公开(公告)号：US4618691A

公开(公告)日：1986-10-21

申请号：US688101

申请日：1984-12-31

申请人： Ramiro Medina ,  Jack M. Sullivan

发明人： Ramiro Medina ,  Jack M. Sullivan

IPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/6593 ,  C07F9/22 ,  C12P3/00

CPC分类号： C05G3/08 ,  C01B21/097 ,  C07F9/65815

摘要： Tests show that 2,2,4,4,6,6-hexaaminocyclotriphosphazatriene, 2-phenoxy-2,4,4,6,6-pentaaminocyclotriphosphazatriene, 2,4-diphenoxy-2,4,6,6-tetraaminocyclotriphosphazatriene and 2,4,6-triphenoxy-2,4,6-triaminocyclotriphosphazatriene (also frequently called phosphonitrilic derivatives) of the formula ##STR1## are highly effective inhibitors of urease activity in agricultural soil systems wherein(1) R.sub.1 . . . R.sub.3 '=NH.sub.2 or(2) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.2 =R.sub.3 =NH.sub.2 and R.sub.1 =OC.sub.6 H.sub.5 or(3) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.3 =NH.sub.2 and R.sub.1 =R.sub.2 =OC.sub.6 H.sub.5 or(4) R.sub.1 '=R.sub.2 '=R.sub.3 '=NH.sub.2 and R.sub.1 =R.sub.2 =R.sub.3 =OC.sub.6 H.sub.5.

摘要翻译： 试验表明，2,2,4,4,6,6-六氨基环三磷杂三烯，2-苯氧基-2,4,4,6,6-五氨基环三磷杂三烯，2,4-二苯氧基-2,4,6,6-四氨基环三磷杂三烯和2 式（IMAGE）的4,6-三苯氧基-2,4,6-三氨基环三磷杂三烯（也称为次膦酸衍生物）是农业土壤系统中尿素酶活性的高效抑制剂，其中（1）R1。 。 。 R3'= NH2或（2）R1'= R2'= R3'= R2 = R3 = NH2且R1 = OC6H5或（3）R1'= R2'= R3'= R3 = NH2，R1 = R2 = OC6H5或（ 4）R1'= R2'= R3'= NH2，R1 = R2 = R3 = OC6H5。

公开(公告)号：US4670038A

公开(公告)日：1987-06-02

申请号：US899567

申请日：1986-08-21

申请人： Ramiro Medina ,  Jack M. Sullivan

发明人： Ramiro Medina ,  Jack M. Sullivan

IPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/6593 ,  C05C9/00

CPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/65815 ,  Y10S71/902

摘要： Test show that 2,2,4,4,6,6-hexaaminocyclotriphosphazatriene, 2-phenoxy-2,4,4,6,6-pentaaminocyclotriphosphazatriene, 2,4-diphenoxy-2,4,6,6-tetraaminocyclotriphosphazatriene and 2,4,6-triphenoxy-2,4,6-triaminocyclotriphosphazatriene (also frequently called phosphonitrilic derivatives) of the formula ##STR1## are highly effective inhibitors of urease activity in agricultural soil systems wherein(1) R.sub.1 . . . R.sub.3 '=NH.sub.2 or(2) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.2 =R.sub.3 =NH.sub.2 and R.sub.1 =OC.sub.6 H.sub.5 or(3) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.3 =NH.sub.2 and R.sub.1 =R.sub.2 =OC.sub.6 H.sub.5 or(4) R.sub.1 '=R.sub.2 '=R.sub.3 '=NH.sub.2 and R.sub.1 =R.sub.2 =R.sub.3 =OC.sub.6 H.sub.5.

