公开(公告)号：US20110176714A1

公开(公告)日：2011-07-21

申请号：US12970184

申请日：2010-12-16

申请人： Rares Salomir ,  Magalie Viallon ,  Joerg Roland ,  Patrick Gross

发明人： Rares Salomir ,  Magalie Viallon ,  Joerg Roland ,  Patrick Gross

IPC分类号： G06K9/00

CPC分类号： G01R33/4804 ,  G01R33/56509

摘要： In a method to determine a background phase in phase values of a phase image data set that is acquired from an examination subject, wherein the background phase is determined in a partial region of the phase image data set, the phase image data set of the examination subject is acquired, and a substantially closed, planar contour is established in the phase image data set around the partial region, the planar contour having a contour area with a width of at least one pixel of the phase image data set. The phase values in the partial region are determined with the assumption that the spatial curve of the background phase is a harmonic or quasi-harmonic function, the phase values of the pixels in the partial region being determined based on the phase values in the planar contour.

摘要翻译： 在确定从检查对象获取的相位图像数据集的相位值的背景相位的方法中，其中在相位图像数据集的部分区域中确定背景相位，检查的相位图像数据集 获取对象，并且在围绕该部分区域设置的相位图像数据中建立基本封闭的平面轮廓，该平面轮廓具有具有相位图像数据集的至少一个像素的宽度的轮廓区域。 通过假设背景相位的空间曲线是谐波或准谐波函数来确定部分区域中的相位值，基于平面轮廓中的相位值来确定部分区域中的像素的相位值 。

公开(公告)号：US08630471B2

公开(公告)日：2014-01-14

申请号：US12970184

申请日：2010-12-16

申请人： Rares Salomir ,  Magalie Viallon ,  Joerg Roland ,  Patrick Gross

发明人： Rares Salomir ,  Magalie Viallon ,  Joerg Roland ,  Patrick Gross

IPC分类号： G06K9/00

CPC分类号： G01R33/4804 ,  G01R33/56509

摘要： In a method to determine a background phase in phase values of a phase image data set that is acquired from an examination subject, wherein the background phase is determined in a partial region of the phase image data set, the phase image data set of the examination subject is acquired, and a substantially closed, planar contour is established in the phase image data set around the partial region, the planar contour having a contour area with a width of at least one pixel of the phase image data set. The phase values in the partial region are determined with the assumption that the spatial curve of the background phase is a harmonic or quasi-harmonic function, the phase values of the pixels in the partial region being determined based on the phase values in the planar contour.

摘要翻译： 在确定从检查对象获取的相位图像数据集的相位值的背景相位的方法中，其中在相位图像数据集的部分区域中确定背景相位，检查的相位图像数据集 获取对象，并且在围绕该部分区域设置的相位图像数据中建立基本封闭的平面轮廓，该平面轮廓具有具有相位图像数据集的至少一个像素的宽度的轮廓区域。 通过假设背景相位的空间曲线是谐波或准谐波函数来确定部分区域中的相位值，基于平面轮廓中的相位值来确定部分区域中的像素的相位值 。

公开(公告)号：US20120041306A1

公开(公告)日：2012-02-16

申请号：US12855157

申请日：2010-08-12

申请人： Patrick Gross ,  Rares Salomir ,  Sylvain Terraz ,  Magalie Viallon ,  Anke Weissenborn

发明人： Patrick Gross ,  Rares Salomir ,  Sylvain Terraz ,  Magalie Viallon ,  Anke Weissenborn

IPC分类号： A61M25/00 ,  A61N5/00 ,  A61N7/00 ,  A61B6/00 ,  A61N1/00

CPC分类号： A61K41/0047 ,  A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B6/481 ,  A61B2018/1425 ,  A61B2018/1869 ,  A61B2018/2005 ,  A61B2090/3933 ,  A61B2090/3954 ,  A61K41/00 ,  A61K49/0002 ,  A61M31/005 ,  A61N7/02

摘要： In a method and system for administering a dispersible medical agent to a subject, a volume of medical agent is delivered in vivo to a subject in a substantially non-dispersed state, at a localized site in tissue of the subject. Contemporaneously with administration of the medical agent to the localized site, energy from an energy source is introduced into only adjacent tissue surrounding the localized site. The energy produces a cellular modification of the adjacent tissue that makes the adjacent tissue substantially impermeable to passage of the medical agent therethrough, so the medical agent is encapsulated and is prevented from dispersing into tissue outside of the encapsulation.

