公开(公告)号：US6069478A

公开(公告)日：2000-05-30

申请号：US976753

申请日：1997-11-24

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： A61B5/055 ,  G01R33/46 ,  G01R33/483 ,  G01V3/00

CPC分类号： G01R33/485 ,  G01R33/4608 ,  G01R33/5607

摘要： A pure water subtraction method for eliminating interfering sidebands of residual water including spurious signals from extraneous sources such as eddy current effects, Bo magnetic field drift, patient motion and the like. Unsuppressed and partially water suppressed magnetic signal data are obtained, and a low frequency water-phase-correction is applied thereto. The water phase corrected partially suppressed data is subtracted from the water phase corrected unsuppressed data to get a pure water reference (i.e. metabolite signals cancel). A scaled version of the pure water reference is subtracted from the partially suppressed data to eliminate spurious water signals.

摘要翻译： 一种用于消除残留水的干扰边带的纯水减法方法，包括来自外部来源的杂散信号，如涡流效应，Bo磁场漂移，病人运动等。 获得未压缩和部分水分抑制的磁信号数据，并对其施加低频水相校正。 从水相校正的未压制数据中减去部分抑制数据的水相，以获得纯水参考（即代谢信号取消）。 从部分抑制的数据中减去纯水参考的缩放版本，以消除虚假的水信号。

公开(公告)号：US6137290A

公开(公告)日：2000-10-24

申请号：US26037

申请日：1998-02-19

申请人： Ralph E. Hurd ,  Napapon Sailasuta ,  James Tropp ,  Patrick L. Le Roux

发明人： Ralph E. Hurd ,  Napapon Sailasuta ,  James Tropp ,  Patrick L. Le Roux

IPC分类号： G01R33/48 ,  A61B5/055 ,  G01R33/483 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56527 ,  G01R33/483

摘要： Chemical shift error in proton magnetic resonance spectroscopy is reduced by applying a volume excitation pulse sequence such as PRESS and very selective out-of-volume saturation pulses to limit that volume to a volume-of-interest free of the misregistration errors associated with the excitation sequence. The resulting volume is then only limited by the very small chemical shift misregistration of the very selective saturation pulses.

摘要翻译： 通过施加诸如PRESS和非常选择性的体积不足量脉冲之类的体积激励脉冲序列来降低质子磁共振光谱学中的化学位移误差，以将该体积限制为没有与激发相关的不对准误差的感兴趣体积 序列。 所产生的体积然后仅受非常小的非常选择性饱和脉冲的化学位移配准的限制。

公开(公告)号：US6104191A

公开(公告)日：2000-08-15

申请号：US40648

申请日：1998-03-17

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/483 ,  G01V3/00

CPC分类号： G01R33/483

摘要： Disclosed is improved quantitative in vivo spectroscopy by means of F1-oversampled J-Resolved 2D spectroscopy. Reconstruction makes full use of internal signals for 2D water lineshape, T.sub.2 and partial volume correction, and analysis uses 2D complex model spectra fitting. The preferred embodiment of the new method integrates these features into PRESS localized brain spectroscopy and is carried out without the need for water suppression.

摘要翻译： 公开了通过F1过采样的J-分辨2D光谱来改进定量体内光谱。 重建充分利用2D水线形状，T2和部分体积校正的内部信号，分析采用2D复杂模型光谱拟合。 新方法的优选实施例将这些特征集成到PRESS局部脑光谱中，并且不需要水抑制而进行。

公开(公告)号：US5262723A

公开(公告)日：1993-11-16

申请号：US727203

申请日：1991-07-09

申请人： Ralph E. Hurd ,  Boban K. John ,  Harris D. Plant

发明人： Ralph E. Hurd ,  Boban K. John ,  Harris D. Plant

IPC分类号： G01N24/12 ,  G01R33/32 ,  G01R33/46 ,  G01R33/20

CPC分类号： G01R33/4633 ,  G01R33/4608

摘要： A signal function S(t.sub.1, t.sub.2) is obtained from a plurality of coherence transfer pathways in a single acquisition by preparing a molecular system in a coherent non-equilibrium state, and alternately and sequentially detecting signals at individual sampling points, in t.sub.2, from the plurality of coherence transfer pathways by using gradient refocusing of a new pathway after signal detection at a sampling point in another pathway. A frequency domain spectrum S(.omega..sub.1,.omega..sub.2) is constructed by first Fourier transforming the time domain signals S(t.sub.1, t.sub.2) in the t.sub.2 dimension and producing real and imaginary components which modulate as sine and cosine signals in t.sub.1. The real (.omega..sub.2) cosine (t.sub.1) components are combined with the imaginary (.omega..sub.2) sine (t.sub.1) components to form a complex data set S(t.sub.1, .omega..sub.2) that is amplitude modulated in t.sub.1. The complex data set is then Fourier transformed in the t.sub.1 dimension to construct in frequency domain spectrum S(.omega..sub.1, .omega..sub.2) which contains pure absorption lineshapes.

