公开(公告)号：US20190094226A1

公开(公告)日：2019-03-28

申请号：US16199822

申请日：2018-11-26

Applicant: Raindance Technologies, Inc.

Inventor： Darren Roy Link ,  Michael L. Samuels

IPC: G01N33/573 ,  B01L3/00 ,  C12Q1/6804 ,  C12Q1/25 ,  C12Q1/6818 ,  G01N33/58 ,  G01N33/542 ,  C40B40/04 ,  C40B50/08 ,  B01F13/00 ,  B01F5/06 ,  B01J19/00 ,  G01N33/50 ,  B01F3/08 ,  C40B60/10 ,  C12Q1/6827 ,  B01L7/00 ,  G01N21/64

CPC classification number: G01N33/573 ,  B01F3/0807 ,  B01F5/0646 ,  B01F5/0653 ,  B01F13/0062 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00351 ,  B01J2219/00418 ,  B01J2219/00479 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00599 ,  B01J2219/0065 ,  B01J2219/00657 ,  B01J2219/00664 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12Q1/25 ,  C12Q1/6804 ,  C12Q1/6818 ,  C12Q1/6827 ,  C40B40/04 ,  C40B50/08 ,  C40B60/10 ,  G01N21/6428 ,  G01N21/6445 ,  G01N33/5008 ,  G01N33/542 ,  G01N33/582 ,  G01N2500/00

Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.

公开(公告)号：US20190030538A1

公开(公告)日：2019-01-31

申请号：US16105257

申请日：2018-08-20

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC: B01L3/00 ,  G01N1/28 ,  C12N9/36

CPC classification number: B01L3/502784 ,  B01D9/0072 ,  B01D2009/0086 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01J14/00 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00894 ,  B01J2219/00903 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0867 ,  B01L2400/0487 ,  B82Y30/00 ,  C07K14/43 ,  C12N9/2462 ,  C12Q1/6806 ,  C12Y302/01017 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  G01N1/28 ,  G01N35/08 ,  Y10T117/10 ,  Y10T137/0318 ,  Y10T436/117497 ,  Y10T436/143333 ,  Y10T436/25

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20180353959A1

公开(公告)日：2018-12-13

申请号：US16004676

申请日：2018-06-11

Applicant: Abbott Point of Care, Inc.

Inventor： John A. Verrant ,  John N. Blum ,  Vu Phan ,  Kaushal K. Verma ,  Elise G. Edson

IPC: B01L3/00 ,  B01F5/06 ,  B01F13/00

CPC classification number: B01L3/502715 ,  B01F5/0614 ,  B01F5/0618 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0652 ,  B01F13/0059 ,  B01F2005/0632 ,  B01F2005/0633 ,  B01F2215/0037 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2300/045 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/168 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0484 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/065 ,  B01L2400/0655 ,  B01L2400/086

Abstract: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.

公开(公告)号：US20180353913A1

公开(公告)日：2018-12-13

申请号：US16105042

申请日：2018-08-20

Applicant: Raindance Technologies, Inc.

Inventor： Darren Roy Link ,  Brian Hutchison ,  Michael L. Samuels ,  Michael Weiner

IPC: B01F3/08 ,  G01N33/50 ,  C40B50/08 ,  C40B40/04

CPC classification number: B01F3/0807 ,  B01F5/0646 ,  B01F5/0653 ,  B01F13/0062 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00351 ,  B01J2219/00418 ,  B01J2219/00479 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00599 ,  B01J2219/0065 ,  B01J2219/00657 ,  B01J2219/00664 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  C40B40/04 ,  C40B50/08 ,  G01N15/1459 ,  G01N33/5008 ,  G01N2015/1006 ,  G01N2500/00 ,  Y02A90/26

Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

公开(公告)号：US10058840B2

公开(公告)日：2018-08-28

申请号：US14387758

申请日：2010-08-26

Applicant: Dominique Roberge ,  Fabio Rainone ,  Wilhelm Quittmann ,  Michael Gottsponer ,  Markus Eyholzer

Inventor： Dominique Roberge ,  Fabio Rainone ,  Wilhelm Quittmann ,  Michael Gottsponer ,  Markus Eyholzer

IPC: B01J19/00 ,  B01F5/06 ,  B01F13/00 ,  B01F15/00 ,  B08B9/032 ,  B08B17/02

CPC classification number: B01J19/0093 ,  B01F5/0646 ,  B01F13/0059 ,  B01F15/00019 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00932 ,  B01J2219/0099 ,  B08B9/032 ,  B08B17/02 ,  B08B2209/005

Abstract: A method for preventing plugging of a continuous-reaction channel-system caused by a by-product of a continuous-reaction being carried out in said channel-system comprises the step of generating at least one ultrasonic wave travelling through said channel-system by coupling in a flow direction of at least one process fluid of a plurality of process fluids said at least one ultrasonic wave into said at least one process fluid.

