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公开(公告)号：US20240159770A1
公开(公告)日：2024-05-16
申请号：US18420570
申请日：2024-01-23
申请人： Cowper Sciences Inc.
发明人： Matthew GREVING , David SMITH , Gaurav SAINI
IPC分类号： G01N33/68 , A61K39/395 , B01J19/00 , C07K16/32 , C12N15/10
CPC分类号： G01N33/6845 , A61K39/395 , A61K39/39558 , B01J19/0046 , C07K16/32 , C12N15/1055 , B01J2219/00675 , B01J2219/00711 , B01J2219/00725 , C07K2317/34 , C07K2317/92
摘要： Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.
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公开(公告)号：US11953464B2
公开(公告)日：2024-04-09
申请号：US17831424
申请日：2022-06-02
申请人： ILLUMINA, INC.
发明人： Dietrich Dehlinger , Ali Agah , Tracy Helen Fung , Emrah Kostem
IPC分类号： G01N27/414 , B01L3/00 , B01L7/00 , C12Q1/6869 , C12Q1/6874 , G01N21/64 , G01N21/76 , G06F18/24 , G06V10/75 , G16B30/00
CPC分类号： G01N27/4145 , B01L3/502715 , C12Q1/6874 , G01N21/6454 , G06F18/24 , G06V10/751 , B01J2219/00711 , B01J2219/00722 , B01L7/52 , B01L2200/147 , B01L2300/0636 , B01L2300/0645 , B01L2300/0663 , B01L2300/0893 , C12Q1/6869 , G01N2021/6432 , G01N2021/6441 , G01N2021/6471 , G01N2021/6478 , G01N2021/6482 , G01N21/76 , G01N21/763 , G01N2223/40 , G01N2223/413 , G05B2219/37563 , G16B30/00
摘要： A device for base calling is provided. The device includes a receptacle configured to hold a biosensor having a sample surface holding a plurality of clusters during a sequence of sampling events, an array of sensors sensing information from clusters disposed in corresponding pixel areas of the sample surface during the sampling events and generate sequences of pixel signals and a communication port configured to output the sequences of pixel signals. The device also includes a signal processor coupled to the communication port and configured to receive and process at least one pixel signal in the sequences of pixel signals that mixes light gathered from at least two clusters in a corresponding pixel area, and to base call each of the at least two clusters using the at least one pixel signal.
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公开(公告)号：US20190240636A1
公开(公告)日：2019-08-08
申请号：US16384678
申请日：2019-04-15
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00441 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00619 , B01J2219/00637 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722
摘要： Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.
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公开(公告)号：US09928869B2
公开(公告)日：2018-03-27
申请号：US15209127
申请日：2016-07-13
发明人： George M. Church
CPC分类号： G06F19/18 , B01J19/0046 , B01J2219/00529 , B01J2219/00547 , B01J2219/00572 , B01J2219/00596 , B01J2219/00608 , B01J2219/00675 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , C12Q1/68 , C12Q1/6874 , G06F5/08 , G06F19/00 , G11B7/241 , G11B7/245 , G11C7/00 , C12Q2563/179 , C12Q2563/185
摘要： A method of storing information using monomers such as nucleotides is provided including converting a format of information into a plurality of bit sequences of a bit stream with each having a corresponding bit barcode, converting the plurality of bit sequences to a plurality of corresponding oligonucleotide sequences using one bit per base encoding, synthesizing the plurality of corresponding oligonucleotide sequences on a substrate having a plurality of reaction locations, and storing the synthesized plurality of corresponding oligonucleotide sequences.
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公开(公告)号：US20170247755A1
公开(公告)日：2017-08-31
申请号：US15512441
申请日：2015-09-16
发明人： Mark W. Eshoo , John M. Clemens , Mark A. Hayden
CPC分类号： C12Q1/6869 , B01J2219/00317 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , C40B60/08 , G01N21/6428 , G01N21/6452 , G01N21/648 , C12Q2523/319 , C12Q2525/186
摘要： Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced).
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公开(公告)号：US20170218230A1
公开(公告)日：2017-08-03
申请号：US15515210
申请日：2015-10-02
发明人： Vincent Studer
CPC分类号： C09J5/02 , B01J19/00 , B01J19/08 , B01J2219/00596 , B01J2219/00711 , B82Y40/00 , C09J2205/31 , C09J2471/006 , C09J2483/006 , C40B50/18 , G01N33/54353
摘要： Process for printing an adhesive pattern on a polymer brush extending at the surface of a support (1), forming a nanometric anti-fouling layer (2), the process comprising the following steps:—placing the layer (2) in contact with a first aqueous solution (4) containing a benzophenone,—then illuminating the layer with radiation (3) at a wavelength within the absorption spectrum of benzophenone, according to the pattern and according to a surface energy.
