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    DNA vaccines against tumor growth and methods of use thereof
    1.
    发明申请
    DNA vaccines against tumor growth and methods of use thereof 失效
    针对肿瘤生长的DNA疫苗及其使用方法

    公开(公告)号：US20100136058A1

    公开(公告)日：2010-06-03

    申请号：US12462496

    申请日：2009-08-04

    申请人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    发明人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    IPC分类号： A61K39/02 ,  A61K39/00 ,  C12N1/21

    CPC分类号： A61K48/0008 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55527 ,  A61K2039/6031 ,  C12N2510/02 ,  Y02A50/484

    摘要： A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carrier. In a preferred embodiment, the polynucleotide construct is operably incorporated in an attenuated bacterial vector, such as an attenuated Salmonella typhimurium, particularly a doubly attenuated aroA- dam- S. typhimurium. Transformed host cells, methods of inhibiting tumor growth, of vaccinating a patient against cancer, and of delivering genetic material to a mammalian cell in vivo are also described.

    摘要翻译： 适用于引发针对癌细胞的免疫应答的DNA疫苗包括在药学上可操作地编码Fra-1蛋白（例如多聚遍在蛋白化的人Fra-1蛋白）和IL-18（例如人IL-18）的多核苷酸构建体 可接受的载体 在优选的实施方案中，多核苷酸构建体可操作地掺入减毒的细菌载体中，例如减毒的鼠伤寒沙门氏菌，特别是双重减毒的aroA-鼠伤寒沙门氏菌。 还描述了转化的宿主细胞，抑制肿瘤生长的方法，使患者接种癌症的疫苗，以及将体内遗传物质递送至哺乳动物细胞。

    DNA vaccines against tumor growth and methods of use therof
    4.
    发明授权
    DNA vaccines against tumor growth and methods of use therof 失效
    针对肿瘤生长的DNA疫苗及其使用方法

    公开(公告)号：US07569552B2

    公开(公告)日：2009-08-04

    申请号：US10574752

    申请日：2004-10-07

    申请人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    发明人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    IPC分类号： A01N43/04 ,  A61K48/00

    CPC分类号： A61K48/0008 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55527 ,  A61K2039/6031 ,  C12N2510/02 ,  Y02A50/484

    摘要： A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carrier. In a preferred embodiment, the polynucleotide construct is operably incorporated in an attenuated bacterial vector, such as an attenuated Salmonella typhimurium, particularly a doubly attenuated aroA− dam− S. typhimurium. Transformed host cells, methods of inhibiting tumor growth, of vaccinating a patient against cancer, and of delivering genetic material to a mammalian cell in vivo are also described.

    摘要翻译： 适用于引发针对癌细胞的免疫应答的DNA疫苗包括在药学上可操作地编码Fra-1蛋白（例如多聚泛素化的人Fra-1蛋白）和IL-18（例如人IL-18）的多核苷酸构建体 可接受的载体 在优选的实施方案中，多核苷酸构建体可操作地掺入减毒的细菌载体中，例如减毒的鼠伤寒沙门氏菌，特别是双重减毒的aroA-鼠伤寒沙门氏菌。 还描述了转化的宿主细胞，抑制肿瘤生长的方法，使患者接种癌症的疫苗，以及将体内遗传物质递送至哺乳动物细胞。

    NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY
    5.
    发明申请
    NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY 有权
    基于纳米颗粒的肿瘤靶向药物递送

    公开(公告)号：US20130330399A1

    公开(公告)日：2013-12-12

    申请号：US13820413

    申请日：2011-09-02

    申请人： Ralph A. Reisfeld ,  Rong Xiang ,  Yunping Luo ,  Debbie Liao ,  Ze Liu ,  Tingmei Chen ,  Si Chen ,  Dan Lu

    发明人： Ralph A. Reisfeld ,  Rong Xiang ,  Yunping Luo ,  Debbie Liao ,  Ze Liu ,  Tingmei Chen ,  Si Chen ,  Dan Lu

    IPC分类号： A61K47/48 ,  A61K9/127

    CPC分类号： A61K31/58 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/4164 ,  A61K31/704 ,  A61K47/28 ,  A61K47/6911 ,  A61K47/6913 ,  B82Y5/00

    摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.

    摘要翻译： 本发明提供了包含脂质体纳米颗粒的水分散体的含水肿瘤靶向脂质体纳米颗粒组合物。 纳米颗粒优选包封抗癌化学治疗剂，其可以加入到预形成的脂质体组合物中，或者可以在形成脂质体期间掺入脂质体中。 脂质体纳米颗粒包含与分散在水性载体中的纳米颗粒脂质体形式的一种或多种其它胶束或形成囊泡的脂质材料混合的豆粕靶向脂质。 优选的肿瘤靶向脂质体纳米颗粒组合物包含（a）脂肪组织靶向脂质组分，（b）两性离子脂质组分; （c）氨基取代的脂质成分; （d）中性脂质组分; 和（e）聚乙二醇缀合的脂质组分。 所述脂肪组分包含疏水性脂质部分，其与共轭结合部分共价连接。

    NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY
    6.
    发明申请
    NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY 有权
    基于纳米颗粒的肿瘤靶向药物递送

