公开(公告)号：US06436425B1

公开(公告)日：2002-08-20

申请号：US09499887

申请日：2000-02-08

申请人： Raymond L. Henry ,  Lorraine E. Reeve ,  Stephen G. Flore ,  Frederick J. Foley

发明人： Raymond L. Henry ,  Lorraine E. Reeve ,  Stephen G. Flore ,  Frederick J. Foley

IPC分类号： A61P4100

CPC分类号： A61K9/0014 ,  A61K9/1075 ,  A61K31/522 ,  A61K31/765 ,  A61K31/77 ,  A61K31/785 ,  A61K47/10 ,  A61K47/18 ,  A61L31/06 ,  C08L71/02

摘要： Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.

摘要翻译： 公开了非胶凝聚氧化烯组合物及其用于抑制哺乳动物中外科粘连形成/重组的方法。 有用的非胶凝组合物优选包含具有或不具有治疗剂的所需浓度的聚氧化烯嵌段共聚物。 当与掺入的药物一起使用时，非胶凝组合物用作提供治疗剂持续或延长释放的载体。

公开(公告)号：US06663622B1

公开(公告)日：2003-12-16

申请号：US09649998

申请日：2000-08-28

申请人： Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Thomas G. Adelman ,  Michael F. Hoey

发明人： Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Thomas G. Adelman ,  Michael F. Hoey

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B2017/003 ,  A61B2017/0243 ,  A61B2017/22067 ,  A61B2017/320052 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00875 ,  A61B2018/1475

摘要： Devices and a method are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. A device can be configured to operate as a template that adheres to the tissue surface, and allows the surgeon to more easily sever the conduction path to form a lesion in a desired location. In particular, the template can be used to guide the surgeon's use of a surgical instrument along a desired ablation path. In some case, the template may incorporate hardware that structurally supports the instrument for travel along the ablation path. A surgical instrument such as an ablation probe, e.g., radio frequency, laser, ultrasonic, microwave, thermal, chemical, mechanical, or cryogenic ablation probe, may be used to sever the conduction paths. Measurements made substantially contemporaneously with the conduction path ablation operation may be used to evaluate whether the desired degree of ablation has been achieved. The device may also incorporate feedback to compare the desired degree of conduction path ablation with the measured degree, and may deactivate the surgical instrument when the desired degree has been achieved. In some cases, the template device can be configured to provide local stabilization of organ tissue, particularly for a moving organ such as a beating heart. In other cases, the template device may provide little or no stabilization, but provide a guide structure for placement of the ablation probe in the same frame of motion as the moving tissue. Also, for some applications, the template device may be arranged to facilitate application of other therapeutic devices, such as diagnostic probes, pacing leads, and drug delivery devices, to the surface of a moving organ.

公开(公告)号：US06558314B1

公开(公告)日：2003-05-06

申请号：US09692524

申请日：2000-10-19

申请人： Thomas G. Adelman ,  Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Michael F. Hoey

发明人： Thomas G. Adelman ,  Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Michael F. Hoey

IPC分类号： A61F200

CPC分类号： A61B17/02 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00291

摘要： Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.

摘要翻译： 操纵和稳定器官组织（如心脏组织）的装置和方法。 具有不同尺寸，形状和构造的装置通常包括密封构件，该密封构件具有带有壁的腔室和裙部状构件，其从室壁向外延伸以与器官的表面接触。 裙状构件基本上柔顺和粘性，从而促进与器官表面的粘附。 通过机械或液压施加真空压力可以增强装置对组织的粘附性。 该方法描述了操作的步骤，包括移动，提升，固定，转动和重新定向，器官组织。 其他方法描述了操纵心脏的步骤。

公开(公告)号：US06641604B1

公开(公告)日：2003-11-04

申请号：US09663917

申请日：2000-09-18

申请人： Thomas G. Adelman ,  Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Michael F. Hoey

发明人： Thomas G. Adelman ,  Frederick J. Foley ,  James S. Sharrow ,  Lorraine E. Reeve ,  Michael F. Hoey

IPC分类号： A61F200

CPC分类号： A61B17/02 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00291

摘要： Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.

公开(公告)号：US06951533B2

公开(公告)日：2005-10-04

申请号：US10067097

申请日：2002-02-04

申请人： Frederick J. Foley

发明人： Frederick J. Foley

IPC分类号： A61B17/00 ,  A61B17/02 ,  A61B17/30 ,  A61F2/00

CPC分类号： A61B17/02 ,  A61B2017/00287 ,  A61B2017/00544 ,  A61B2017/0243 ,  A61B2017/308

摘要： The invention provides techniques for securely engaging an organ, such as a beating heart, with a manipulating device. A bag-like device may be deployed around a substantial volume of the organ and the manipulating device. In one embodiment, the bag-like device may be net-like, including one or more mesh apertures. Once deployed, the bag-like device cooperates with the manipulating device when the organ is manipulated and reduces the risk that the organ will be inadvertently released or dropped.