摘要翻译： 在用于向受试者施用可分散医药的方法和系统中，在受试者的组织中的局部位置处，将体积的医用试剂在体内以基本上非分散状态递送至受试者。 同时将医疗剂施用于局部位置，来自能量源的能量被引入仅在局部位点周围的相邻组织。 能量产生相邻组织的细胞改性，使相邻组织基本上不透液体通过药剂，因此药剂被包封并被防止分散到包封外部的组织中。

公开(公告)号：US20120016271A1

公开(公告)日：2012-01-19

申请号：US12835996

申请日：2010-07-14

申请人： Rares Salomir ,  Magalie Viallon

发明人： Rares Salomir ,  Magalie Viallon

IPC分类号： A61N7/00 ,  C09K3/00

CPC分类号： A61N7/02 ,  A61B2018/00011 ,  A61B2090/374 ,  A61K41/0028

摘要： In order to reduce reflection and heating of a high intensity focused ultrasound (HIFU) beam following a region of interest in tissue to which an HIFU beam was administered, at least two layers of aquasonic gel are applied at a tissue/air interface following the region of interest and the focus in a direction of propagation of the HIFU beam. A first of the two aquasonic gel layers is a foamed aquasonic gel layer, and a second of the two layers is substantially bubble-free aquasonic gel. The layer of foamed aquasonic gel is placed directly adjacent the tissue/air interface, and the layer of substantially bubble-free aquasonic gel is placed over the layer of foamed aquasonic gel, at a side thereof facing away from the tissue/air interface.

摘要翻译： 为了减少在施用HIFU束的组织中感兴趣的区域之后的高强度聚焦超声（HIFU）光束的反射和加热，在区域之后的组织/空气界面处施加至少两层水凝胶 感兴趣的并且在HIFU光束的传播方向上的焦点。 两个超声波凝胶层中的第一层是发泡的超声波凝胶层，两层中的第二层是基本上无气泡的水凝胶。 泡沫水凝胶层被直接放置在组织/空气界面附近，并且基本上无气泡的水溶胶凝胶层被放置在发泡的含水凝胶层的一侧，其背离组织/空气界面。

公开(公告)号：US09375588B2

公开(公告)日：2016-06-28

申请号：US13303872

申请日：2011-11-23

申请人： Rares Salomir ,  Magalie Viallon ,  Lorena Petrusca ,  Vincent Auboiroux ,  Thomas Goget ,  Maria Isabel Vargas Gomez

发明人： Rares Salomir ,  Magalie Viallon ,  Lorena Petrusca ,  Vincent Auboiroux ,  Thomas Goget ,  Maria Isabel Vargas Gomez

IPC分类号： A61B5/05 ,  A61N7/02 ,  A61B19/00

CPC分类号： A61N7/02 ,  A61B90/37 ,  A61B2034/2065 ,  A61B2090/0436 ,  A61B2090/0445 ,  A61B2090/0454 ,  A61B2090/374

摘要： In order to decrease collateral heating of ribs and tissue surrounding the ribs in a patient during high-intensity focused ultrasound (HIFU) therapy, shielding material may be positioned on or adjacent to an external surface of the patient and aligned with ribs to be protected using a magnetic resonance imaging (MRI) system. The MRI system may be used to image the shielding material and the ribs to be protected, and an error of alignment between the ribs to be protected and the shielding material may be determined based on the images. The shielding or masking material may be repositioned based on the determined error of alignment, images of the shielding material and the ribs to be protected may be reacquired, and the error of alignment may be redetermined based on the reacquired images until the shielding material is aligned with the ribs to be protected.

