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公开(公告)号:US20060223876A1
公开(公告)日:2006-10-05
申请号:US11278299
申请日:2006-03-31
申请人: Randy Burd , Luigi Lenaz , Shanta Chawla , Guru Reddy , Adam Dicker
发明人: Randy Burd , Luigi Lenaz , Shanta Chawla , Guru Reddy , Adam Dicker
IPC分类号: A61K31/404
CPC分类号: A61K41/0038 , A61K31/404
摘要: This invention generally relates to Indoloquinone caused tumor radiation therapy sensitization. More specifically, this invention relates to the discovery of indoloquinones as a radiation sensitizer (radiation therapy adjuvant) due to its ability to selectively target hypoxic cells and to damage the DNA of these hypoxic cells. Indoloquinones do so with minimal normal cell and tissue toxicity.
摘要翻译: 本发明一般涉及吲哚醌引起的肿瘤放射治疗敏化。 更具体地,本发明涉及由于其选择性靶向缺氧细胞并损害这些缺氧细胞的DNA的能力,发现吲哚醌作为辐射敏化剂(放射治疗佐剂)。 吲哚醌具有最小的正常细胞和组织毒性。
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公开(公告)号:US20050196340A1
公开(公告)日:2005-09-08
申请号:US10998881
申请日:2004-11-29
CPC分类号: A61K38/179 , A61K41/00 , A61K2300/00
摘要: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, in combination with radiation therapy and/or a therapeutic radiopharmaceutical.
摘要翻译: 在有需要的受试者中治疗癌症和/或减少或抑制肿瘤生长的方法,包括与放射治疗和/或治疗放射性药物组合施用包含血管内皮细胞生长因子(VEGF)拮抗剂的药物组合物。
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公开(公告)号:US20050112061A1
公开(公告)日:2005-05-26
申请号:US10909011
申请日:2004-07-30
CPC分类号: A61K41/00 , A61K38/179 , A61K2300/00
摘要: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) trap, in combination with radiation therapy and/or a therapeutic radiopharmaceutical.
摘要翻译: 在有需要的受试者中治疗癌症和/或减少或抑制肿瘤生长的方法,包括与放射治疗和/或治疗放射性药物组合施用包含血管内皮细胞生长因子(VEGF)陷阱的药物组合物。
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