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1.发明授权Photoactivatable two-stage protective groups for the synthesis of biopolymers 失效用于合成生物聚合物的可光活化的两阶段保护基团公开(公告)号：US07737089B2
公开(公告)日：2010-06-15
申请号：US10540396
申请日：2003-12-23
申请人： Ramon Güimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Güimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C40B70/00
CPC分类号： B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/18
摘要： The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
摘要翻译： 本发明涉及通过从承载两级保护基的保护合成结构单元逐步组装合成生物聚合物的方法。 两级保护基团通过第一照射步骤活化，并通过随后的化学处理步骤消除。 使用通过分子内三重态敏化剂显着加速激活过程或/具有荧光性质的光活化组分。 两级保护组特别可以在质量控制的框架内使用。
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公开(公告)号：US07355036B2
公开(公告)日：2008-04-08
申请号：US10482744
申请日：2002-07-03
IPC分类号： C07H21/04
摘要： The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step
摘要翻译： 本发明涉及通过从承载两阶段保护基团的保护合成结构单元逐渐分解来合成核酸的方法。 通过第一曝光步骤和随后的化学处理步骤将两级保护基分开
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公开(公告)号：US20060154253A1
公开(公告)日：2006-07-13
申请号：US10540517
申请日：2003-12-23
申请人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C12Q1/68 , C07F3/08 , C07D311/88 , C07D311/02
CPC分类号： C07C205/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07H15/26 , C07H19/00 , C07H21/00 , Y02P20/55
摘要： The present invention relates to a method for validating the synthesis of arrays, in particular of biopolymers, by step-by-step construction from protected and labeled synthesis building blocks.
摘要翻译： 本发明涉及通过从受保护和标记的合成结构单元的逐步构建来验证阵列的合成，特别是生物聚合物的合成方法。
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4.发明申请Photoactivatable two-stage protective groups for the synthesis of biopolymers 失效用于合成生物聚合物的可光活化的两阶段保护基团公开(公告)号：US20060111564A1
公开(公告)日：2006-05-25
申请号：US10540396
申请日：2003-12-23
申请人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C07H21/04
CPC分类号： B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/18
摘要： The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
摘要翻译： 本发明涉及通过从承载两级保护基的保护合成结构单元逐步组装合成生物聚合物的方法。 两级保护基团通过第一照射步骤活化，并通过随后的化学处理步骤消除。 使用通过分子内三重态敏化剂显着加速激活过程或/具有荧光性质的光活化组分。 两级保护组特别可以在质量控制的框架内使用。
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公开(公告)号：US09078929B2
公开(公告)日：2015-07-14
申请号：US13384789
申请日：2010-07-09
申请人： Armin Kuebelbeck , Gregor Larbig , Walter Mier , Barbro Beijer , Uwe Haberkorn
发明人： Armin Kuebelbeck , Gregor Larbig , Walter Mier , Barbro Beijer , Uwe Haberkorn
IPC分类号： A61K38/00 , A61P13/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04 , A61K47/48 , A61K49/08 , A61K51/04 , C07K7/06 , C07K14/00 , C07K7/08
CPC分类号： A61K47/48315 , A61K47/542 , A61K47/645 , A61K49/085 , A61K49/146 , A61K51/0497 , A61K51/088 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
摘要： The present invention relates to ε-polylysine conjugates, in particular conjugates of ε-polylysine with compounds carrying carboxyl groups, and to the preparation and use thereof for targeting of the kidney.
摘要翻译： 本发明涉及多聚赖氨酸缀合物，特别是＆amp;聚赖氨酸与携带羧基的化合物的缀合物，以及其用于靶向靶的制备和用途。
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公开(公告)号：US20120122788A1
公开(公告)日：2012-05-17
申请号：US13384789
申请日：2010-07-09
申请人： Armin Kuebelbeck , Gregor Larbig , Walter Mier , Barbro Beijer , Uwe Haberkorn
发明人： Armin Kuebelbeck , Gregor Larbig , Walter Mier , Barbro Beijer , Uwe Haberkorn
CPC分类号： A61K47/48315 , A61K47/542 , A61K47/645 , A61K49/085 , A61K49/146 , A61K51/0497 , A61K51/088 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
摘要： The present invention relates to ε-polylysine conjugates, in particular conjugates of ε-polylysine with compounds carrying carboxyl groups, and to the preparation and use thereof for targeting of the kidney.
摘要翻译： 本发明涉及多聚赖氨酸缀合物，特别是＆amp;聚赖氨酸与携带羧基的化合物的缀合物，以及其用于靶向靶的制备和用途。
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