摘要翻译： 测试表明，2,2,4,4,6,6-六氨基环三磷杂三烯，2-苯氧基-2,4,4,6,6-五氨基环三磷杂三烯，2,4-二苯氧基-2,4,6,6-四氨基环三磷杂三烯和2 式（IMAGE）的4,6-三苯氧基-2,4,6-三氨基环三磷杂三烯（也称为次膦酸衍生物）是农业土壤系统中尿素酶活性的高效抑制剂，其中（1）R1。 。 。 R3'= NH2或（2）R1'= R2'= R3'= R2 = R3 = NH2且R1 = OC6H5或（3）R1'= R2'= R3'= R3 = NH2，R1 = R2 = OC6H5或（ 4）R1'= R2'= R3'= NH2，R1 = R2 = R3 = OC6H5。

公开(公告)号：UST105605I4

公开(公告)日：1985-07-02

申请号：US625424

申请日：1984-06-28

申请人： Ramiro Medina ,  Jack M. Sullivan

发明人： Ramiro Medina ,  Jack M. Sullivan

IPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/6593

CPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/65815

摘要： Tests show that 2,2,4,4,6,6-hexaaminocyclotriphosphazatriene, 2-phenoxy-2,4,4,6,6-pentaaminocyclotriphosphazatriene, 2,4-diphenoxy-2,4,6,6-tetraaminocyclotriphosphazatriene and 2,4,6-triphenoxy-2,4,6-triaminocyclotriphosphazatriene (also frequently called phosphonitrilic derivatives) of the formula ##STR1## are highly effective inhibitors of urease activity in agricultural soil systems wherein(1) R.sub.1 . . . R.sub.3 '=NH.sub.2 or(2) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.2 =R.sub.3 =NH.sub.2 and R.sub.1 =OC.sub.6 H.sub.5 or(3) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.3 =NH.sub.2 and R.sub.1 =R.sub.2 =OC.sub.6 H.sub.5 or(4) R.sub.1 '=R.sub.2 '=R.sub.3 '=NH.sub.2 and R.sub.1 =R.sub.2 =R.sub.3 =OC.sub.6 H.sub.5The above-mentioned compounds and mixtures of the compounds show sustained inhibition of the soil urease activity for periods of at least 21 days.

公开(公告)号：US08450473B2

公开(公告)日：2013-05-28

申请号：US13266219

申请日：2010-04-30

申请人： Jack M. Sullivan

发明人： Jack M. Sullivan

IPC分类号： C07H21/04

CPC分类号： A61K31/711 ,  A61K31/7105 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/531

摘要： Provided are compositions and methods for therapy of macular degeneration including dry age-related macular degeneration (dAMD), juvenile macular degenerations (JMDs) where toxic retinoids are known to accumulate as part of the pathogenesis, such as Stargardt disease, and Best disease, and neovascular wet age-related macular degeneration. The method entails administering to an individual in need of therapy for macular degeneration a first polynucleotide that can facilitate a reduction in the amount of rod opsin (RHO) mRNA in the individual; or a second polynucleotide that can facilitate a reduction in the amount of RPE65 mRNA in the individual; or a combination thereof. The polynucleotides of the invention are hammerhead ribozymes or shRNAs. The polynucleotides target a sequence in RHO mRNA or RPE65 mRNA and facilitate reduction in the target mRNA via ribozymatic cleavage of the target, or by hybridization to the target, which leads to RNAi mediated degradation of the target mRNA.

摘要翻译： 提供用于治疗黄斑变性的组合物和方法，包括干性年龄相关性黄斑变性（dAMD），已知有毒类维生素A作为发病机理的一部分积累的青光眼黄斑变性（JMD），例如Stargardt病和Best病，以及 新生血管湿性年龄相关性黄斑变性。 该方法需要对需要治疗黄斑变性的个体施用第一种多核苷酸，其可以促进个体中杆视蛋白（ROS）mRNA的量的减少; 或可以促进个体中RPE65 mRNA的量减少的第二多核苷酸; 或其组合。 本发明的多核苷酸是锤头核酶或shRNA。 多核苷酸靶向RHO mRNA或RPE65 mRNA中的序列，并通过靶的核酶切割或通过与靶标杂交，促进靶mRNA的还原，导致靶向mRNA的RNAi介导的降解。

