专利检索 ap:("Rajinder Singh" OR "Ankush Argade" OR "Donald Payan" OR "Susan Molineaux" OR "Sacha Holland" OR "Jeffrey Clough" OR "Holger Keim" OR "Somasekhar Bhamidipati" OR "Catherine Sylvain" OR "Hui Li" OR "Alexander Rossi") AND inv:"Susan Molineaux" 第 1 页

1.

发明授权
2,4-pyrimidinediamine compounds and their uses 有权
标题翻译： 2,4-嘧啶二胺化合物及其用途

公开(公告)号：US07550460B2

公开(公告)日：2009-06-23

申请号：US11782581

申请日：2007-07-24

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/535

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。

2.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权

公开(公告)号：US20070293523A1

公开(公告)日：2007-12-20

申请号：US11539049

申请日：2006-10-05

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

3.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 审中-公开
标题翻译： 2,4-吡啶二胺化合物及其用途

公开(公告)号：US20070293522A1

公开(公告)日：2007-12-20

申请号：US11539041

申请日：2006-10-05

申请人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在各种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。

4.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权
标题翻译： 2,4-吡啶二胺化合物及其用途

公开(公告)号：US20080039622A1

公开(公告)日：2008-02-14

申请号：US11782581

申请日：2007-07-24

申请人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： C07D241/36 , C07D239/46 , C07D295/00

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。

5.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权

公开(公告)号：US20070293524A1

公开(公告)日：2007-12-20

申请号：US11539054

申请日：2006-10-05

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

6.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权

公开(公告)号：US20070293520A1

公开(公告)日：2007-12-20

申请号：US11539018

申请日：2006-10-05

申请人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

7.

发明授权
2,4-pyrimidinediamine compounds and their uses 有权

公开(公告)号：US09416112B2

公开(公告)日：2016-08-16

申请号：US14485045

申请日：2014-09-12

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： C07D239/48 , C07D409/12 , C07D413/12 , C07D403/12 , C07D401/12 , C07D405/12 , A61K31/519 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D498/04 , C07D265/36 , A61K31/5395 , C07D495/04 , C07F5/02 , C07D498/14 , C07D407/14

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

8.

发明授权
2,4-pyrimidinediamine compounds and their uses 有权
标题翻译： 2,4-嘧啶二胺化合物及其用途

公开(公告)号：US08835430B2

公开(公告)日：2014-09-16

申请号：US14038521

申请日：2013-09-26

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： C07D239/48 , C07D403/12 , C07D413/12 , A61K31/506 , A61K31/538 , A61K31/505 , A61K31/551 , A61K31/5383 , C07D405/12 , C07D405/14 , C07D409/12 , C07D401/12 , C07D409/14 , A61K31/5377 , C07D413/14 , A61K31/519 , C07D413/10 , C07D403/14 , C07D265/36 , C07D417/14 , A61K45/06 , C07D498/04 , C07D401/14 , C07D417/12

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。