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    Antiviral combinations
    3.
    发明授权
    Antiviral combinations 失效
    抗病毒组合

    公开(公告)号：US4897394A

    公开(公告)日：1990-01-30

    申请号：US8627

    申请日：1987-01-29

    申请人： Thomas P. Zimmerman ,  Gerald Wolberg

    发明人： Thomas P. Zimmerman ,  Gerald Wolberg

    IPC分类号： A61K31/52 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  A61P43/00

    CPC分类号： A61K31/52 ,  A61K31/55 ,  A61K31/70

    摘要： This invention relates to synergistic combinations of nucleoside analogues, which are converted to viral DNA polymerase inhibitors through the action of at least one virus-induced enzyme, and nucleoside transport inhibitors. These combinations are especially useful in combatting herpes virus infections.

    摘要翻译： 本发明涉及核苷类似物的协同组合，其通过至少一种病毒诱导的酶的作用转化为病毒DNA聚合酶抑制剂，以及核苷转运抑制剂。 这些组合在对抗疱疹病毒感染方面特别有用。

    Method for the inhibition of immune response
    4.
    发明授权
    Method for the inhibition of immune response 失效
    抑制免疫反应的方法

    公开(公告)号：US4309419A

    公开(公告)日：1982-01-05

    申请号：US84445

    申请日：1979-10-12

    申请人： Gerald Wolberg ,  Thomas P. Zimmerman

    发明人： Gerald Wolberg ,  Thomas P. Zimmerman

    IPC分类号： A61K31/70 ,  A61K31/195 ,  A61K31/33 ,  A61K31/425 ,  A61K31/7042 ,  A61K31/7052 ,  A61P37/06 ,  A61P43/00 ,  C07H19/052 ,  C07H19/23 ,  C07H19/16

    CPC分类号： C07H19/052

    摘要： Adenosine derivatives for inhibition of immune response are disclosed.Adenosine derivatives of formula (I) ##STR1## wherein R.sup.1 is amino or lower alkyl amino;R.sup.2 is hydrogen or an aliphatic carboxylic acid residue; andR.sup.3 is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue,are useful as inhibitors of immune response. The activity is potentiated by derivatives of homocysteine and homocystine. Particularly useful is 3-deaza-adenosine both alone and in combination with L-homocysteine thiolactone, Pharmaceutical formulations of compounds of formula (I) alone and with potentiators are provided.

    摘要翻译： 公开了用于抑制免疫应答的腺苷衍生物。 式（I）的腺苷衍生物其中R 1是氨基或低级烷基氨基; R2是氢或脂族羧酸残基; R3是氢，脂族羧酸残基或磷酸残基，可用作免疫应答的抑制剂。 活性由同型半胱氨酸和高半胱氨酸衍生物增强。 特别有用的是单独的和与L-高半胱氨酸硫内酯组合的3-脱氮腺苷，提供单独的式（I）化合物和增效剂的药物制剂。

    Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in treatment of inflammatory conditions and immune disorders
    6.
    发明授权
    Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in treatment of inflammatory conditions and immune disorders 有权
    取代的（1,3-双（环己基甲基）-1,2,3,6-四氢-2,6-二氧代-9H-嘌呤-8-基）苯基衍生物，其制备及其在治疗炎症和免疫中的应用 疾病

    公开(公告)号：US06355646B1

    公开(公告)日：2002-03-12

    申请号：US09367313

    申请日：1999-12-22

    申请人： Susan Mary Daluge ,  Gerald Wolberg ,  Douglas Alan Livingston

    发明人： Susan Mary Daluge ,  Gerald Wolberg ,  Douglas Alan Livingston

    IPC分类号： C07D47306

    CPC分类号： C07D473/06

    摘要： The present invention provides a compound of formula (I) or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH2—)p, (—CH═CH—)p, (—C≡C—)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S n is an integer of 1 to 50; and R is hydrogen or methyl. The present invention also provides pharmaceutical compositions and methods of treatment using the compounds of formula (I). The compounds of the present invention are useful for the prophylaxis and treatment of septic shock, inflammatory conditions and immune disorders.

    摘要翻译： 本发明提供了式（I）化合物或其溶剂合物，其中：X是-O-或-NH-; Q是（-CH 2 - ）p，（-CH = CH-）p，（-C = C - ）p其中p是0至4的整数; R1是氢或甲基; R2和R3独立地表示O或Sn是1至50的整数; 和R是氢或甲基。本发明还提供了使用式（I）化合物的药物组合物和治疗方法。 本发明的化合物可用于预防和治疗败血性休克，炎性病症和免疫疾病。