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    MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
    5.
    发明授权
    MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs 有权
    MR光谱系统和诊断疼痛性和非痛性椎间盘的方法

    公开(公告)号：US08761860B2

    公开(公告)日：2014-06-24

    申请号：US12579371

    申请日：2009-10-14

    申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

    发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/407 ,  A61B5/4514 ,  A61B5/4824 ,  A61B5/7203 ,  G01R33/34069 ,  G01R33/3415 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/565 ,  G01R33/56527 ,  G06F19/00

    摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

    摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

    Method and apparatus for correcting distortion during magnetic resonance imaging
    6.
    发明授权
    Method and apparatus for correcting distortion during magnetic resonance imaging 有权
    用于校正磁共振成像期间畸变的方法和装置

    公开(公告)号：US08131048B2

    公开(公告)日：2012-03-06

    申请号：US12344922

    申请日：2008-12-29

    申请人： Guo Bin Li ,  Bi Da Zhang

    发明人： Guo Bin Li ,  Bi Da Zhang

    IPC分类号： G06K9/00

    CPC分类号： G01R33/561 ,  G01R33/4824 ,  G01R33/56509 ,  G01R33/56527 ,  G01R33/56536 ,  G01R33/56563

    摘要： In a method and apparatus for correcting distortion during magnetic resonance imaging k space data in a number of readout encoding directions, sampling points on the phase encoding lines are primarily in low frequency regions of k space and the number of such sampling points is less than that of all sampling points. A view angle tilting compensation gradient is superimposed on the axis of a layer selection gradient. The k space data acquired from the number of directions are then combined.

    摘要翻译： 在用于校正多个读出编码方向的磁共振成像k空间数据中的失真的方法和装置中，相位编码线上的采样点主要在k空间的低频区域中，并且这样的采样点的数量小于 的所有采样点。 视角倾斜补偿梯度叠加在层选择梯度的轴上。 然后组合从多个方向获得的k个空间数据。

    Method for Magnetic Resonance Imaging
    7.
    发明申请
    Method for Magnetic Resonance Imaging 有权
    磁共振成像方法

    公开(公告)号：US20110068790A1

    公开(公告)日：2011-03-24

    申请号：US12857370

    申请日：2010-08-16

    申请人： Ryan Chamberlain ,  Jang-Yeon Park ,  Michael G. Garwood

    发明人： Ryan Chamberlain ,  Jang-Yeon Park ,  Michael G. Garwood

    IPC分类号： G01R33/48

    CPC分类号： G01R33/5615 ,  G01R33/4835 ,  G01R33/5616 ,  G01R33/56527 ,  G01R33/56536 ,  G01R33/56554

    摘要： A method of magnetic resonance imaging based on rapid acquisition by sequential excitation and refocusing is provided. The method comprises turning on a first time-encoding gradient and applying an excitation pulse in the presence of the first time-encoding gradient. The excitation pulse excites magnetization sequentially along one spatial axis. Thereafter, a first refocusing pulse is applied. A second time-encoding gradient is turned on followed by a second refocusing pulse. A third time-encoding gradient is turned on and a signal is acquired in the presence of the third time-encoding gradient. The third time-encoding gradient sums to zero with the first time-encoding gradient and the second time-encoding gradient for sequential points in space.

    摘要翻译： 提供了一种通过顺序激发和重新聚焦快速获取的磁共振成像方法。 该方法包括打开第一时间编码梯度并在第一时间编码梯度的存在下施加激励脉冲。 激励脉冲沿着一个空间轴顺序地激发磁化。 此后，施加第一重聚焦脉冲。 第二次编码梯度被打开，接着是第二重新聚焦脉冲。 第三时间编码梯度被打开，并且在存在第三时间编码梯度的情况下获取信号。 第三时间编码梯度与空间中的连续点的第一时间编码梯度和第二时间编码梯度相加。

