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1.发明授权Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR 有权基于用于酪氨酸激酶受体的工程化蛋白质的靶向治疗剂，包括IGF-1R公开(公告)号：US08470332B2
公开(公告)日：2013-06-25
申请号：US12312725
申请日：2007-11-21
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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2.发明申请TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR 有权基于酪氨酸激酶受体的工程化蛋白质的针对性治疗剂，包括IGF-IR公开(公告)号：US20100121033A1
公开(公告)日：2010-05-13
申请号：US12312725
申请日：2007-11-21
IPC分类号： C07K14/765 , C07K14/00 , C07K16/00 , C07K14/79
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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