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57 条记录 (耗时 0.024 秒)

    Biologically active peptides and compositions, their use
    6.
    发明授权
    Biologically active peptides and compositions, their use 失效
    生物活性肽和组合物，其用途

    公开(公告)号：US6153590A

    公开(公告)日：2000-11-28

    申请号：US930584

    申请日：1998-02-02

    申请人： Raymond Andersen ,  John Coleman ,  Dilip De Silva ,  Fangming Kong ,  Edward Piers ,  Debra Wallace ,  Michel Roberge ,  Teresa Allen

    发明人： Raymond Andersen ,  John Coleman ,  Dilip De Silva ,  Fangming Kong ,  Edward Piers ,  Debra Wallace ,  Michel Roberge ,  Teresa Allen

    IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K5/02 ,  C07K5/027 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083

    CPC分类号： C07K5/0205 ,  C07K5/0827 ,  A61K38/00

    摘要： Compounds of general formula I ##STR1## wherein: R.sub.1 and R.sub.70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R.sub.2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R.sub.6 represents a group --CH.dbd. as hereinafter described; R.sub.73 represents a hydrogen atom or an optional substituent or is absent when R.sub.6 represents a methylene group or a group --CH.dbd. as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R.sub.3 represents a hydrogen atom, or an optionally substituted alkyl group; R.sub.74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.75 represents an optionally substituted alkyl group; and i) R.sub.6 and R.sub.71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R.sub.72 represents a hydrogen atom; or ii) R.sub.71 represents a hydrogen atom or an optionally susbtituted alkyl or acyl group and R.sub.72 represents a hydrogen atom or R.sub.71 and R.sub.72 are joined together such that a double bond is formed between the carbon atoms to which they are attached; and R.sub.6 represents an optionally substituted methylene group bonded to the indole moiety thereby forming a tricyclic moiety; or R.sub.6 represents an optionally substituted group --CH.dbd. bonded to the indole moiety thereby to form an aromatic tricyclic moiety; for use in therapy and as antimitotic reagents are described.

    摘要翻译： PCT No.PCT / GB96 / 00942 Sec。 371日期1998年2月2日 102（e）1998年2月2日PCT 1996年4月22日PCT PCT。 出版物WO96 / 33211 日期：1996年10月24日通式I化合物其中：R 1和R 70独立地表示氢原子或任选取代的烷基或酰基; R2表示氢原子或任选取代的烷基或酰基，或当R6表示基团-CH =时不存在，如下所述; 当R 6表示亚甲基或-CH =如下所述时，R 73表示氢原子或任选的取代基或不存在; Y表示任选的取代基; n表示0,1,2,3或4; R3表示氢原子或任选取代的烷基; R 74表示氢原子，羟基或任选取代的烷基或酰基; R7表示氢原子或烷基; R75表示任选取代的烷基; 和i）R 6和R 71独立地表示氢原子或任选取代的烷基或酰基; R 72表示氢原子; 或ii）R 71表示氢原子或任选取代的烷基或酰基，R 72表示氢原子或R 71和R 72连接在一起，使得在它们所连接的碳原子之间形成双键; 并且R 6表示与吲哚部分键合的任选取代的亚甲基，从而形成三环部分; 或R6表示与吲哚部分键合的任选取代的基团-CH =，从而形成芳族三环部分; 用于治疗和用作抗有益剂的试剂。

    Intelligent heterogeneous, mobile, Ad-Hoc communication network
    9.
    发明授权
    Intelligent heterogeneous, mobile, Ad-Hoc communication network 有权
    智能异构，移动，Ad-Hoc通信网络

    公开(公告)号：US08818397B2

    公开(公告)日：2014-08-26

    申请号：US12263467

    申请日：2008-11-01

    申请人： Penny Shikowitz ,  John Coleman ,  James Manning

    发明人： Penny Shikowitz ,  John Coleman ,  James Manning

    IPC分类号： H04L12/26

    CPC分类号： H04W84/18 ,  G01D21/00 ,  H04L67/12 ,  H04L67/125 ,  H04W4/02

    摘要： The present invention relates to a Mobile Ad Hoc Network that possesses sufficient intelligence to handle a collection of devices that differ in terms of features either inherent to the device or the environment in which they operate. The different features inherent to the device may consist of different hardware and software technologies (e.g., combination of RF for transmission ability, processing ability, power supply, and interfaces). The different features of the environment may consist of any telemetry data measuring the state of the environment, as well as information regarding the MANet such as the density of devices in the vicinity of a device. Various applications are considered.

    摘要翻译： 本发明涉及一种移动Ad Hoc网络，其具有足够的智能来处理在设备固有的特征或其操作环境方面不同的设备的集合。 设备固有的不同特征可以由不同的硬件和软件技术（例如，用于传输能力，处理能力，电源和接口的RF的组合）组成。 环境的不同特征可以包括测量环境状态的任何遥测数据，以及关于MANet的信息，例如设备附近的设备的密度。 考虑各种应用。

    Reel
    10.
    发明申请
    Reel 有权
    卷轴

    公开(公告)号：US20110253830A1

    公开(公告)日：2011-10-20

    申请号：US12944359

    申请日：2010-11-11

    申请人： Richard P. Witwer ,  Seth Galewyrick ,  Andrew Weiman ,  John Coleman

    发明人： Richard P. Witwer ,  Seth Galewyrick ,  Andrew Weiman ,  John Coleman

    IPC分类号： B65H75/18 ,  B65H75/14

    CPC分类号： B65H75/22 ,  B65H2701/51526

    摘要： A reel comprises a cylindrical core composed of two complementary arcuate core segments, a pair of flanges disposed respectively at axially spaced opposite ends of the core, and a pair of rings for connecting the core to the flanges. The rings are fixed respectively to facing inner sides of the flanges. Cooperating slots and tongues on the rings and core elements prevent the flanges from moving relative to the core in the direction of the axis of the core. The tongues enter the slots when the core segments are brought together. Resiliently bendable locking arms protrude radially inward from both ends of each core segment, and each locking arm is engageable by a snap fit with one of the rings when the core segments are brought together. Access openings in the flanges adjacent each of the locking arms allow access to the locking arms for disengagement from the rings.

    摘要翻译： 卷轴包括由两个互补的弧形芯段组成的圆柱形芯，分别设置在芯的轴向间隔开的相对端处的一对凸缘以及用于将芯连接到凸缘的一对环。 环分别固定在法兰的面向内侧。 环和芯元件上的合作槽和舌片防止凸缘沿着芯的轴线方向相对于芯移动。 当核心片段合在一起时，舌片进入插槽。 弹性可弯曲的锁定臂从每个芯段的两端径向向内突出，并且当芯段被带到一起时，每个锁定臂可通过与其中一个环的卡扣配合来接合。 靠近每个锁定臂的凸缘中的进入开口允许进入锁定臂以脱离环。