摘要翻译： 为了减少在高强度聚焦超声（HIFU）治疗期间患者周围的肋骨和组织的侧支加热，屏蔽材料可以被定位在患者的外表面上或邻近患者的外表面上并且与要被保护的肋条对准 磁共振成像（MRI）系统。 可以使用MRI系统对屏蔽材料和待保护的肋进行成像，并且可以基于图像确定待保护的肋之间的对准误差和屏蔽材料。 可以基于确定的对准误差重新定位屏蔽或掩蔽材料，可以重新获取屏蔽材料和待保护的肋的图像，并且可以基于重新获取的图像重新确定对准的误差，直到屏蔽材料对准 肋骨被保护。

公开(公告)号：US20130274590A1

公开(公告)日：2013-10-17

申请号：US13448630

申请日：2012-04-17

申请人： Vincent Auboiroux ,  Magalie Viallon ,  Lorena Petrusca ,  Rares Salomir

发明人： Vincent Auboiroux ,  Magalie Viallon ,  Lorena Petrusca ,  Rares Salomir

IPC分类号： A61B5/055

CPC分类号： A61N7/02 ,  A61B34/10 ,  A61B90/30 ,  A61B90/361 ,  A61B2090/0436 ,  A61B2090/309 ,  A61B2090/3612 ,  A61B2090/374 ,  A61N2007/0086

摘要： In a method and magnetic resonance (MR) apparatus for implementing an MR-guided procedure, an MR-compatible digital camera is placed in the patient receiving opening of the MR data acquisition unit that is operated to acquire MR data for reconstructing images that are used to guide the MR-guided intervention. The digital camera is operated to obtain digital images of the exterior of the patient, from which motion of the patient is detectable. The images are analyzed in a processor to identify therefrom the motion of the patient and the result of the analysis is represented as a processor output that is used to control the timing, with respect to the motion of the examination subject, of the occurrence of at least one event in the MR-guided procedure. One important application is respiratory gating/triggering of HIFU sonication for the treatment of moving organs.

摘要翻译： 在用于实施MR引导过程的方法和磁共振（MR）装置中，MR兼容数字照相机被放置在MR数据获取单元的患者接收开口中，该数据获取单元被操作以获取用于重建所使用的图像的MR数据 指导MR指导干预。 数字照相机被操作以获得患者外部的数字图像，患者的运动可从该数字图像中检测出。 在处理器中分析图像以从其中识别患者的运动，并且分析结果被表示为用于控制关于检查对象的运动的时间的处理器输出 在MR指导程序中至少有一个事件。 一个重要的应用是HIFU超声处理移动器官的呼吸门控/触发。

公开(公告)号：US20120108976A1

公开(公告)日：2012-05-03

申请号：US12916731

申请日：2010-11-01

申请人： Rares Salomir ,  Magalie Viallon

发明人： Rares Salomir ,  Magalie Viallon

IPC分类号： A61B8/00

CPC分类号： A61B8/4281 ,  A61B8/4455 ,  A61B8/485 ,  A61B8/54 ,  A61B2090/374 ,  A61N7/02

摘要： An ultrasound transducer for use in a magnetic resonance system is provided with an RF shield formed of electrically conductive material and having an interior cavity configured to receive the ultrasound transducer therein. The RF shield substantially precludes coupling between the ultrasound transducer, and any coupling medium that is employed, and the transmission and reception coils of the magnetic resonance system.