    Magnetic resonance imaging with bipolar multi-echo sequences
    8.
    发明授权
    Magnetic resonance imaging with bipolar multi-echo sequences 有权
    双极多回波序列的磁共振成像

    公开(公告)号：US07777486B2

    公开(公告)日：2010-08-17

    申请号：US11854687

    申请日：2007-09-13

    申请人： Brian Hargreaves ,  Wenmiao Lu

    发明人： Brian Hargreaves ,  Wenmiao Lu

    IPC分类号： G01V3/00

    CPC分类号： G01R33/56563 ,  G01R33/4828 ,  G01R33/5616 ,  G01R33/56527

    摘要： A method for magnetic resonance imaging (MRI) is provided. A magnetic resonance excitation is provided. A plurality of k-space echoes is acquired bi-directionally wherein at least one echo is an even echo acquired in a first direction and at least one echo is an odd echo acquired in a second direction opposite from the first direction. K-space echo realignment is corrected between the even and odd echoes. Field inhomogeneity induced artifacts are corrected. Chemical shift induced artifacts between at least two species are corrected.

    摘要翻译： 提供了一种用于磁共振成像（MRI）的方法。 提供磁共振激励。 双向获取多个k空间回波，其中至少一个回波是在第一方向上获取的偶数回波，并且至少一个回波是在与第一方向相反的第二方向获取的奇数回波。 在奇偶回波之间校正K空间回波重排。 校正了场不均匀性引起的伪像。 校正至少两种物质之间的化学位移诱导的伪影。

    METHOD FOR WATER-FAT SEPARATION AND T2* ESTIMATION IN AN MRI SYSTEM EMPLOYING MULTIPLE FAT SPECTRAL PEAKS AND FAT SPECTRUM SELF-CALIBRATION
    10.
    发明申请
    METHOD FOR WATER-FAT SEPARATION AND T2* ESTIMATION IN AN MRI SYSTEM EMPLOYING MULTIPLE FAT SPECTRAL PEAKS AND FAT SPECTRUM SELF-CALIBRATION 有权
    用于水分离和T2 *估计的方法在使用多个FAT谱峰和FAT谱自校准的MRI系统中

    公开(公告)号：US20090261823A1

    公开(公告)日：2009-10-22

    申请号：US12104842

    申请日：2008-04-17

    申请人： Huanzhou Yu ,  Scott B. Reeder

    发明人： Huanzhou Yu ,  Scott B. Reeder

    IPC分类号： G01R33/48 ,  G01R33/54

    CPC分类号： G01R33/4828 ,  G01R33/5607 ,  G01R33/56527

    摘要： NMR signal contributions from water and fat are separated using a model of the fat resonant frequency spectrum that has multiple resonant peaks. The relative frequencies of the multiple fat spectrum peaks are known a priori and their relative amplitudes are determined using a self-calibration process. With the determined relative amplitudes of the fat spectrum peaks, acquired NMR signals are modeled. Using this model and NMR signal data acquired at a plurality of echo times (TE), the signal contribution from multiple fat spectrum peaks is separated from the acquired NMR signal data. A combined image is alternatively produced from weighted contributions of the separated water and fat images. Additionally, a more accurate estimation of the apparent relaxation time and rate (T2* and R2*, respectively) is alternatively performed.

    摘要翻译： 使用具有多个共振峰的脂肪共振频谱的模型分离水和脂肪的NMR信号贡献。 多个脂肪谱峰的相对频率是先验已知的，它们的相对幅度使用自校准过程来确定。 利用确定的脂肪谱峰的相对幅度，对获得的NMR信号进行建模。 使用在多个回波时间（TE）下获得的该模型和NMR信号数据，从所获取的NMR信号数据中分离来自多个脂肪谱峰的信号贡献。 可以通过分离的水和脂肪图像的加权贡献来产生组合图像。 此外，替代地执行更明确地估计表观弛豫时间和速率（分别为T2 *和R2 *）。