公开(公告)号：US20100283465A1

公开(公告)日：2010-11-11

申请号：US12844876

申请日：2010-07-28

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： G01R33/48

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/4833 ,  G01R33/5601 ,  G01R33/5617

摘要： A system for magnetic resonance (MR) spectroscopy includes a plurality of gradient coils positioned about a bore of a magnet and an RF coil assembly coupled to a pulse generator to emit RF pulse sequences and arranged to receive resulting MR signals from a subject of interest. A system control is also included in the MR spectroscopy system and is coupled to the plurality of gradient coils and the RF coil assembly. The system control is programmed to cause the RF coil assembly to emit a first RF pulse and a second RF pulse, wherein at least one of the first and second RF pulses is spectrally selective and at least one of the first and second RF pulses is spatially selective. The system control is also programmed to cause the RF coil assembly to emit a third RF pulse after a pre-defined time delay to generate a stimulated echo and detect MR signals resulting from the stimulated echo.

摘要翻译： 用于磁共振（MR）光谱的系统包括围绕磁体的孔定位的多个梯度线圈和耦合到脉冲发生器的RF线圈组件以发射RF脉冲序列并被布置成从感兴趣的对象接收所得到的MR信号。 系统控制也包括在MR光谱系统中并且耦合到多个梯度线圈和RF线圈组件。 系统控制被编程为使得RF线圈组件发射第一RF脉冲和第二RF脉冲，其中第一和第二RF脉冲中的至少一个是频谱选择性的，并且第一和第二RF脉冲中的至少一个在空间上 选择性 系统控制也被编程为使得RF线圈组件在预定义的时间延迟之后发射第三RF脉冲以产生受激回波并检测由受激回波产生的MR信号。

公开(公告)号：US20090189605A1

公开(公告)日：2009-07-30

申请号：US12022622

申请日：2008-01-30

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： G01R33/483 ,  G01R33/32

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/4833 ,  G01R33/5601 ,  G01R33/5617

摘要： A system for magnetic resonance (MR) spectroscopy includes a plurality of gradient coils positioned about a bore of a magnet and an RF coil assembly coupled to a pulse generator to emit RF pulse sequences and arranged to receive resulting MR signals from a subject of interest. A system control is also included in the MR spectroscopy system and is coupled to the plurality of gradient coils and the RF coil assembly. The system control is programmed to cause the RF coil assembly to emit a first RF pulse and a second RF pulse, wherein at least one of the first and second RF pulses is spectrally selective and at least one of the first and second RF pulses is spatially selective. The system control is also programmed to cause the RF coil assembly to emit a third RF pulse after a pre-defined time delay to generate a stimulated echo and detect MR signals resulting from the stimulated echo.

摘要翻译： 用于磁共振（MR）光谱的系统包括围绕磁体的孔定位的多个梯度线圈和耦合到脉冲发生器的RF线圈组件以发射RF脉冲序列并被布置成从感兴趣的对象接收所得到的MR信号。 系统控制也包括在MR光谱系统中并且耦合到多个梯度线圈和RF线圈组件。 系统控制被编程为使得RF线圈组件发射第一RF脉冲和第二RF脉冲，其中第一和第二RF脉冲中的至少一个是频谱选择性的，并且第一和第二RF脉冲中的至少一个在空间上 选择性 系统控制也被编程为使得RF线圈组件在预定义的时间延迟之后发射第三RF脉冲以产生受激回波并检测由受激回波产生的MR信号。

公开(公告)号：US20090060841A1

公开(公告)日：2009-03-05

申请号：US12045177

申请日：2008-03-10

申请人： Yi-Fen Yen ,  Ralph E. Hurd ,  Susan J. Kohler

发明人： Yi-Fen Yen ,  Ralph E. Hurd ,  Susan J. Kohler

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  G01R33/4818 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/5616

摘要： A system and method for MR imaging includes a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images. The apparatus further includes a controller programmed to determine a variable flip angle (VFA) sequence to excite a hyperpolarized material in a subject and to determine a delay period during which application of the VFA sequence is delayed after injection of a hyperpolarized contrast agent. The delay period is based on dynamic data of the hyperpolarized material acquired from the subject. The controller is also programmed to cause application of the VFA sequence to excite the hyperpolarized material in the subject and to acquire MR data from the hyperpolarized material using an isotropic centric phase encoding (iCPE) technique.

