Device and Method for Granulating, Agglomerating, Pelletising, Drying and/or Coating

    公开(公告)号:US20180325828A1

    公开(公告)日:2018-11-15

    申请号:US15971228

    申请日:2018-05-04

    摘要: Provided is a device for granulating, agglomerating, pelletising, drying and/or coating, the device including a swirl chamber, a distribution chamber, wherein the swirl chamber is separated from the distribution chamber by a base and wherein a powder to be granulated or a powder mixture to be granulated is presented in the swirl chamber, the device further including at least one agitator for thoroughly mixing the powder to be granulated or the powder mixture to be granulated and at least one addition device for a liquid, wherein the base is designed in several parts and at least one base part is horizontally and/or vertically displaceable, with the result that that the base becomes a distributor plate. Also provided is a method for granulating, agglomerating, pelletising, drying and/or coating using such a device and a base suitable for use as a distributor plate in a convective drying apparatus.

    Method for producing granules
    10.
    发明授权
    Method for producing granules 有权
    生产颗粒的方法

    公开(公告)号:US09011926B2

    公开(公告)日:2015-04-21

    申请号:US14488823

    申请日:2014-09-17

    IPC分类号: A61K9/16 B05D7/00 A61K31/4439

    摘要: In a production process of granules containing a biologically active substance, variation in the elution profile of the biologically active substance is reduced by heating the temperature of granules to about 50° C. or higher and maintaining the temperature for about 1 minute or longer. By setting the spray speed to about 90 mg/min or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1.5 g/cm2 or more, the variation in the elution profile of the biologically active substance from the granules is reduced.

    摘要翻译: 在含有生物活性物质的颗粒的生产方法中,通过将颗粒的温度加热至约50℃或更高并保持约1分钟或更长时间来降低生物活性物质的洗脱曲线的变化。 当喷雾含有生物活性物质的主剂的喷雾剂,同时喷涂粘合液体至核心并设定每单位面积的总进料重量时,通过将喷雾速度设定为每1g核心约90mg / min或更高 对于离心流化床包衣造粒机至约1.5g / cm 2或更高,来自颗粒的生物活性物质的洗脱曲线的变化减小。