摘要翻译： 用于磁共振系统的超声换能器设置有由导电材料形成的RF屏蔽，并且具有被配置为在其中接收超声换能器的内腔。 RF屏蔽件基本上排除了超声换能器和所采用的任何耦合介质之间的耦合以及磁共振系统的发射和接收线圈。

公开(公告)号：US20140266189A1

公开(公告)日：2014-09-18

申请号：US13836033

申请日：2013-03-15

申请人： Rares Salomir ,  Magalie Viallon ,  Lorena Petrusca

发明人： Rares Salomir ,  Magalie Viallon ,  Lorena Petrusca

IPC分类号： G01R33/422

CPC分类号： G01R33/422 ,  A61B2090/374 ,  A61N7/02 ,  G01R33/4814

摘要： An RF active device, immersed in liquid medium, for use in a magnetic resonance system is provided with an RF shield formed of electrically conductive material and having an interior cavity configured to receive the RF active device therein. The RF shield substantially precludes coupling between the active device, and any coupling medium that is employed, and the transmission and reception coils of the magnetic resonance system.

摘要翻译： 浸没在用于磁共振系统的液体介质中的RF有源器件设置有由导电材料形成并具有被配置为在其中接收RF有源器件的内部空腔的RF屏蔽。 RF屏蔽件基本上排除了有源器件和所采用的任何耦合介质之间的耦合以及磁共振系统的发送和接收线圈。

公开(公告)号：US08583211B2

公开(公告)日：2013-11-12

申请号：US13206867

申请日：2011-08-10

申请人： Rares Salomir ,  Magalie Viallon

发明人： Rares Salomir ,  Magalie Viallon

IPC分类号： A61B5/055

CPC分类号： A61N7/02 ,  A61B5/015 ,  A61N2007/027 ,  G05D23/1919 ,  G05D23/27

摘要： In a method for temperature control in MR-guided administration of ultrasound, ultrasound therapy is administered to a patient at an in vivo site by emitting focused ultrasound into the site at multiple foci with a multi-focus ultrasound therapy device. The temperature is monitored in a localized region of an examination subject in which the site is located during the therapy in real-time by MR thermometry. From the MR thermometry, characteristics of the temperature distribution in the monitored region of the examination subject are automatically identified. Temperature control is implemented by regulating the energy output of the ultrasound therapy device, according to a rapidly converging master equation.

摘要翻译： 在用于MR引导施用超声的温度控制方法中，通过用多焦点超声治疗装置在多个焦点处发射聚焦超声波到该位置，向体内部位的患者施用超声治疗。 通过MR测温法实时地在治疗期间位于检查对象的局部区域中监测温度。 从MR测温法，自动识别检查对象的被监测区域的温度分布特征。 根据快速收敛的主方程，通过调节超声治疗装置的能量输出实现温度控制。

公开(公告)号：US20130041249A1

公开(公告)日：2013-02-14

申请号：US13206867

申请日：2011-08-10

申请人： Rares Salomir ,  Magalie Viallon

发明人： Rares Salomir ,  Magalie Viallon

IPC分类号： A61N7/00 ,  A61B5/01 ,  A61B5/055

CPC分类号： A61N7/02 ,  A61B5/015 ,  A61N2007/027 ,  G05D23/1919 ,  G05D23/27

摘要： In a method for temperature control in MR-guided administration of ultrasound, ultrasound therapy is administered to a patient at an in vivo site by emitting focused ultrasound into the site at multiple foci with a multi-focus ultrasound therapy device. The temperature is monitored in a localized region of an examination subject in which the site is located firing said therapy in real-time by MR thermometry. From the MR thermometry, characteristics of the temperature distribution in the monitored region of the examination subject are automatically identified. Temperature control is implemented by regulating the energy output of the ultrasound therapy device, according to a rapidly converging master equation.

摘要翻译： 在用于MR引导施用超声的温度控制方法中，通过用多焦点超声治疗装置在多个焦点处发射聚焦超声波到该位置，向体内部位的患者施用超声治疗。 在检查对象的局部区域中监测温度，其中所述部位通过MR测温法实时地进行所述治疗。 从MR测温法，自动识别检查对象的被监测区域的温度分布特征。 根据快速收敛的主方程，通过调节超声治疗装置的能量输出实现温度控制。