    公开(公告)号：US20120058177A1

    公开(公告)日：2012-03-08

    申请号：US13224399

    申请日：2011-09-02

    申请人： Ralph A. Reisfeld ,  Rong Xiang ,  Yunping Luo ,  Debbie Liao ,  Ze Liu ,  Tingmei Chen ,  Si Chen ,  Dan Lu

    发明人： Ralph A. Reisfeld ,  Rong Xiang ,  Yunping Luo ,  Debbie Liao ,  Ze Liu ,  Tingmei Chen ,  Si Chen ,  Dan Lu

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61K31/704 ,  B82Y5/00

    CPC分类号： A61K31/58 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/4164 ,  A61K31/704 ,  A61K47/28 ,  A61K47/6911 ,  A61K47/6913 ,  B82Y5/00

    摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.

    摘要翻译： 本发明提供了包含脂质体纳米颗粒的水分散体的含水肿瘤靶向脂质体纳米颗粒组合物。 纳米颗粒优选包封抗癌化学治疗剂，其可以加入到预形成的脂质体组合物中，或者可以在形成脂质体期间掺入脂质体中。 脂质体纳米颗粒包含与分散在水性载体中的纳米颗粒脂质体形式的一种或多种其它胶束或形成囊泡的脂质材料混合的豆粕靶向脂质。 优选的肿瘤靶向脂质体纳米颗粒组合物包含（a）脂肪组织靶向脂质组分，（b）两性离子脂质组分; （c）氨基取代的脂质成分; （d）中性脂质组分; 和（e）聚乙二醇缀合的脂质组分。 所述脂肪组分包含疏水性脂质部分，其与共轭结合部分共价连接。

    DNA vaccines against tumor growth and methods of use thereof
    7.
    发明授权
    DNA vaccines against tumor growth and methods of use thereof 失效
    针对肿瘤生长的DNA疫苗及其使用方法

    公开(公告)号：US08053421B2

    公开(公告)日：2011-11-08

    申请号：US12462496

    申请日：2009-08-04

    申请人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    发明人： Yunping Luo ,  Rong Xiang ,  Ralph A. Reisfeld

    IPC分类号： A61K48/00 ,  C12N15/74

    CPC分类号： A61K48/0008 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55527 ,  A61K2039/6031 ,  C12N2510/02 ,  Y02A50/484

    摘要： A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carrier. In a preferred embodiment, the polynucleotide construct is operably incorporated in an attenuated bacterial vector, such as an attenuated Salmonella typhimurium, particularly a doubly attenuated aroA− dam− S. typhimurium. Transformed host cells, methods of inhibiting tumor growth, of vaccinating a patient against cancer, and of delivering genetic material to a mammalian cell in vivo are also described.

    摘要翻译： 适用于引发针对癌细胞的免疫应答的DNA疫苗包括在药学上可操作地编码Fra-1蛋白（例如多聚泛素化的人Fra-1蛋白）和IL-18（例如人IL-18）的多核苷酸构建体 可接受的载体 在优选的实施方案中，多核苷酸构建体可操作地掺入减毒的细菌载体中，例如减毒的鼠伤寒沙门氏菌，特别是双重减毒的aroA-鼠伤寒沙门氏菌。 还描述了转化的宿主细胞，抑制肿瘤生长的方法，使患者接种癌症的疫苗，以及将体内遗传物质递送至哺乳动物细胞。

    Dna vaccines against tumor growth and methods of use thereof
    9.
    发明申请
    Dna vaccines against tumor growth and methods of use thereof 失效
    Dna疫苗抗肿瘤生长及其使用方法

    公开(公告)号：US20070110717A1

    公开(公告)日：2007-05-17

    申请号：US10574752

    申请日：2004-10-07

    申请人： Yunping Luo ,  Rong Xiang ,  Ralph Reisfeld

    发明人： Yunping Luo ,  Rong Xiang ,  Ralph Reisfeld

    IPC分类号： A61K48/00

    CPC分类号： A61K48/0008 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55527 ,  A61K2039/6031 ,  C12N2510/02 ,  Y02A50/484

    摘要： A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carrier. In a preferred embodiment, the polynucleotide construct is operably incorporated in an attenuated bacterial vector, such as an attenuated Salmonella typhimurium, particularly a doubly attenuated aroA- dam- S. typhimurium. Transformed host cells, methods of inhibiting tumor growth, of vaccinating a patient against cancer, and of delivering genetic material to a mammalian cell in vivo are also described.

    摘要翻译： 适用于引发针对癌细胞的免疫应答的DNA疫苗包括在药学上可操作地编码Fra-1蛋白（例如多聚遍在蛋白化的人Fra-1蛋白）和IL-18（例如人IL-18）的多核苷酸构建体 可接受的载体 在优选的实施方案中，多核苷酸构建体可操作地掺入减毒的细菌载体中，例如减毒的鼠伤寒沙门氏菌，特别是双重减毒的aroA-鼠伤寒沙门氏菌。 还描述了转化的宿主细胞，抑制肿瘤生长的方法，使患者接种癌症的疫苗，以及将体内遗传物质递送至哺乳动物细胞。