公开(公告)号：UST105301I4

公开(公告)日：1985-04-02

申请号：US612162

申请日：1984-05-21

申请人： Jack M. Sullivan ,  Yong K. Kim ,  Kjell R. Waerstad

发明人： Jack M. Sullivan ,  Yong K. Kim ,  Kjell R. Waerstad

IPC分类号： C05B11/06 ,  C05C9/00

CPC分类号： C05C9/00 ,  C05B11/06 ,  Y10S206/807

摘要： The present invention relates to the reaction of phosphate rock with nitric acid and urea to produce nitrogen-phosphorus containing slurries, which slurries may be granulated and dried to produce solid N-P fertilizer products with agronomically advantageous low pHs (1.1-4.0). Products with optimum physical and chemical properties were discovered by investigating the characteristics of each individual material as a function of the nitric acid acidulation ratio (mole ratio HNO.sub.3 :CaO) and the mole ratio urea:CaO present in each product. Acidulation ratios ranged from 1.2 to 2.1 while ratios urea:CaO ranged from 1.6 to 4.0. Selected products with optimum physicochemical properties are tabulated below:______________________________________ Acidulation Ratio Ratio Melting HNO.sub.3 :CaO, M/M Urea:CaO, M/M Grade Pt, .degree.C. ______________________________________ 1.2 2.2 23.8--11.7--0 137-139 1.4 2.4 25.0--11.0--0 136 1.6 2.8 25.9--9.9--0 133-137 1.8 3.0 26.4--9.2--0 134-135 2.0 3.3 27.2--8.7--0 130 2.1 3.2 36.6--8.8--0 125-130 ______________________________________ Acidulation P.sub.2 O.sub.5 Solubility, Critical Rela- Ratio % pH of 1% tive Humidity HNO.sub.3 :CaO, M/M Water Citrate solution at 25.degree. C., % ______________________________________ 1.2 69.2 82.1 2.5 59.3 1.4 81.8 90.0 2.4 60.9 1.6 88.9 91.9 2.3 60.1 1.8 96.7 98.9 2.1 59.9 2.1 99.0 100 2.1 60.0 2.1 100 100 2.1 59.5 ______________________________________ The products have excellent storage characteristics. The improved properties of these products result partially from the formation of a new compound, Ca(H.sub.2 PO.sub.4)(NO.sub.3).CO(NH.sub.2).sub.2, which was discovered during the course of the investigation that led to the instant invention.

公开(公告)号：US5098461A

公开(公告)日：1992-03-24

申请号：US458022

申请日：1989-12-28

申请人： Jack M. Sullivan ,  John H. Grinstead, Jr.

发明人： Jack M. Sullivan ,  John H. Grinstead, Jr.

IPC分类号： C05B3/00 ,  C05B11/06

CPC分类号： C05B3/00 ,  C05B11/06

摘要： A process for producing high-analysis dicalcium phosphate containing phosphatic fertilizers and by-product calcium nitrate. It comprises reacting phosphate rock with nitric acid, followed by pyrolysis of the resulting acidulate to effect liberation of approximately one-half of the initially consumed nitric acid. Recycling of this liberated nitric acid allows production of available phosphate with approximately one-half the acid equivalents normally consumed during sulfuric acid processing. The calcium nitrate in the resulting pyrolyzate is separated from the phosphatic constituent by dissolution in water followed by filtration. Depending upon the initial HNO.sub.3 :CaO acidulation ratio, the available phosphate content of the resulting solid phosphatic fertilizers is high enough (48% P.sub.2 O.sub.5) to allow their use either for bulk blending with nitrogen and potash salts to produce complete grade fertilizers or for direct application as a phosphate nutrient. The resulting calcium nitrate stream may be processed to produce a variety of solid or fluid nitrogen fertilizer products. No "throw away" by-products (other than possibly siliceous gangue) are produced.