公开(公告)号：US20180193837A1

公开(公告)日：2018-07-12

申请号：US15861205

申请日：2018-01-03

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC: B01L3/00 ,  C12Q1/44 ,  B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  C12P19/34 ,  B01J19/00 ,  G01N15/14 ,  G01N35/08 ,  B01L7/00 ,  B82Y30/00

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09988651B2

公开(公告)日：2018-06-05

申请号：US14466841

申请日：2014-08-22

Applicant: Cavitation Technologies, Inc.

Inventor： Roman Gordon ,  Igor Gorodnitsky ,  Maxim A. Promtov ,  Vijayanand Suryakant Moholkar

IPC: C12P19/14 ,  C12P7/10 ,  B01F5/06 ,  B01J10/00 ,  B01J19/00 ,  B01J19/02 ,  B01J19/24 ,  B01F13/10 ,  C12P19/02 ,  C11B3/00 ,  C11B3/04 ,  C11B3/16 ,  C10L1/02 ,  C11C3/00 ,  C12N1/38 ,  A23K10/37 ,  A23K50/10

CPC classification number: C12P19/14 ,  A23K10/37 ,  A23K50/10 ,  B01F5/0644 ,  B01F5/0646 ,  B01F5/0652 ,  B01F5/0653 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/1025 ,  B01F13/1027 ,  B01J10/002 ,  B01J19/0066 ,  B01J19/008 ,  B01J19/02 ,  B01J19/2415 ,  B01J2219/0218 ,  B01J2219/0231 ,  B01J2219/0245 ,  C10L1/02 ,  C10L1/023 ,  C11B3/001 ,  C11B3/006 ,  C11B3/04 ,  C11B3/16 ,  C11C3/003 ,  C12N1/38 ,  C12P7/10 ,  C12P19/02 ,  C12P2201/00 ,  Y02E50/16 ,  Y02P60/877

Abstract: A process for increasing alcohol yield from biomass (the form or agro- or forest residue, grains, hops, etc.), involving multiple hydrodynamic cavitation treatments of biomass filtrate—both before and after fermentation. Carbohydrates extracted from biomass are subjected to a first cavitation treatment to promote additional conversion into carbohydrates. The carbohydrates are then combined with bacterial species and nutrients, and allowed to ferment. The fermentation product is subjected to a second hydrodynamic cavitation treatment to promote further conversion of carbohydrates into bioalcohol. After distillation, the bioalcohol is subjected to a second hydrodynamic cavitation treatment to increase its purity.

公开(公告)号：US20170361321A1

公开(公告)日：2017-12-21

申请号：US15673955

申请日：2017-08-10

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC: B01L3/00 ,  B01F3/08 ,  B01J19/00 ,  B01L7/00 ,  B01F5/06 ,  B01F13/00

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09839890B2

公开(公告)日：2017-12-12

申请号：US11665099

申请日：2005-10-12

Applicant: Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: C40B30/00 ,  C40B50/00 ,  B01F13/00 ,  B01F5/06 ,  B01J19/00 ,  B01L3/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/04 ,  C40B30/04 ,  B01F3/08 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N35/10

CPC classification number: B01F13/0071 ,  B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5025 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N2035/1034

Abstract: The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

公开(公告)号：US20170144152A1

公开(公告)日：2017-05-25

申请号：US15380954

申请日：2016-12-15

Applicant: The Regents of the University of California

Inventor： Michelle Khine ,  Chi-Shuo Chen ,  Anthony Grimes ,  David Nate Breslauer ,  Luke Lee ,  Michael Dunlap ,  Ajay Gopinathan ,  Sayantani Ghosh

IPC: B01L3/00 ,  G03F7/00 ,  B01F13/00 ,  B01F5/06 ,  B81B1/00 ,  B81C1/00

CPC classification number: B01L3/502707 ,  B01F5/0057 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F2215/0037 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B81B1/002 ,  B81B2201/051 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00071 ,  B81C2201/0152 ,  B82Y40/00 ,  G03F7/0002 ,  H01L21/02269 ,  H01L21/02271

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.