公开(公告)号：US20180072756A1

公开(公告)日：2018-03-15

申请号：US15468467

申请日：2017-03-24

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D498/04 ,  C07D498/06 ,  C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  A61K31/506 ,  C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  A61K31/541 ,  C07D413/12

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/541 ,  A61P19/02 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/02 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

公开(公告)号：US08178671B2

公开(公告)日：2012-05-15

申请号：US10903263

申请日：2004-07-30

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D239/48 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  A61K31/506 ,  A61K31/498 ,  A61K31/5375 ,  A61K31/5383 ,  A61K31/5415 ,  A61P19/02

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮和/或其相关症状和多发性硬化症和/或其相关症状。

公开(公告)号：US20050209224A1

公开(公告)日：2005-09-22

申请号：US10903870

申请日：2004-07-30

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/542 ,  A61P37/00 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D498/02 ,  C07D498/04 ,  C07D498/06 ,  C07D43/02

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。

公开(公告)号：US20200017523A1

公开(公告)日：2020-01-16

申请号：US16360958

申请日：2019-03-21

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/14 ,  C07D498/02 ,  A61K31/538 ,  A61P19/02 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

公开(公告)号：US07452879B2

公开(公告)日：2008-11-18

申请号：US11539147

申请日：2006-10-05

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4523 ,  A61K31/5377 ,  A61K31/541 ,  A61P19/02 ,  A61P37/00

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。

公开(公告)号：US07122542B2

公开(公告)日：2006-10-17

申请号：US10903870

申请日：2004-07-30

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： A61K19/02 ,  A61K31/535 ,  C07D268/36

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

公开(公告)号：US20050234049A1

公开(公告)日：2005-10-20

申请号：US10903263

申请日：2004-07-30

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/542 ,  A61P37/00 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D498/02 ,  C07D498/04 ,  C07D498/06 ,  C07D43/02

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

公开(公告)号：US09751893B2

公开(公告)日：2017-09-05

申请号：US12487486

申请日：2009-06-18

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61K31/541 ,  A61K31/506 ,  A61P19/02 ,  C07D498/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/06

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

公开(公告)号：US20120253039A1

公开(公告)日：2012-10-04

申请号：US13442480

申请日：2012-04-09

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D498/04 ,  C07D403/12 ,  C07D495/04 ,  C07D491/056 ,  C07D413/12 ,  C07D497/04 ,  C07D513/04 ,  C07D471/04

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/541 ,  A61P19/02 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/02 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮和/或其相关症状和多发性硬化症和/或其相关症状。

公开(公告)号：US20090318687A1

公开(公告)日：2009-12-24

申请号：US12487486

申请日：2009-06-18

申请人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

发明人： Rajinder Singh ,  Ankush Argade ,  Hui Li ,  Somasekhar Bhamidipati ,  David Carroll ,  Catherine Sylvain ,  Jeffrey Clough ,  Holger Keim

IPC分类号： C07D239/48 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。