以允许生成具有天然重链和轻链配对的分子的方式制备。

公开(公告)号：US08533453B2

公开(公告)日：2013-09-10

申请号：US12046649

申请日：2008-03-12

申请人： Joseph Miller ,  Levente Batizy

发明人： Joseph Miller ,  Levente Batizy

IPC分类号： H04L29/06

CPC分类号： H04L63/0823 ,  H04L63/0884 ,  H04L63/166 ,  H04L67/1002 ,  H04L67/1027

摘要： Systems and methods of the present invention provide for configuring a server and loading SSL information by dynamically loading SSL information into a template based on an implicit SSL-based configuration. A Proxy Server may be used to determine an IP address on which the incoming network request was received, implicitly configure a configuration file accordingly, determine if an SSL information is contained within a cache, on a disk or in a database for the IP address and dynamically load the SSL information into an implicit generic template.

摘要翻译： 本发明的系统和方法提供了通过基于隐含的基于SSL的配置将SSL信息动态加载到模板中来配置服务器并加载SSL信息。 可以使用代理服务器来确定接收到传入网络请求的IP地址，相应地隐含地配置配置文件，确定SSL信息是否包含在高速缓存，磁盘上或数据库中的IP地址，以及 将SSL信息动态加载到隐式通用模板中。

公开(公告)号：US20120260472A1

公开(公告)日：2012-10-18

申请号：US13086917

申请日：2011-04-14

申请人： Joseph Miller

发明人： Joseph Miller

IPC分类号： E03D11/00

CPC分类号： E03D1/306 ,  Y10T24/45215

摘要： The present invention is a stainless steel circular shaped toilet flapper ring device that attaches to a chain and an adjoining handle of a toilet that includes a ring body with a tubular interior, an internal spring set within the tubular interior that provides an internal coned feature, a slide piece that covers the internal spring that can be opened to attach the device to a chain and an adjoining handle of a toilet and a pair of slide stops disposed on each end of the internal spring that lock in place to close the device. The toilet flapper ring device can be utilized with both traditional and modern toilet models.

摘要翻译： 本发明是一种不锈钢圆形马桶挡板环装置，其附接到马桶的链条和相邻的把手，其包括具有管状内部的环形主体，设置在管状内部内部的内部弹簧，其提供内部锥形特征， 覆盖可以打开的内部弹簧的滑动件，以将装置连接到马桶的链条和相邻的手柄上，以及设置在内部弹簧的每个端部上的一对滑动止动件，其锁定就位以关闭装置。 厕所挡板环装置可与传统和现代厕所型号一起使用。

公开(公告)号：US08094879B2

公开(公告)日：2012-01-10

申请号：US12949250

申请日：2010-11-18

申请人： Karen Kalla ,  Patricia Alison LaFleur ,  Joseph Miller ,  Grover Owens

发明人： Karen Kalla ,  Patricia Alison LaFleur ,  Joseph Miller ,  Grover Owens

IPC分类号： G06K9/00 ,  G09B25/00

CPC分类号： A45D44/005 ,  A61B5/0059 ,  A61B5/1034 ,  A61B5/441 ,  G01J3/50 ,  G01J3/52 ,  G01J3/524 ,  G01N21/293

摘要： A tool including a frame that includes an aperture and a boundary marker disposed about the aperture. The boundary marker includes a first marker region disposed about the aperture and a second marker region disposed about the first marker region. The color of the first marker region is different from the color of the second marker region. The tool also includes a color correction scale disposed proximate to the aperture. The color correction scale has at least a first color correction region and a second color correction region. The color of the first and second color correction regions each have an LCh value of between L=73.5 C=15.3 h=55.6 and L=32.5 C=11.6 h=48.3.

摘要翻译： 一种包括框架的工具，该框架包括孔和围绕孔设置的边界标记。 边界标记包括围绕孔设置的第一标记区和围绕第一标记区设置的第二标记区。 第一标记区域的颜色与第二标记区域的颜色不同。 该工具还包括靠近该孔设置的颜色校正刻度。 颜色校正刻度具有至少第一颜色校正区域和第二颜色校正区域。 第一和第二颜色校正区域的颜色各自具有在L = 73.5℃= 15.3h = 55.6和L = 32.5℃= 11.6h = 48.3之间的LCh值。

公开(公告)号：US20110064307A1

公开(公告)日：2011-03-17

申请号：US12949250

申请日：2010-11-18

申请人： Karen Kalla ,  Patricia Alison LaFleur ,  Joseph Miller ,  Grover Owens

发明人： Karen Kalla ,  Patricia Alison LaFleur ,  Joseph Miller ,  Grover Owens

IPC分类号： G06K9/00

CPC分类号： A45D44/005 ,  A61B5/0059 ,  A61B5/1034 ,  A61B5/441 ,  G01J3/50 ,  G01J3/52 ,  G01J3/524 ,  G01N21/293

摘要： A tool including a frame that includes an aperture and a boundary marker disposed about the aperture. The boundary marker includes a first marker region disposed about the aperture and a second marker region disposed about the first marker region. The color of the first marker region is different from the color of the second marker region. The tool also includes a color correction scale disposed proximate to the aperture. The color correction scale has at least a first color correction region and a second color correction region. The color of the first and second color correction regions each have an LCh value of between L=73.5 C=15.3 h=55.6 and L=32.5 C=11.6 h=48.3.