摘要翻译： 本发明提供了用于将器官（例如跳动心脏）与操纵装置牢固接合的技术。 袋状装置可以围绕器官和操纵装置的大体积部署。 在一个实施例中，袋状装置可以是网状的，包括一个或多个网孔。 一旦被部署，当器官被操纵时，袋状装置与操纵装置配合，并降低器官不经意地释放或掉落的风险。

公开(公告)号：US6139538A

公开(公告)日：2000-10-31

申请号：US943966

申请日：1997-10-06

申请人： William C. Houghton ,  Keith R. Hildebrand ,  Martin B. Finkelstein ,  Frederick J. Foley

发明人： William C. Houghton ,  Keith R. Hildebrand ,  Martin B. Finkelstein ,  Frederick J. Foley

IPC分类号： A61N1/05 ,  A61N1/30 ,  A61N1/32 ,  A61M31/00

CPC分类号： A61N1/0524 ,  A61N1/306 ,  A61N1/325 ,  A61M2210/14

摘要： An apparatus for iontophoretically delivering an agent to a patient having a uterus and a cervix. The apparatus comprises a probe sized to fit within the cervical canal. A cervical cap has an inner surface. The probe projects from the inner surface. A first electrode has a first portion operably connected to the cervical cap and a second portion operably connected to the probe. The first electrode is configured to be electrically connected to a power supply. A second electrode is configured to be electrically connected to the power supply. A reservoir having a first portion operably connected to the cervical cap and a second portion operably connected to the probe.

摘要翻译： 用于将药剂离子电渗输送到具有子宫和子宫颈的患者的装置。 该装置包括尺寸适合于颈部管内的探针。 宫颈帽具有内表面。 探头从内表面突出。 第一电极具有可操作地连接到宫颈帽的第一部分和可操作地连接到探针的第二部分。 第一电极被配置为电连接到电源。 第二电极被配置为电连接到电源。 具有可操作地连接到颈帽的第一部分和可操作地连接到探针的第二部分的储存器。

公开(公告)号：US06773418B1

公开(公告)日：2004-08-10

申请号：US09377012

申请日：1999-08-18

申请人： James S. Sharrow ,  Thomas G. Adelman ,  Frederick J. Foley

发明人： James S. Sharrow ,  Thomas G. Adelman ,  Frederick J. Foley

IPC分类号： A61M532

CPC分类号： A61M3/027 ,  A61M2210/1433

摘要： A device and method for delivering an agent to the uterine cervix make use of a seal member that defines a chamber upon engagement with the cervix. An agent delivery port in fluid communication with the chamber is provided for delivery of the agent to the uterine cervix. A vacuum port in fluid communication with the chamber allows application and retention of vacuum pressure to the chamber. At least a portion of the seal member can be made deformable in response to contact with the outer surface of the uterine cervix and application of vacuum pressure. Upon deformation, the seal member substantially seals the chamber against leakage of the agent. The seal member may include a skirt-like member that promotes adhesion of the seal member to the cervix, and enhances the effectiveness of the seal. The device facilitates vacuum application, cervical fixation, and a resulting barrier against uterine fluid leakage, providing an atraumatic, temporary cervical plug that remains effective while the vacuum is applied. In this manner, the device is capable of improving diagnostic or therapeutic effectiveness while reducing waste and expense. The device and method also can be adapted for introduction of surgical or diagnostic instruments, such as ablation catheters or endoscopes.

摘要翻译： 用于将药剂递送到子宫颈的装置和方法利用在与子宫颈接合时限定腔室的密封构件。 提供与腔室流体连通的药剂输送口用于将药剂递送到子宫颈。 与腔室流体连通的真空口允许将真空压力施加并保持到腔室。 密封构件的至少一部分可以响应于与子宫颈的外表面接触并施加真空压力而变形。 在变形时，密封构件基本上密封室以防止试剂泄漏。 密封构件可以包括促进密封构件与子宫颈粘合的裙状构件，并且提高密封的有效性。 该装置有助于真空应用，颈部固定以及抵抗子宫液体泄漏的屏障，从而提供在施加真空时保持有效的无创伤的临时子宫颈塞。 以这种方式，该装置能够提高诊断或治疗效果，同时减少浪费和费用。 该装置和方法还可适用于引入外科或诊断仪器，例如消融导管或内窥镜。