摘要翻译： 一种生产高分析磷酸二钙和副产品硝酸钙的方法。 它包括使磷酸盐岩与硝酸反应，然后热解得到的酸化物，以释放大约一半的初始消耗的硝酸。 回收这种释放的硝酸允许生产可用的磷酸盐，其硫酸处理期间通常消耗的酸当量的约一半。 所得热解物中的硝酸钙通过溶解在水中而与磷酸盐成分分离，然后过滤。 根据最初的HNO3：CaO酸化比例，得到的固体磷酸盐肥料的可用磷酸盐含量足够高（48％P 2 O 5），以允许其与氮气和钾盐大量混合使用以产生完整的等级肥料或直接施用 作为磷酸盐营养。 所得到的硝酸钙流可以被加工以产生各种固体或流体氮肥产品。 副产品（不可能是硅质ang石）不产生。

公开(公告)号：UST100903I4

公开(公告)日：1981-08-04

申请号：US137204

申请日：1980-04-04

申请人： Robert J. Radel ,  Jack M. Sullivan

发明人： Robert J. Radel ,  Jack M. Sullivan

IPC分类号： C07C69/36 ,  C07C50/04 ,  C07C67/36 ,  C07C102/00 ,  C07C102/06

CPC分类号： C07C69/36

摘要： A process for the preparation of nitrogen fertilizers, especially oxamide, either indirectly or directly from oxalate esters, including the regeneration of the quinone oxidant utilized in the formation of the above esters.Preparation of oxalate esters by the oxidative carbonylation of alcohols with carbon monoxide in the presence of a catalytic amount of a platinum group metal salt with or without a corresponding metal oxidant salt and an optionally substituted quinone. High yields of isolated dialkyl oxalates are obtained by regulating temperature and carbon monoxide pressure and by maintaining essentially anhydrous conditions. In addition, high yields of the hydroquinones (1,4-dihydroxybenzenes) are recovered.Preparation of oxamide, a potential slow-release nitrogen fertilizer via the oxidative carbonylation of alcohols with carbon monoxide in the presence of a catalytic amount of a platinum group metal salt and an optionally substituted quinone followed by ammoniation of the filtered reaction mixture at room temperature, or below. High yields of isolated oxamide were obtained by regulating the temperature and pressure during the oxidative carbonylation and maintaining essentially anhydrous conditions throughout the process. In addition, nearly quantitative yields of the hydroquinones (1,4-dihydroxybenzenes) are recovered for recycle along with the solvents.

公开(公告)号：US5275639A

公开(公告)日：1994-01-04

申请号：US28877

申请日：1993-03-10

申请人： Jack M. Sullivan ,  Raymond D. Thrasher ,  Ronald E. Edwards

发明人： Jack M. Sullivan ,  Raymond D. Thrasher ,  Ronald E. Edwards

IPC分类号： C05B11/06 ,  C05B11/04

CPC分类号： C05B11/06

摘要： A process for oxidizing aqueous elemental phosphorus containing residues (sludges) to produce orthophosphate containing slurries suitable for subsequent reaction with ammonia to produce nitrogen- and phosphorus-containing fertilizer products. It comprises reacting aqueous elemental phosphorus containing residues with certain special mixtures of concentrated nitric acid and sulfuric acid to effect the conversion of the elemental phosphorus content of the residues into mostly orthophosphoric acid and very little orthophosphorous acid with the relative ratios of orthophosphoric acid to orthophosphorous acid produced being dependent upon the weight ratio H.sub.2 SO.sub.4 :HNO.sub.3 employed in the processing. The reaction is conducted at the boiling point of the resulting aqueous reaction medium. Prior to the conversion to fertilizer products, the aqueous reaction product intermediate may be subjected to a solids separation step to remove insoluble salts of certain environmentally undesirable metals, such as, Pb, Cd, Ba, and Cr which are derived from phosphate rock via the dust component of phosphorus sludge.