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7.发明申请ASSEMBLING APPARATUS AND ASSEMBLING METHOD, APPARATUS FOR MANUFACTURING MICROSCOPIC OBJECT ASSEMBLY STRUCTURE, APPARATUS FOR ASSEMBLING AND REMOVING MICROORGANISM, APPARATUS FOR DETECTING DETECTION TARGET SUBSTANCE, APPARATUS FOR SEPARATING SEPARATION TARGET SUBSTANCE, AND APPARATUS FOR INTRODUCING INTRODUCTION TARGET SUBSTANCE 审中-公开组装装置和组装方法，用于制造微观物体组装结构的装置，用于组装和移除微生物的装置，用于检测目标物质的装置，用于分离分离目标物质的装置，以及用于介绍引物目标的装置公开(公告)号：US20170074760A1
公开(公告)日：2017-03-16
申请号：US15308895
申请日：2015-05-08
CPC分类号： G01N1/44 , B01J19/00 , B01J19/0046 , B01J2219/00441 , B01J2219/00468 , B01J2219/00711 , C12M1/26 , C12M1/34 , C12M35/02 , G01N15/00 , G01N15/14
摘要： An assembling apparatus assembles beads different in particle size from each other. The assembling apparatus includes a substrate and a photothermal light source. The substrate is constructed to be able to hold a sample in which the beads are dispersed. The photothermal light source irradiates the substrate or the sample with laser beams to thereby produce a temperature difference in the sample.
摘要翻译： 组装装置将不同粒径的珠子组装在一起。 组装装置包括基板和光热光源。 衬底被构造成能够容纳其中分散有珠粒的样品。 光热光源用激光束照射基板或样品，从而在样品中产生温度差。
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公开(公告)号：US20170017436A1
公开(公告)日：2017-01-19
申请号：US15209127
申请日：2016-07-13
发明人： George M. Church
CPC分类号： G06F19/18 , B01J19/0046 , B01J2219/00529 , B01J2219/00547 , B01J2219/00572 , B01J2219/00596 , B01J2219/00608 , B01J2219/00675 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , C12Q1/68 , C12Q1/6874 , G06F5/08 , G06F19/00 , G11B7/241 , G11B7/245 , G11C7/00 , C12Q2563/179 , C12Q2563/185
摘要： A method of storing information using monomers such as nucleotides is provided including converting a format of information into a plurality of bit sequences of a bit stream with each having a corresponding bit barcode, converting the plurality of bit sequences to a plurality of corresponding oligonucleotide sequences using one bit per base encoding, synthesizing the plurality of corresponding oligonucleotide sequences on a substrate having a plurality of reaction locations, and storing the synthesized plurality of corresponding oligonucleotide sequences.
摘要翻译： 提供了使用诸如核苷酸的单体存储信息的方法，包括将信息格式转换成具有相应位条形码的位流的多个比特序列，将多个比特序列转换成多个相应寡核苷酸序列，使用 每个碱基编码一位，在具有多个反应位置的底物上合成多个相应的寡核苷酸序列，并存储合成的多个相应的寡核苷酸序列。
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公开(公告)号：US20160179008A1
公开(公告)日：2016-06-23
申请号：US14908836
申请日：2014-07-31
CPC分类号： G03F7/26 , B01J2219/00637 , B01J2219/00711 , B01J2219/00722 , B82Y40/00 , G03F7/0002 , G03F7/16 , G03F7/2002
摘要： This disclosure relates to DNA double-write/double binding identity, and the design and use of DNA double-write materials and methods in processes and systems for macro, micro, and nano-photolithography and self-assembly processes for carrying out two and three dimensional nanofabrication.
摘要翻译： 本公开涉及DNA双写/双重结合同一性，以及DNA双写材料的设计和使用以及用于宏观，微观和纳米光刻和自组装过程的方法和系统中用于进行两个和三个 立体纳米制造。
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公开(公告)号：US20150336071A1
公开(公告)日：2015-11-26
申请号：US14812951
申请日：2015-07-29
发明人： David A. Weitz , Jeremy Agresti
CPC分类号： C12Q1/6876 , B01J13/04 , B01J19/0046 , B01J2219/00599 , B01J2219/00709 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C12Q1/6874
摘要： The present invention is generally related to systems and methods for producing a plurality of droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, the fluidic droplets may be rigidified to form rigidified droplets (e.g., gel droplets). In certain embodiments, the droplets may undergo a phase change (e.g., from rigidified droplets to fluidized droplets), as discussed more herein. In some cases, a species may be added internally to a droplet by exposing the droplet to a fluid comprising a plurality of species.
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