摘要翻译： 用于MR成像的系统和方法包括具有围绕磁体的孔定位的多个梯度线圈的磁共振成像（MRI）系统，以及RF收发器系统和由脉冲模块控制的RF开关以将RF信号传输到 RF线圈组件来获取MR图像。 该装置还包括被编程为确定可变翻转角（VFA）序列以激发受试者中的超极化材料并且确定在注射超极化造影剂之后VFA序列的施用被延迟的延迟期间的控制器。 延迟期是基于从受试者获得的超极化材料的动态数据。 控制器也被编程为使得VFA序列的应用激发受试者中的超极化材料并且使用各向同性中心相编码（iCPE）技术从超极化材料获取MR数据。

公开(公告)号：US5168229A

公开(公告)日：1992-12-01

申请号：US678831

申请日：1991-04-02

申请人： Ralph E. Hurd ,  Boban K. John ,  Harris D. Plant

发明人： Ralph E. Hurd ,  Boban K. John ,  Harris D. Plant

IPC分类号： G01N24/12 ,  G01R33/483

CPC分类号： G01R33/4833

摘要： A signal function S(t.sub.1, t.sub.2) is obtained from a plurality of coherence transfer pathways in a single acquisition by preparing a molecular system in a coherent non-equilibrium state, and alternately and sequentially detecting signals at individual sampling points, in t.sub.2, from the plurality of coherence transfer pathways by using gradient refocusing of a new pathway after siganl detection at a sampling point in another pathway. The gradient encoding and refocusing of coherence pathways can use inhomogeneous rf-pulses (B.sub.1 gradients) or B.sub.0 field gradients. The coherence transfer pathways can be sequentially selected in an arbitrary order.

公开(公告)号：US08812076B2

公开(公告)日：2014-08-19

申请号：US11562394

申请日：2006-11-21

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： A61B5/05

CPC分类号： G01R33/5601 ,  A61B5/055 ,  A61B5/742 ,  A61B5/7475 ,  A61K49/10 ,  G01R33/281 ,  G01R33/4608 ,  G01R33/485 ,  G01R33/5608

摘要： A system and method for improving available signal-to-noise ratio (SNR) and speed of MR imaging of hyperpolarized substances is disclosed. The system and method include decoupling spin effects of hydrogen nuclei from non-hydrogen nuclei of interest during sampling of MR signals therefrom. Though the hydrogen nuclei of the hyperpolarized substance may not be directly bonded to the non-hydrogen nuclei of interest, resonance splitting may still impact SNR. Long range decoupling improves T2* time, and thus preserves signal strength and available SNR.

摘要翻译： 公开了一种用于提高超极化物质的可用信噪比（SNR）和MR成像速度的系统和方法。 该系统和方法包括在从其中的MR信号的采样期间将氢原子的自旋效应从感兴趣的非氢核解耦。 尽管超极化物质的氢核可能不会直接与感兴趣的非氢核结合，但共振分裂仍可能影响SNR。 长距离去耦可提高T2 *时间，从而保持信号强度和可用信噪比。

公开(公告)号：US07772844B2

公开(公告)日：2010-08-10

申请号：US12022622

申请日：2008-01-30

申请人： Ralph E. Hurd

发明人： Ralph E. Hurd

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/4833 ,  G01R33/5601 ,  G01R33/5617

摘要： A system for magnetic resonance (MR) spectroscopy includes a plurality of gradient coils positioned about a bore of a magnet and an RF coil assembly coupled to a pulse generator to emit RF pulse sequences and arranged to receive resulting MR signals from a subject of interest. A system control is also included in the MR spectroscopy system and is coupled to the plurality of gradient coils and the RF coil assembly. The system control is programmed to cause the RF coil assembly to emit a first RF pulse and a second RF pulse, wherein at least one of the first and second RF pulses is spectrally selective and at least one of the first and second RF pulses is spatially selective. The system control is also programmed to cause the RF coil assembly to emit a third RF pulse after a pre-defined time delay to generate a stimulated echo and detect MR signals resulting from the stimulated echo.

摘要翻译： 用于磁共振（MR）光谱的系统包括围绕磁体的孔定位的多个梯度线圈和耦合到脉冲发生器的RF线圈组件以发射RF脉冲序列并被布置成从感兴趣的对象接收所得到的MR信号。 系统控制也包括在MR光谱系统中并且耦合到多个梯度线圈和RF线圈组件。 系统控制被编程为使得RF线圈组件发射第一RF脉冲和第二RF脉冲，其中第一和第二RF脉冲中的至少一个是频谱选择性的，并且第一和第二RF脉冲中的至少一个在空间上 选择性 系统控制也被编程为使得RF线圈组件在预定义的时间延迟之后发射第三RF脉冲以产生受激回波并检测由受激回波产生的MR信号。