摘要翻译： 用于氧化含水元素含磷残渣（淤泥）以产生含磷酸盐的浆料的方法，其适于随后与氨反应以产生含氮和磷的肥料产品。 它包括使含水元素的含磷残留物与浓硝酸和硫酸的某些特殊混合物反应，以使残余物的元素磷含量转化为大部分正磷酸和非常少的正磷酸，其中正磷酸与正磷酸的相对比例 产生取决于加工中使用的H 2 SO 4：HNO 3的重量比。 反应在所得含水反应介质的沸点下进行。 在转化成肥料产品之前，可以对含水反应产物中间体进行固体分离步骤以除去某些环境不合适的金属的不溶性盐，例如通过磷酸盐岩衍生自磷酸盐岩的Pb，Cd，Ba和Cr， 磷污泥的粉尘成分。

公开(公告)号：US4571435A

公开(公告)日：1986-02-18

申请号：US326981

申请日：1981-12-03

申请人： Robert J. Radel ,  Jack M. Sullivan

发明人： Robert J. Radel ,  Jack M. Sullivan

IPC分类号： C07C69/36 ,  C07C102/06 ,  C07C67/36

CPC分类号： C07C69/36

摘要： A process for the preparation of nitrogen fertilizers, especially oxamide, either indirectly or directly from oxalate esters, including the regeneration of the quinone oxidant utilized in the formation of the above esters. The process teaches preparation of oxamide, a potential slow-release nitrogen fertilizer via the oxidative carbonylation of alcohols with carbon monoxide in the presence of a catalytic amount of a platinum group metal salt and an optionally substituted quinone (substituted or unsubstituted 2,5-cyclohexadiene-1,4-dione) followed by ammoniation of the filtered reaction mixture at room temperature, or below. High yields of isolated oxamide were obtained by regulating the temperature and pressure during the oxidative carbonylation and maintaining essentially anhydrous conditions throughout the process. In addition, nearly quantitative yields of the hydroquinones (1,4-dihydroxybenzenes) are recovered for recycle along with the solvents, or for other commercial uses.

摘要翻译： 一种由草酸酯间接或直接制备氮肥，特别是草酰胺的方法，包括用于形成上述酯的醌氧化剂的再生。 该方法教导了在催化量的铂族金属盐和任选取代的醌（取代或未取代的2,5-环己二烯（取代或未取代的2,5-环己二烯）存在下，通过醇与一氧化碳的氧化羰基化制备草酰胺，一种潜在的缓释氮肥 -1,4-二酮），随后在室温或更低温度下对过滤的反应混合物进行氨化。 通过在氧化羰基化过程中调节温度和压力并在整个过程中保持基本上无水的条件，获得高产率的分离的氧杂酰胺。 此外，氢醌（1,4-二羟基苯）的几乎定量收率与溶剂一起回收再循环，或用于其它商业用途。

公开(公告)号：US4379939A

公开(公告)日：1983-04-12

申请号：US164418

申请日：1980-06-30

申请人： Robert J. Radel ,  Jack M. Sullivan

发明人： Robert J. Radel ,  Jack M. Sullivan

IPC分类号： C07C69/36 ,  C07C67/36

CPC分类号： C07C69/36

摘要： A process for the preparation of nitrogen fertilizers, especially oxamide, either indirectly, or directly from oxalate esters, including the regeneration of the quinone oxidant utilized in the formation of the above esters.Preparation of oxalate esters as potential intermediates for nitrogen fertilizers by the oxidative carbonylation of alcohols with carbon monoxide in the presence of a catalytic amount of a platinum group metal salt with or without a corresponding metal oxidant salt and an optionally substituted quinone (substituted or unsubstituted 2,5-cyclohexadiene-1,4-dione). High yields of isolated dialkyl oxalates are obtained by regulating temperature and carbon monoxide pressure and by maintaining essentially anhydrous conditions. In addition, high yields of the hydroquinones (1,4-dihydroxybenzenes) are recovered.

摘要翻译： 一种用于间接或直接从草酸酯制备氮肥，特别是草酰胺的方法，包括用于形成上述酯的醌氧化剂的再生。 通过在催化量的铂族金属盐的存在下，使用或不与相应的金属氧化剂盐和任选取代的醌（取代或未取代的2）进行醇的氧化羰基化，制备草酸酯作为氮肥的潜在中间体 ，5-环己二烯-1,4-二酮）。 通过调节温度和一氧化碳压力以及维持基本上无水的条件，可以获得高产率的分离出的草酸二烷基酯。 此外，回收高产率的氢醌（1,4-二羟基苯）。