摘要翻译： 一种包括框架的工具，该框架包括孔和围绕孔设置的边界标记。 边界标记包括围绕孔设置的第一标记区和围绕第一标记区设置的第二标记区。 第一标记区域的颜色与第二标记区域的颜色不同。 该工具还包括靠近该孔设置的颜色校正刻度。 颜色校正刻度具有至少第一颜色校正区域和第二颜色校正区域。 第一和第二颜色校正区域的颜色各自具有在L = 73.5℃= 15.3h = 55.6和L = 32.5℃= 11.6h = 48.3之间的LCh值。

公开(公告)号：US20090235067A1

公开(公告)日：2009-09-17

申请号：US12046649

申请日：2008-03-12

申请人： Joseph Miller ,  Levente Batizy

发明人： Joseph Miller ,  Levente Batizy

IPC分类号： H04L9/00

CPC分类号： H04L63/0823 ,  H04L63/0884 ,  H04L63/166 ,  H04L67/1002 ,  H04L67/1027

摘要： Systems and methods of the present invention provide for configuring a server and loading SSL information by dynamically loading SSL information into a template based on an implicit SSL-based configuration. A Proxy Server may be used to determine an IP address on which the incoming network request was received, implicitly configure a configuration file accordingly, determine if an SSL information is contained within a cache, on a disk or in a database for the IP address and dynamically load the SSL information into an implicit generic template.

摘要翻译： 本发明的系统和方法提供了通过基于隐含的基于SSL的配置将SSL信息动态加载到模板中来配置服务器并加载SSL信息。 可以使用代理服务器来确定接收到传入网络请求的IP地址，相应地隐含地配置配置文件，确定SSL信息是否包含在高速缓存，磁盘上或数据库中的IP地址，以及 将SSL信息动态加载到隐式通用模板中。

公开(公告)号：US07348297B2

公开(公告)日：2008-03-25

申请号：US10959666

申请日：2004-10-05

申请人： Kevin W. Smith ,  Joseph Miller ,  Larry W. Gatlin

发明人： Kevin W. Smith ,  Joseph Miller ,  Larry W. Gatlin

IPC分类号： C09K8/035

CPC分类号： B01D19/0404

摘要： Compounds of the formula H(CH2)zCOO—[C2H4O]xCyH2y+1 where z is 0-2, x is an integer from 1 to 5 and y is an integer from 4-9 are used as emulsion breakers and defoamers in formation treatment fluids in the recovery of hydrocarbons from subterranean formations. A preferred material has the formula HCOO—[C2H40]3C6H7.

摘要翻译： 式H（CH 2 CH 2）n CO 2 - [C 2 H 4 O]的化合物 其中z是0-2，x是1到5的整数，y是4-9的整数，其中z是0-2， 在地层处理液中用作破乳剂和消泡剂，用于从地层中回收碳氢化合物。 优选的材料具有式HCOO- [C 2 H 4 H 3 O] 3 C 6 H 7 。

公开(公告)号：US20070284098A1

公开(公告)日：2007-12-13

申请号：US11743373

申请日：2007-05-02

申请人： Joseph Miller

发明人： Joseph Miller

IPC分类号： E21B47/01

CPC分类号： E21B47/12

摘要： Disclosed herein is a sensor system having a sensor and at least one communication line operable with the sensor. The transmission medium is configured to convey data transmitted by the sensor to a remote location. The sensor transmits data on the communication line a plurality of times by at least two methods of transmission or modulation. Further disclosed herein is a method based on the foregoing. Further disclosed is a method of communicating by modifying a voltage amplitude of a signal and receiving the communication signal by employing a variable threshold detection circuit in the downhole device. Further disclosed is a system for communicating data between a downhole device and a remote location including a remote device for generating a communication signal, the remote device configured to modify a voltage amplitude of said communication signal.

摘要翻译： 这里公开了一种传感器系统，其具有传感器和可与传感器一起操作的至少一个通信线路。 传输介质被配置为将由传感器发送的数据传送到远程位置。 传感器通过至少两种传输或调制方式在通信线路上多次传输数据。 本文进一步公开的是基于上述的方法。 进一步公开的是通过在井下装置中采用可变阈值检测电路来修改信号的电压振幅并接收通信信号来进行通信的方法。 还公开了一种用于在井下装置和远程位置之间传送数据的系统，包括用于产生通信信号的远程装置，所述远程装置被配置为修改所述通信信号的电压幅度。

公开(公告)号：US20060122796A1

公开(公告)日：2006-06-08

申请号：US11007520

申请日：2004-12-08

申请人： Kevin McLaughlin ,  Joseph Miller

发明人： Kevin McLaughlin ,  Joseph Miller

IPC分类号： G01R31/00

CPC分类号： G01R31/006 ,  G01R31/343 ,  H02P29/0241

摘要： A method and apparatus for determining a fault in an electric motor (50) determines a calculated star voltage (Vstar—calc) of the electric motor. The calculated star voltage (Vstar—calc) is compared to a measured star voltage (Vstar—meas) of the electric motor (50) to determine a star voltage error (Vstar—err). The fault in the electric motor (50) is determined when the star voltage error (Vstar—err) exceeds a predetermined maximum star voltage error (Vstar—err—max).

摘要翻译： 用于确定电动机（50）中的故障的方法和装置确定计算的星形电压（V < / SUB>）。 将计算出的星形电压（V SUB）与测得的星形电压（V - 测量以确定星形电压误差（V < SUB> _{- ）。 当星形电压误差（V > err ）时，确定电动机（50）中的故障 超过预定的最大星形电压误差（V max ）。}